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Cited by 122Schizophrenia research and treatmentBipolar Disorder and TreatmentMental Health and Psychiatry

A typological model of schizophrenia based on age at onset, sex and familial morbidity

Sham, P.C., MacLean, C.J., Kendler, K.S.·1994·Acta Psychiatrica Scandinavica
DOI 10.1111/j.1600-0447.1994.tb01501.x
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Abstract

We investigated the age at onset distributions of schizophrenia in men and women and the relationship of age at onset and sex to the familial rates of schizophrenia and manic‐depression in data from a Swedish family study of 270 schizophrenic probands. On the logarithmic scale, the age at onset distribution of schizophrenia in both male and female relatives was bimodal, suggesting that broadly defined schizophrenia may be a mixture of 2 (probably related) disorders. The risk of schizophrenia in relatives decreased as a function of the age at onset of the proband, irrespective of the sex of the proband or relative. In contrast, the risk of manic‐depression was significantly higher in relatives of female probands with an age at onset in the twenties than in relatives of female probands with earlier or later onset, or in relatives of male probands. This suggests a third disorder related to affective psychosis, with an intermediate age at onset and female preponderance.

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Crossref · 10.1111/j.1600-0447.1994.tb01501.x

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  • Schizophrenia symptoms commonly first present in late adolescence and early adulthood, with the majority of cases occurring between ages 16 and 30 years.

    “Second, the theory must account for why the symptoms of schizophrenia so commonly first present in late adolescence and early adulthood, with the majority of cases occurring between the ages of 16 and 30 years.5”

    From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [5]

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Authors
Sham, P. C., MacLean, C. J., & Kendler, K. S.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Sham, P.C.
ORCID
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
1994-02
Volume
89
Issue
2
Pages
135-141
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/j.1600-0447.1994.tb01501.x
OpenAlex
W2139391643
Cited by
122
References
37
Citations by year
2026: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 12 · 2018: 8 · 2017: 15 · 2016: 6 · 2015: 6 · 2014: 1 · 2013: 10 · 2012: 5
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4951 d)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • John D. and Catherine T. MacArthur Foundation
  • Wellcome Trust
  • National Institute of Mental Health (R01MH041953, NIMH MH41953)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, age of onset, sex differences, familial risk, bipolar disorder, affective psychosis, bimodal age distribution, probands, family studies, schizophrenia subtypes
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bipolar Disorder, Child, Female, Humans, Male, Middle Aged, Models, Genetic, Phenotype, Risk Factors, Schizophrenia, Schizophrenic Psychology, Sex Factors, Sweden

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