The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The interleukin‐1 genotype as a severity factor in adult periodontal disease
Abstract
Abstract Although specific bacteria, dental plaque, and age are associated with periodontal disease, there are currently no reliable predictors of periodontitis severity. Studies in twins have suggested a genetic contribution to the pathogenesis of periodontitis, but previous attempts to identify genetic markers have been unsuccessful. The pro‐inflammatory cytokines interleukin‐1 (IL‐1) and tumor necrosis factor alpha (TNFα) are key regulators of the host responses to microbial infection. IL‐1 is also a major modulator of extracellular matrix catabolism and bone resorption. We report a specific genotype of the polymorphic IL‐1 gene cluster that was associated with severity of periodontitis in non‐smokers, and distinguished individuals with severe periodontitis from those with mild disease (odds ratio 18.9 for ages 40–60 years). Functionally, the specific periodontitis‐associated IL‐1 genotype comprises a variant in the IL‐1B gene that is associated with high levels of IL‐1 production. In smokers severe disease was not correlated with genotype. In this study, 86.0% of the severe periodontitis patients were accounted for by either smoking or the IL‐1 genotype. This study demonstrates that specific genetic markers, that have been associated with increased IL‐1 production, are a strong indicator of susceptibility to severe periodontitis in adults.
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Citations
Cites
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Cited by
Tonetti, M. S., Greenwell, H., & Kornman, K. S. (2018) · Journal of Periodontology · doi:10.1002/jper.18-0006 · Cited by 3,239
Self-citationSocransky, S. S., & Haffajee, A. D. (2005) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00107.x · Cited by 1,691
Tonetti, M. S., Greenwell, H., & Kornman, K. S. (2018) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12945 · Cited by 1,033
Self-citationBacterial interactions and successions during plaque development
Kolenbrander, P. E., Palmer, R. J., Rickard, A. H., Jakubovics, N. S., Chalmers, N. I., & Diaz, P. I. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00187.x · Cited by 791
Causation and pathogenesis of periodontal disease
Kinane, D. F. (2001) · Periodontology 2000 · doi:10.1034/j.1600-0757.2001.22250102.x · Cited by 553
Chapple, I. L. C., Bouchard, P., Cagetti, M. G., Campus, G., Carra, M., Cocco, F., Nibali, L., Hujoel, P., Laine, M. L., Lingström, P., et al. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12685 · Cited by 488
The Pathobiology of Periodontal Diseases May Affect Systemic Diseases: Inversion of a Paradigm
Page, R. C. (1998) · Annals of Periodontology · doi:10.1902/annals.1998.3.1.108 · Cited by 420
Long-term intracerebral inflammatory response after traumatic brain injury
Gentleman, S. M., Leclercq, P. D., Moyes, L., Graham, D. I., Smith, C., Griffin, W. S. T., & Nicoll, J. A. R. (2004) · Forensic Science International · doi:10.1016/j.forsciint.2004.06.027 · Cited by 272
Griffin, W. S. T., & Mrak, R. E. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.2.233 · Cited by 248
Smoking and inflammation: evidence for a synergistic role in chronic disease
Johannsen, A., Susin, C., & Gustafsson, A. (2014) · Periodontology 2000 · doi:10.1111/j.1600-0757.2012.00456.x · Cited by 194
Tan, K. S., Qian, L., Rosado, R., Flood, P. M., & Cooper, L. F. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.05.002 · Cited by 163
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Oral Mucosal Endotoxin Tolerance Induction in Chronic Periodontitis
Muthukuru, M., Jotwani, R., & Cutler, C. W. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.687-694.2005 · Cited by 144
Biosensor and Lab-on-a-chip Biomarker-identifying Technologies for Oral and Periodontal Diseases
Steigmann, L., Maekawa, S., Sima, C., Travan, S., Wang, C.-W., & Giannobile, W. V. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.588480 · Cited by 77
A Roadmap towards Precision Periodontics
Rakic, M., Pejcic, N., Perunovic, N., & Vojvodic, D. (2021) · Medicina · doi:10.3390/medicina57030233 · Cited by 36
Saravanakumar, P., Thallam veeravalli, P., Kumar V, A., Mohamed, K., Mani, U., Grover, M., & Thirumalai Thangarajan, S. (2017) · Cureus · doi:10.7759/cureus.1361 · Cited by 20
Effects of periodontitis on the development of asthma: The role of photodynamic therapy
Candeo, L. C., Rigonato-Oliveira, N. C., Brito, A. A., Marcos, R. L., França, C. M., Fernandes, K. P. S., Mesquita-Ferrari, R. A., Bussadori, S. K., Vieira, R. P., Lino-dos-Santos-Franco, A., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0187945 · Cited by 19
Takesh, T., Goshtasbi, A., Lin, K., Yang, S. M., Wink, C., Geisinger, M. L., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0254 · Cited by 4
Metadata
- Authors
- Kornman, K. S., Crane, A., Wang, H., Giovlne, F. S. D., Newman, M. G., Pirk, F. W., Wilson, T. G., Higginbottom, F. L., & Duff, G. W.
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 1997-01
- Volume
- 24
- Issue
- 1
- Pages
- 72-77
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W2156121631
- Cited by
- 1,187
- References
- 1
- FWCI
- 63.79
- Type
- journal article
- Language
- en
- Open access
- closed
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