Monomorphism and polymorphism at Mhc DRB loci in domestic and wild ruminants
Abstract
Summary: Genetic polymorphism at Mhc class II DRB loci was investigated in samples of musk‐ox from Canada and Greenland; moose from Sweden, Norway, Canada, and Alaska, roe deer from Norway and Sweden; reindeer from Svalbard and Norway; fallow deer from Norway and Sweden; and red deer from Norway. The results were compared with published data on cattle, bison, goal, sheep, and red deer. Cattle‐specific primers amplified a single DRB locus in all species except fallow deer and red deer, in which two loci were found. Single strand conformation polymorphism analysis and DNA sequence analysis were employed to detect genetic polymorphism. Complete monomorphism was found in musk‐ox and fallow deer. Limited polymorphism was found in the moose, roe deer, and reindeer from Svalbard, whereas intermediate to extensive DRB diversity was present in reindeer from Norway and in bison, sheep, goat, cattle, and red deer. The restricted Mhc diversity in moose, roe deer, and fallow deer is notable in relation to the dramatic population expansion of moose and roe deer in Sweden during this century and since fallow deer is used for meat and game production with good results and without any marked disease problems. The results question the view that species or populations with restricted Mhc diversity have poor resistance to infectious diseases. A phylogenelic tree analysis revealed a clustering of DRB sequences within species rather than within allelic lineages across species. The results suggest trans‐species persistence of polymorphic sequence motifs rather than of allelic lineages.
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Early work pointed to low or no genetic diversity in the muskox MHC.
“In contrast to early work pointing to low or no genetic diversity in the muskox MHC132, our tabulation of variants across multiple specimens showed a significant diversity across the MHC.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [132]
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- Authors
- Mikko, S., Røed, K., Schmutz, S., & Andersson, L.
- Affiliations
- Uppsala University (SE)
- University of Saskatchewan (CA)
- Swedish University of Agricultural Sciences (SE)
- Corresponding author
- Andersson, Leif
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 1999-02
- Volume
- 167
- Issue
- 1
- Pages
- 169-178
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2147258534
- Cited by
- 116
- References
- 56
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 4 · 2016: 4 · 2015: 5 · 2013: 7 · 2012: 7
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- MHC class II DRB, genetic polymorphism, monomorphism, ruminants, Ovibos moschatus, moose, roe deer, reindeer, fallow deer, red deer, cattle, bison, sheep, goats, phylogenetic analysis, disease resistance, population growth
- MeSH terms
- Amino Acid Sequence, Animals, Animals, Wild, HLA-DR Antigens, Humans, Major Histocompatibility Complex, Molecular Sequence Data, Polymorphism, Genetic, Ruminants, Sequence Alignment
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