The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Interleukin‐2 in the development and control of inflammatory disease
Abstract
Summary: Interleukin‐2 (IL‐2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T‐cell proliferation and T‐helper 1 (Th1) and Th2 effector T‐cell differentiation and provides T cells with a long‐lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL‐2 is important for the development, survival, and function of regulatory T cells, it enhances Fas‐mediated activation‐induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL‐2 contributes to both the induction and the termination of inflammatory immune responses.
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1 retracted
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Cited by
Cytokines in inflammatory bowel disease
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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
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Interleukin 12: still a promising candidate for tumor immunotherapy?
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Metadata
- Authors
- Hoyer, K. K., Dooms, H., Barron, L., & Abbas, A. K.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2008-10-30
- Volume
- 226
- Issue
- 1
- Pages
- 19-28
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2077238267
- Cited by
- 262
- References
- 87
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
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