The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Innate immunity to virus infection
Open accessAbstract
Summary: The innate immune system is essential for the initial detection of invading viruses and subsequent activation of adaptive immunity. Three classes of receptors, designated retinoic acid‐inducible gene I (RIG‐I)‐like receptors (RLRs), Toll‐like receptors (TLRs), and nucleotide oligomerization domain (NOD)‐like receptors (NLRs), sense viral components, such as double‐stranded RNA (dsRNA), single‐stranded RNA, and DNA. RLRs and TLRs play essential roles in the production of type I interferons (IFNs) and proinflammatory cytokines in cell type‐specific manners. While the RLRs play essential roles in the recognition of RNA viruses in various cells, plasmacytoid dendritic cells utilize TLRs for detecting virus invasion. NLRs play a role in the production of mature interleukin‐1β to dsRNA stimulation. Activation of innate immune cells is critical for mounting adaptive immune responses. In this review, we discuss recent advances in our understanding of the mechanisms of viral RNA recognition by these different types of receptors and its relation to acquired immune responses.
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Cites
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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Self-citationCardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Guo (2020) · doi:10.1186/s40779-020-00240-0 · Cited by 4,735
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759
Mitochondria in innate immune responses
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Metadata
- Authors
- Takeuchi, O., & Akira, S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2008-12-19
- Volume
- 227
- Issue
- 1
- Pages
- 75-86
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2066728093
- Cited by
- 1,229
- References
- 17
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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