Cited by 157T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation

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Yin–Yang of costimulation: crucial controls of immune tolerance and function

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Nurieva, Roza I., Liu, Xikui, Dong, Chen·2009·Immunological Reviews

DOI 10.1111/j.1600-065x.2009.00769.xPMC PMC2875245

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Abstract

Summary: In addition to signals from the T‐cell receptor complex, it has been recognized for many years that a ‘second’ signal, most notably from CD28, is also important in T‐cell activation. In the recent years, many new members of CD28 family as well as the molecules that share structural homology to CD28 ligands CD80 and CD86 have been discovered. Interestingly, some of these proteins function to dampen T‐cell activation and regulate the induction of T‐cell tolerance. Therefore, positive and negative costimulation are the two sides of the coin to fine tune T‐cell receptor signaling to determine the outcome of T‐cell receptor engagement‐tolerance versus function.

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Authors: Nurieva, R. I., Liu, X., & Dong, C.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Dong, Chen
ORCID: Nurieva, Roza I.
Liu, Xikui
Dong, Chen
Venue: Immunological Reviews
Publisher: Wiley
Published: 2009-04-21
Volume: 229
Issue: 1
Pages: 88-100
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2009.00769.x
PMC: PMC2875245
OpenAlex: W1997462426
Cited by: 157
References: 127
Citations by year: 2026: 6 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 11
FWCI: 1.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI083761)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: costimulation, T cell activation, CD28, CD80, CD86, T cell tolerance, T cell receptor signaling, immune tolerance
MeSH terms: Animals, Antibody Formation, Antigens, Differentiation, T-Lymphocyte, Humans, Immune Tolerance, Lymphocyte Activation, Receptors, Antigen, T-Cell, Receptors, Immunologic, T-Lymphocytes, Signal Transduction, Autoimmunity, Antigens, CD, CD28 Antigens, B7-1 Antigen, Apoptosis Regulatory Proteins, B7 Antigens, Inducible T-Cell Co-Stimulator Protein

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Yin–Yang of costimulation: crucial controls of immune tolerance and function

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