The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Yin–Yang of costimulation: crucial controls of immune tolerance and function
Open accessAbstract
Summary: In addition to signals from the T‐cell receptor complex, it has been recognized for many years that a ‘second’ signal, most notably from CD28, is also important in T‐cell activation. In the recent years, many new members of CD28 family as well as the molecules that share structural homology to CD28 ligands CD80 and CD86 have been discovered. Interestingly, some of these proteins function to dampen T‐cell activation and regulate the induction of T‐cell tolerance. Therefore, positive and negative costimulation are the two sides of the coin to fine tune T‐cell receptor signaling to determine the outcome of T‐cell receptor engagement‐tolerance versus function.
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“Th2 differentiation also requires co-stimulation via the interaction of CD28 on T cells with CD80 and CD86 on antigen-presenting cells (APCs).278”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [278]
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McLaughlin, J. F., Han, G., Schalper, K. A., Carvajal‐Hausdorf, D., Pelekanou, V., Rehman, J., Velcheti, V., Herbst, R. S., LoRusso, P. M., & Rimm, D. L. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.3638 · Cited by 845
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Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation
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Metadata
- Authors
- Nurieva, R. I., Liu, X., & Dong, C.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Dong, Chen
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2009-04-21
- Volume
- 229
- Issue
- 1
- Pages
- 88-100
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC2875245
- OpenAlex
- W1997462426
- Cited by
- 157
- References
- 127
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 11
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI083761)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- costimulation, T cell activation, CD28, CD80, CD86, T cell tolerance, T cell receptor signaling, immune tolerance
- MeSH terms
- Animals, Antibody Formation, Antigens, Differentiation, T-Lymphocyte, Humans, Immune Tolerance, Lymphocyte Activation, Receptors, Antigen, T-Cell, Receptors, Immunologic, T-Lymphocytes, Signal Transduction, Autoimmunity, Antigens, CD, CD28 Antigens, B7-1 Antigen, Apoptosis Regulatory Proteins, B7 Antigens, Inducible T-Cell Co-Stimulator Protein
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