Yin–Yang of costimulation: crucial controls of immune tolerance and function

Innate immune recognition

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Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

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IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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The PD‐1 pathway in tolerance and autoimmunity

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Overview of the immune response

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Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer

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PD-L1 expression in human cancers and its association with clinical outcomes

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Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation

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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

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International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

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In Situ Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas

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Induction of PD-L1 Expression by the EML4–ALK Oncoprotein and Downstream Signaling Pathways in Non–Small Cell Lung Cancer

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Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial

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Mechanisms of costimulation

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Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci

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Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

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Programmed Death Ligand 2 in Cancer-Induced Immune Suppression

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Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

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PD-1/PD-L and autoimmunity: A growing relationship

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The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease

Karin, N. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0909602 · Cited by 224

Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system

de Coaña, Y. P., Choudhury, A., & Kiessling, R. W. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.05.005 · Cited by 187

Functional cell models of the gut and their applications in food microbiology — A review

Čenčič, A., & Langerholc, T. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.03.026 · Cited by 166

Proteome Profiling of Neuroblastoma-Derived Exosomes Reveal the Expression of Proteins Potentially Involved in Tumor Progression

Marimpietri, D., Petretto, A., Raffaghello, L., Pezzolo, A., Gagliani, M. C., Tacchetti, C., Mauri, P., Melioli, G., & Pistoia, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075054 · Cited by 159

Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein

Janakiram, M., Chinai, J. M., Fineberg, S., Fiser, A., Montagna, C., Medavarapu, R., Castano, E., Jeon, H., Ohaegbulam, K. C., Zhao, R., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1495 · Cited by 153

Monocyte programmed death ligand-1 expression after 3–4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study

Shao, R., Fang, Y., Han, Y., Zhao, L., Jiang, Z., & Li, C. (2016) · Critical Care · doi:10.1186/s13054-016-1301-x · Cited by 152

Antigen presentation in EAE: role of microglia, macrophages and dendritic cells

Almolda, B. (2010) · Frontiers in bioscience · doi:10.2741/3781 · Cited by 141

BIN1 reverses PD-L1-mediated immune escape by inactivating the c-MYC and EGFR/MAPK signaling pathways in non-small cell lung cancer

Wang, J., Jia, Y., Zhao, S., Zhang, X., Wang, X., Han, X., Wang, Y., Ma, M., Shi, J., & Liu, L. (2017) · Oncogene · doi:10.1038/onc.2017.217 · Cited by 118

Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma

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CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+ T Cells

Leitner, J., Herndler-Brandstetter, D., Zlabinger, G. J., Grubeck-Loebenstein, B., & Steinberger, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401917 · Cited by 104

IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer

Gao, W., Wen, H., Liang, L., Dong, X., Du, R., Zhou, W., Zhang, X., Zhang, C., Xiang, R., & Li, N. (2021) · Theranostics · doi:10.7150/thno.45280 · Cited by 93

ICOS Mediates the Generation and Function of CD4+CD25+Foxp3+ Regulatory T Cells Conveying Respiratory Tolerance

Busse, M., Krech, M., Meyer‐Bahlburg, A., Hennig, C., & Hansen, G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103581 · Cited by 89

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis

Ho, P. P.-K., & Steinman, L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524890113 · Cited by 85

Heterogeneity of PD-L1 Expression and Relationship with Biology of NSCLC

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T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells

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Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4 + T cells

Wakamatsu, E., Mathis, D. J., & Benoist, C. O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220688110 · Cited by 80

Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus

Sullivan, B. A., Tsuji, W. H., Kivitz, A., Peng, J. Z., Arnold, G. E., Boedigheimer, M. J., Chiu, K., Green, C. L., Kaliyaperumal, A., Wang, C., et al. (2016) · Lupus Science & Medicine · doi:10.1136/lupus-2016-000146 · Cited by 76

Characterization of Programmed Death-1 Homologue-1 (PD-1H) Expression and Function in Normal and HIV Infected Individuals

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Systemic lupus erythematosus: pathogenesis and targeted therapy

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Pathogenesis, Clinical Manifestations and Management of Immune Checkpoint Inhibitors Toxicity

Inno, A., Metro, G., Bironzo, P., Grimaldi, A. M., Grego, E., Nunno, V. D., Picasso, V., Massari, F., & Gori, S. (2017) · Tumori Journal · doi:10.5301/tj.5000625 · Cited by 70

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance

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Oncolytic Virus-Mediated Reversal of Impaired Tumor Antigen Presentation

Gujar, S. A., & Lee, P. W. K. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00077 · Cited by 71

Receptors and ligands implicated in human T cell costimulatory processes

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Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation

Celada, L. J., Rotsinger, J. E., Young, A., Shaginurova, G. I., Shelton, D. A., Hawkins, C., & Drake, W. P. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0037oc · Cited by 57

Substance P Is a Key Mediator of Stress-Induced Protection from Allergic Sensitization via Modified Antigen Presentation

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Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE

Almolda, B., González, B., & Castellano, B. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.021 · Cited by 53

Functional Divergence among CD103+Dendritic Cell Subpopulations following Pulmonary Poxvirus Infection

Beauchamp, N. M., Busick, R. Y., & Alexander‐Miller, M. A. (2010) · Journal of Virology · doi:10.1128/jvi.00892-10 · Cited by 50

The CD28 Transmembrane Domain Contains an Essential Dimerization Motif

Leddon, S. A., Fettis, M. M., Abramo, K., Kelly, R., Oleksyn, D. W., & Miller, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01519 · Cited by 49

Extracellular Hemoglobin Polarizes the Macrophage Proteome toward Hb-Clearance, Enhanced Antioxidant Capacity and Suppressed HLA Class 2 Expression

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Immunoregulatory molecules are master regulators of inflammation during the immune response

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CTLA4Ig Inhibits Effector T Cells through Regulatory T Cells and TGF-β

Deppong, C. M., Bricker, T. L., Rannals, B. D., van Rooijen, N., Hsieh, C., & Green, J. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300830 · Cited by 42

Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models

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A Randomized Controlled Trial to Evaluate Inhibition of T-Cell Costimulation in Allergen-induced Airway Inflammation

Parulekar, A. D., Boomer, J. S., Patterson, B., Yin‐Declue, H., Deppong, C. M., Wilson, B. S., Jarjour, N. N., Castro, M., & Green, J. M. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1205oc · Cited by 42

Similarities between the Yin/Yang Doctrine and Hormesis in Toxicology and Pharmacology

Sun, H., Calabrese, E. J., Lin, Z., Lian, B., & Zhang, X. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.05.004 · Cited by 40

Modifying CAR-T cells with anti-checkpoints in cancer immunotherapy: A focus on anti PD-1/PD-L1 antibodies

Najafi, S., & Mortezaee, K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122387 · Cited by 39

ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo

Gigliotti, C. L., Boggio, E. M., Clemente, N., Shivakumar, Y., Toth, E., Sblattero, D., D’Amelio, P., Isaia, G. C., Dianzani, C., Yagi, J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600424 · Cited by 41

Targeting lymphocyte co-stimulation: From bench to bedside

Felix, N. J., Suri, A., Salter–Cid, L., Nadler, S. G., Gujrathi, S., Corbo, M., & Aranda, R. (2010) · Autoimmunity · doi:10.3109/08916931003674741 · Cited by 36

Introduction to Costimulation and Costimulatory Molecules

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Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma

Gao, L., Xia, L., Ji, W., Zhang, Y., Xia, W., & Lü, S. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101148 · Cited by 37

Are Microglial Cells the Regulators of Lymphocyte Responses in the CNS?

Almolda, B., González, B., & Castellano, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00440 · Cited by 34

CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk

Mayer, E., Hölzl, M. A., Ahmadi, S. M., Dillinger, B., Pilat, N., Fuchs, D., Wekerle, T., & Heitger, A. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.02.007 · Cited by 34

Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex

Garrett-Thomson, S. C., Massimi, A. B., Fedorov, E. V., Bonanno, J. B., Scandiuzzi, L., Hillerich, B., Seidel, R. D., Love, J. D., Garforth, S., Guha, C., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233578 · Cited by 30

Agonistic Antibody to CD40 Boosts the Antitumor Activity of Adoptively Transferred T Cells In Vivo

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Regulatory properties of statins and rho gtpases prenylation inhibitiors to stimulate melanoma immunogenicity and promote anti‐melanoma immune response

Sarrabayrouse, G., Pich-Bavastro, C., Teiti, I., & Tilkin‐Mariame, A. F. (2016) · International Journal of Cancer · doi:10.1002/ijc.30422 · Cited by 33

T-cell activation and transplantation tolerance

Priyadharshini, B., Greiner, D. L., & Brehm, M. A. (2011) · Transplantation Reviews · doi:10.1016/j.trre.2011.09.002 · Cited by 30

A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection, with Adaptive Evolution of Disease Alleles

Forni, D., Cagliani, R., Pozzoli, U., Colleoni, M., Riva, S., Biasin, M., Filippi, G., GIOIA, L. D., Gnudi, F., Comi, G. P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.008 · Cited by 29

Cell Surface Markers in HTLV-1 Pathogenesis

Thoma‐Kress, A. K., Grassmann, R., & Fleckenstein, B. (2011) · Viruses · doi:10.3390/v3081439 · Cited by 29

Unchecked immunity: a unique case of sequential immune-related adverse events with Pembrolizumab

Shah, N., Jacob, J. M., Househ, Z., Shiner, E. K., Baird, L., & Soudy, H. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0727-5 · Cited by 29

A splicing isoform of PD-1 promotes tumor progression as a potential immune checkpoint

Wang, X., Liu, T., Li, Y., Ding, A., Zhang, C., Gu, Y., Zhao, X., Cheng, S., Cheng, T., Wu, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53561-2 · Cited by 27

Live cell superresolution-structured illumination microscopy imaging analysis of the intercellular transport of microvesicles and costimulatory proteins via nanotubes between immune cells

Halász, H., Ghadaksaz, A., Madarász, T., Huber, K., Harami, G. M., Tóth, E. A., Osteikoetxea-Molnár, A., Kovács, M., Balogi, Z., Nyitrai, M., et al. (2018) · Methods and Applications in Fluorescence · doi:10.1088/2050-6120/aad57d · Cited by 27

The Outer Membrane Vesicles of Aeromonas hydrophila ATCC® 7966TM: A Proteomic Analysis and Effect on Host Cells

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Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis

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Immune checkpoint inhibitors in esophageal cancer: Clinical development and perspectives

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A Potential New Pathway for PD-L1 Costimulation of the CD8-T Cell Response to Listeria monocytogenes Infection

Xu, D., Fu, H.-H., Obar, J., Park, J.-J., Tamada, K., Yagita, H., & Lefrançois, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056539 · Cited by 28

Autoimmune Therapies Targeting Costimulation and Emerging Trends in Multivalent Therapeutics

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Critical co-stimulatory pathways in the stability of Foxp3+ Treg cell homeostasis in Type I Diabetes

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The Role of Immune Checkpoint Receptors in Regulating Immune Reactivity in Lupus

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Prognostic Implications of Immune Infiltrates in the Breast Cancer Microenvironment: The Role of Expressions of CTLA-4, PD-1, and LAG-3

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