Yin–Yang of costimulation: crucial controls of immune tolerance and function

Innate immune recognition

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Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

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IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

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Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

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Cancer regression and autoimmunity induced by cytotoxic t lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

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T cell anergy

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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

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Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

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Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

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Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

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Tissue expression of PD-L1 mediates peripheral T cell tolerance

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

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TH17 cells in development: an updated view of their molecular identity and genetic programming

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Human IL-17: a novel cytokine derived from T cells

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B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

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Expression of Programmed Death 1 Ligands by Murine T Cells and APC

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ICOS co-stimulatory receptor is essential for T-cell activation and function

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B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

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PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

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The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

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PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

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Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

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T-cell co-stimulation through B7RP-1 and ICOS

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A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

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B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

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B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

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Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

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ICOS is essential for effective T-helper-cell responses

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Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

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Follicular B helper T cells in antibody responses and autoimmunity

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ICOS is critical for CD40-mediated antibody class switching

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PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

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The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

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The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

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Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

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B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

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Sarcoidosis is associated with a truncating splice site mutation in BTNL2

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CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

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B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

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Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

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Establishment of NOD- Pdcd1 -/- mice as an efficient animal model of type I diabetes

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Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

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B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation

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Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

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IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis

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B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

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ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells

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The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

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The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo

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Costimulatory regulation of T cell function

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Murine B7-H3 is a negative regulator of T cells

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B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival

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c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

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Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

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Characterization of Mouse and Human B7-H3 Genes

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Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

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Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells

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Untitled work

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Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

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Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

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Molecular Characterization of Human 4Ig-B7-H3, a Member of the B7 Family with Four Ig-Like Domains

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Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

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T‐cell tolerance or function is determined by combinatorial costimulatory signals

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Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family

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Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses

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