The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Oxidative stress in multiple sclerosis: Central and peripheral mode of action
Open accessAbstract
Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal models. One of the most studied cell populations in the context of ROS-mediated tissue damage in MS are macrophages and their CNS companion, microglia cells. However, and this aspect is less well appreciated, the extracellular and intracellular redox milieu is integral to many processes underlying T cell activation, proliferation and apoptosis. In this review article we discuss how oxidative stress affects central as well as peripheral aspects of MS and how manipulation of ROS pathways can potentially affect the course of the disease. It is our strong belief that the well-directed shaping of ROS pathways has the potential to ameliorate disease progression in MS.
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1 retracted
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Myeloid-derived-suppressor cells as regulators of the immune system
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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
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Cited by
Redox Signaling by Reactive Electrophiles and Oxidants
Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00698 · Cited by 359
Kruk, J., Aboul-Enein, H. Y., Kładna, A., & Bowser, J. E. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1612059 · Cited by 284
The Cuprizone Model: Dos and Do Nots
Zhan, J., Mann, T., Joost, S., Behrangi, N., Frank, M., & Kipp, M. (2020) · Cells · doi:10.3390/cells9040843 · Cited by 171
Self-citationJafarzadeh, A., & Nemati, M. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.09.003 · Cited by 84
Microglial NLRP3 inflammasome activation in multiple sclerosis
(2020) · Advances in Protein Chemistry and Structural Biology · doi:10.1016/bs.apcsb.2019.08.007 · Cited by 83
Metadata
- Authors
- Ohl, K., Tenbrock, K., & Kipp, M.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 277
- Pages
- 58-67
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2180696344
- Cited by
- 317
- References
- 122
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Ohl, K., Tenbrock, K., & Kipp, M. (2016). Oxidative stress in multiple sclerosis: Central and peripheral mode of action. Experimental Neurology. https://doi.org/10.1016/j.expneurol.2015.11.010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
