The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity
Open accessAbstract
Summary: Host cells trigger signals for innate immune responses upon recognition of conserved structures in microbial pathogens. Nucleic acids, which are critical components for inheriting genetic information in all species including pathogens, are key structures sensed by the innate immune system. The corresponding receptors for foreign nucleic acids include members of Toll‐like receptors, RIG‐I‐like receptors, and intracellular DNA sensors. While nucleic acid recognition by these receptors is required for host defense against the pathogen, there is a potential risk to the host of self‐nucleic acids recognition, thus precipitating autoimmune and autoinflammatory diseases. In this review, we discuss the roles of nucleic acid‐sensing receptors in guarding against pathogen invasion, discriminating between self and non‐self, and contributing to autoimmunity and autoinflammatory diseases.
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Cites
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BackgroundAIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Cited by
Origins, structures, and functions of circulating DNA in oncology
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Metadata
- Authors
- Kawasaki, T., Kawai, T., & Akira, S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2011-08-26
- Volume
- 243
- Issue
- 1
- Pages
- 61-73
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1845637086
- Cited by
- 217
- References
- 22
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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