Cited by 110NF-κB Signaling PathwaysImmune Response and InflammationCytokine Signaling Pathways and Interactions

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Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

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Hildebrand, Joanne M., Yi, Zuoan, Buchta, Claire M., Poovassery, Jayakumar, Stunz, Laura L., Bishop, Gail A.·2011·Immunological Reviews

DOI 10.1111/j.1600-065x.2011.01055.xPMC PMC3202299

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Abstract

Summary: A large and diverse group of receptors utilizes the family of cytoplasmic signaling proteins known as tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs). In recent years, there has been a resurgence of interest and exploration of the roles played by TRAF3 and TRAF5 in cellular regulation, particularly in cells of the immune system, the cell types of focus in this review. This work has revealed that TRAF3 and TRAF5 can play diverse roles for different receptors even in the same cell type, as well as distinct roles in different cell types. Evidence indicates that TRAF3 and TRAF5 play important roles beyond the TNFR‐superfamily (SF) and viral mimics of its members, mediating certain innate immune receptor and cytokine receptor signals, and most recently, signals delivered by the T‐cell receptor (TCR) signaling complex. Additionally, much research has demonstrated the importance of TRAF3‐mediated cellular regulation via its cytoplasmic interactions with additional signaling proteins. In particular, we discuss below evidence for the participation by TRAF3 in a number of the regulatory post‐translational modifications involving ubiquitin that are important in various signaling pathways.

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Authors: Hildebrand, J. M., Yi, Z., Buchta, C. M., Poovassery, J., Stunz, L. L., & Bishop, G. A.
Affiliations: University of Iowa (US)
Corresponding author: Bishop, Gail A.
ORCID: Hildebrand, Joanne M.
Yi, Zuoan
Bishop, Gail A.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2011-10-21
Volume: 244
Issue: 1
Pages: 55-74
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2011.01055.x
PMC: PMC3202299
OpenAlex: W1583006772
Cited by: 110
References: 187
Citations by year: 2026: 3 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 4
FWCI: 0.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (CA 099997, R01CA099997)
National Institute of Allergy and Infectious Diseases (AI 49993, R01AI049993, R56AI049993, R56AI028847, R01AI028847, AI28847, T32AI007485)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: TRAF3, TRAF5, TRAF, immune cell signaling, TNF receptor superfamily, innate immune receptors, cytokine receptor signaling, T cell receptor signaling, ubiquitination, post-translational modification
MeSH terms: Animals, B-Lymphocytes, Cell Survival, Humans, Immunity, Innate, Protein Binding, Protein Processing, Post-Translational, T-Lymphocytes, Tumor Necrosis Factor-alpha, Signal Transduction, Gene Expression, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice, Knockout, Myeloid Cells, Ubiquitin, TNF Receptor-Associated Factor 3, TNF Receptor-Associated Factor 5, Mice

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Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

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