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Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions
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Summary: A large and diverse group of receptors utilizes the family of cytoplasmic signaling proteins known as tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs). In recent years, there has been a resurgence of interest and exploration of the roles played by TRAF3 and TRAF5 in cellular regulation, particularly in cells of the immune system, the cell types of focus in this review. This work has revealed that TRAF3 and TRAF5 can play diverse roles for different receptors even in the same cell type, as well as distinct roles in different cell types. Evidence indicates that TRAF3 and TRAF5 play important roles beyond the TNFR‐superfamily (SF) and viral mimics of its members, mediating certain innate immune receptor and cytokine receptor signals, and most recently, signals delivered by the T‐cell receptor (TCR) signaling complex. Additionally, much research has demonstrated the importance of TRAF3‐mediated cellular regulation via its cytoplasmic interactions with additional signaling proteins. In particular, we discuss below evidence for the participation by TRAF3 in a number of the regulatory post‐translational modifications involving ubiquitin that are important in various signaling pathways.
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“TRAF3 (FC = −1.12, p = 0.03) is a TNF-receptor-associated factor which is critical for NF-kappaB activation and cell death pathways [60].”
From Early onset senescence and cognitive impairment in a murine model of repeated mTBI (2021) · cites this paper as [60]
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Differential B‐lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1
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Self-citationRegulation of TRAF2 Signaling by Self-induced Degradation
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Self-citationSynergistic B Cell Activation by CD40 and the B Cell Antigen Receptor
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Differential Regulation of CD40-Mediated TNF Receptor-Associated Factor Degradation in B Lymphocytes
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Self-citationT3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK1
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Antigen Receptor Signals Rescue B Cells from TLR Tolerance
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Multiple roles of TRAF3 signaling in lymphocyte function
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Self-citationTNAP, a Novel Repressor of NF-κB-inducing Kinase, Suppresses NF-κB Activation
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A novel polymorphism of the human CD40 receptor with enhanced function
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Self-citationTRAF3 Interacts with Smac/DIABLO and Enhances the Proapoptotic Effect of Smac/DIABLO in Cytoplasm
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Metadata
- Authors
- Hildebrand, J. M., Yi, Z., Buchta, C. M., Poovassery, J., Stunz, L. L., & Bishop, G. A.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Bishop, Gail A.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2011-10-21
- Volume
- 244
- Issue
- 1
- Pages
- 55-74
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC3202299
- OpenAlex
- W1583006772
- Cited by
- 110
- References
- 187
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 4
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 099997, R01CA099997)
- National Institute of Allergy and Infectious Diseases (AI 49993, R01AI049993, R56AI049993, R56AI028847, R01AI028847, AI28847, T32AI007485)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- TRAF3, TRAF5, TRAF, immune cell signaling, TNF receptor superfamily, innate immune receptors, cytokine receptor signaling, T cell receptor signaling, ubiquitination, post-translational modification
- MeSH terms
- Animals, B-Lymphocytes, Cell Survival, Humans, Immunity, Innate, Protein Binding, Protein Processing, Post-Translational, T-Lymphocytes, Tumor Necrosis Factor-alpha, Signal Transduction, Gene Expression, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice, Knockout, Myeloid Cells, Ubiquitin, TNF Receptor-Associated Factor 3, TNF Receptor-Associated Factor 5, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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