The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Regulation of NF‐κB by deubiquitinases
Open accessAbstract
Summary: The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB signaling pathways by functioning as a scaffold to recruit kinase complexes containing ubiquitin‐binding domains. Ubiquitination is balanced by deubiquitinases that cleave polyubiquitin chains and oppose the function of E3 ubiquitin ligases. Deubiquitinases therefore play an important role in the termination of NF‐κB signaling and the resolution of inflammation. In this review, we focus on NF‐κB regulation by deubiquitinases with an emphasis on A20 and CYLD. Deubiquitinases and the ubiquitin/proteasome components that regulate NF‐κB may serve as novel therapeutic targets for inflammatory diseases and cancer.
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Cites
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Cited by
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
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NF-κB in inflammation and renal diseases
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The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity
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Regulation of NF‐κB by ubiquitination and degradation of the IκBs
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Metadata
- Authors
- Harhaj, E. W., & Dixit, V. M.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2012-03
- Volume
- 246
- Issue
- 1
- Pages
- 107-124
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1949280308
- Cited by
- 260
- References
- 22
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- green
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