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Cited by 30Circadian rhythm and melatoninEstrogen and related hormone effectsHypothalamic control of reproductive hormones

Changes in nocturnal pineal melatonin synthesis during the perimenopausal period: Relation to estrogen levels in female rats

Okatani, Yuji, Morioka, Nobuyuki, Hayashi, Kazutoshi·1999·Journal of Pineal Research
DOI 10.1111/j.1600-079x.1999.tb00598.x
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Abstract

Abstract: To evaluate changes in melatonin synthesis during the perimenopausal period in the female rat and to determine the effects of estrogen on melatonin synthesis, pineal levels of tryptophan, melatonin and norepinephrine and activities of N‐acetyltransferase (NAT) and hydroxyindole‐O‐methyltransferase (HIOMT) were determined. Homogenates for assay were prepared from the pineal glands of female virgin Sprague‐Dawley rats between 4 and 24 months of age in the middle of the dark period of a daily light/dark cycle. Serum 17 β‐estradiol (E 2) concentrations were also determined. Pineal melatonin levels significantly decreased from month 4–12 and significantly increased from month 12–16, decreasing thereafter. Serum E 2 concentrations significantly decreased from month 12–16, and remained low thereafter. No significant changes in tryptophan or norepinephrine were seen. NAT activities paralleled the time course of changes in melatonin. HIOMT activities decreased gradually from month 4–24. Subcutaneous implantation of an E 2 capsule between months 12 and 16 resulted in significant decreases in levels of melatonin and NAT activity at month 16. Ovariectomy at month 4 or 12 led to significant increases in the levels of melatonin and NAT activity. These findings represent a temporal increase in pineal melatonin synthesis during the perimenopausal period, and suggest that the increase in melatonin synthesis activity at that time might result from decreasing levels of endogenous estrogen. The effect of estrogen on melatonin synthesis appeared to involve modulation of NAT activy.

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Crossref · 10.1111/j.1600-079x.1999.tb00598.x

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  • A low-estrogen environment is associated with increased melatonin levels in menopausal women, which is suppressed after exogenous estrogen administration, and oophorectomy in premenopausal women results in a significant increase in melatonin secretion.

    “For example, a low-estrogen environment was associated with increased melatonin levels in menopausal women, which was suppressed after exogenous estrogen administration, and oopherectomy in premenopausal women results in a significant increase in melatonin secretion [87].”

    From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [87]

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Authors
Okatani, Y., Morioka, N., & Hayashi, K.
Affiliations
Kōchi University (JP)
Corresponding author
Okatani, Yuji
ORCID
Hayashi, Kazutoshi
Venue
Journal of Pineal Research
Publisher
Wiley
Published
1999-09
Volume
27
Issue
2
Pages
65-72
ISSN
  • 0742-3098 (ISSN-L)
  • 1600-079X
DOI
10.1111/j.1600-079x.1999.tb00598.x
OpenAlex
W1970625685
Cited by
30
References
41
Citations by year
2025: 1 · 2024: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2015: 2 · 2014: 2 · 2013: 1
FWCI
0.25
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2708 d)
Locations
  • Journal of Pineal Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
pineal gland, melatonin synthesis, perimenopause, estrogen, estradiol, N-acetyltransferase, hydroxyindole-O-methyltransferase, tryptophan, norepinephrine, ovariectomy, female rats, menopause
MeSH terms
Acetylserotonin O-Methyltransferase, Aging, Animals, Arylamine N-Acetyltransferase, Circadian Rhythm, Darkness, Estradiol, Female, Melatonin, Norepinephrine, Pineal Gland, Tryptophan, Rats, Sprague-Dawley, Rats

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