The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes
Abstract
Abstract: Melatonin, the main secretory product of the pineal gland, is known to collaborate against oxidative stress within cells, but its mechanism of action in terms of stimulating antioxidant enzymes remains unclear. Herein, we propose that melatonin modulates antioxidant enzyme activities via its interaction with calmodulin, which in turn inhibits downstream processes that lead to the inactivation of nuclear ROR α melatonin receptor. Eventually, this nuclear transcription factor downregulates NF‐κ B‐induced antioxidant enzyme expression. Therefore, the increment in antioxidant enzyme activities induced by melatonin involves the inhibition of the ROR α pathway. Thus, in addition to its direct free radical scavenging activities, melatonin has important actions in oxidative defense by stimulating enzymes which metabolize free radicals and radical products to innocuous metabolites.
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Cites
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Regulation of antioxidant enzymes: a significant role for melatonin
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Melatonin : a potent, endogenous hydroxyl radical scavenger
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Cited by
Melatonin—A pleiotropic, orchestrating regulator molecule
Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843
Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology
Reiter, R. J., Tan, D. X., Korkmaz, A., & Rosales-Corral, S. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt054 · Cited by 371
Cardiovascular diseases: protective effects of melatonin
Tengattini, S., Reiter, R. J., Tan, D., Terron, M. P., Rodella, L. F., & Rezzani, R. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00518.x · Cited by 337
Impact of oxidative stress on female fertility
Ruder, E. H., Hartman, T. J., & Goldman, M. B. (2009) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32832924ba · Cited by 255
Vriend, J., & Reiter, R. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.013 · Cited by 246
Metadata
- Authors
- Tomás‐Zapico, C., & Coto‐Montes, A.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2005-06-15
- Volume
- 39
- Issue
- 2
- Pages
- 99-104
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W1936195323
- Cited by
- 503
- References
- 69
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
