The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin‐receptor status
Abstract
Abstract: There are functional inter‐relationships between the beta cells of the endocrine pancreas and the pineal gland, where the synchronizing circadian molecule melatonin originates. The aim of this study was to elucidate a putative interaction between insulin and melatonin in diabetic patients and a diabetic rat model. We analyzed glucose, insulin, and melatonin levels of type 2 patients, as well as type 2 diabetic Goto Kakizaki (GK) rats by radioimmunoassay. Expression of pancreatic melatonin and pineal insulin receptors, as well as arylalkylamine‐N‐acetyltransferase (AANAT), was determined by real‐time reverse transcriptase polymerase chain reaction (RT‐PCR). The AANAT enzyme activity was measured in pineal homogenates. Diabetic patients showed a decrease in melatonin levels, while in the pancreas of GK rats an upregulation of the melatonin‐receptor mRNA was determined. The pancreatic islets of GK rats showed expression of the mRNA for the pancreatic melatonin (MT1) receptor, which had previously been identified in rats and insulinoma (INS1) cells. Besides their presence in animal cells, the MT1‐receptor transcript was also detected in human pancreas by RT‐PCR. Whereas the rat pancreatic mRNA expression of the MT1‐receptor was significantly increased, the activity of the pineal AANAT enzyme was reduced. The latter observation was in accordance with plasma melatonin levels. The insulin‐receptor mRNA of the pineal gland was found to be reduced in GK rats. Our observations suggest a functional inter‐relationship between melatonin and insulin, and may indicate a reduction of melatonin in the genesis of diabetes.
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Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets
Peschke, E., & Peschke, D. (1998) · Diabetologia · doi:10.1007/s001250051034 · Cited by 150
Self-citationCagnacci, A., Arangino, S., Renzi, A., Paoletti, A. M., Melis, G. B., Cagnacci, P., & Volpe, A. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01232.x · Cited by 139
Kemp, D. M., Ubeda, M., & Habener, J. F. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00064-3 · Cited by 122
Cited by
Melatonin—A pleiotropic, orchestrating regulator molecule
Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611
Melatonin secretion and the incidence of type 2 diabetes
McMullan, C. J., Schernhammer, E. S., Rimm, E. B., Hu, F. B., & Forman, J. P. (2013) · JAMA · doi:10.1001/jama.2013.2710 · Cited by 369
Circadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 365
Melatonin, endocrine pancreas and diabetes
Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00519.x · Cited by 309
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Metadata
- Authors
- Peschke, E., Frese, T., Chankiewitz, E., Peschke, D., Preiss, U., Schneyer, U., Spessert, R., & Mühlbauer, E.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2005-11-09
- Volume
- 40
- Issue
- 2
- Pages
- 135-143
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2107832950
- Cited by
- 197
- References
- 4
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peschke, E., Frese, T., Chankiewitz, E., Peschke, D., Preiss, U., Schneyer, U., Spessert, R., & Mühlbauer, E. (2006). Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin‐receptor status. Journal of Pineal Research. https://doi.org/10.1111/j.1600-079x.2005.00287.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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