Melatonin secretion and the incidence of type 2 diabetes

McMullan, Ciaran J.; Schernhammer, Eva S.; Rimm, Eric B.; Hu, Frank B.; Forman, John P.

doi:10.1001/jama.2013.2710

Cited by 369Circadian rhythm and melatoninSleep and related disordersAdipokines, Inflammation, and Metabolic Diseases

Melatonin secretion and the incidence of type 2 diabetes

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McMullan, Ciaran J., Schernhammer, Eva S., Rimm, Eric B., Hu, Frank B., Forman, John P.·2013·JAMA

DOI 10.1001/jama.2013.2710PMC PMC3804914

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Abstract

IMPORTANCE: Loss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes. Additionally, in a cross-sectional analysis of persons without diabetes, lower nocturnal melatonin secretion was associated with increased insulin resistance. OBJECTIVE: To study the association between melatonin secretion and the risk of developing type 2 diabetes. DESIGN, SETTING, AND PARTICIPANTS: Case-control study nested within the Nurses' Health Study cohort. Among participants without diabetes who provided urine and blood samples at baseline in 2000, we identified 370 women who developed type 2 diabetes from 2000-2012 and matched 370 controls using risk-set sampling. MAIN OUTCOME MEASURES: Associations between melatonin secretion at baseline and incidence of type 2 diabetes were evaluated with multivariable conditional logistic regression controlling for demographic characteristics, lifestyle habits, measures of sleep quality, and biomarkers of inflammation and endothelial dysfunction. RESULTS: The median urinary ratios of 6-sulfatoxymelatonin to creatinine were 28.2 ng/mg (5%-95% range, 5.5-84.2 ng/mg) among cases and 36.3 ng/mg (5%-95% range, 6.9-110.8 ng/mg) among controls. Women with lower ratios of 6-sulfatoxymelatonin to creatinine had increased risk of diabetes (multivariable odds ratio, 1.48 [95% CI, 1.11-1.98] per unit decrease in the estimated log ratio of 6-sulfatoxymelatonin to creatinine). Compared with women in the highest ratio category of 6-sulfatoxymelatonin to creatinine, those in the lowest category had a multivariable odds ratio of 2.17 (95% CI, 1.18-3.98) of developing type 2 diabetes. Women in the highest category of melatonin secretion had an estimated diabetes incidence rate of 4.27 cases/1000 person-years compared with 9.27 cases/1000 person-years in the lowest category. CONCLUSIONS AND RELEVANCE: Lower melatonin secretion was independently associated with a higher risk of developing type 2 diabetes. Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diabetes within the general population.

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Some studies show that elevated melatonin concentrations are associated with improved glucose control.
“While some studies show that elevated melatonin concentrations are associated with improved glucose control (15)(16)(17)”
From Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [16]

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Diagnosis and classification of diabetes mellitus
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974 · see citing works
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DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works
Television Watching and Other Sedentary Behaviors in Relation to Risk of Obesity and Type 2 Diabetes Mellitus in Women
Hu, F. B., Li, T. Y., Colditz, G. A., Willett, W. C., & Manson, J. E. (2003) · JAMA · doi:10.1001/jama.289.14.1785 · Cited by 1,892 · see citing works
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American Diabetes Association (2011) · Diabetes Care · doi:10.2337/dc12-s064 · Cited by 1,494 · see citing works
Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire
Hu, F. B., Rimm, E., Smith-Warner, S. A., Feskanich, D., Stampfer, M. J., Ascherio, A., Sampson, L., & Willett, W. C. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.2.243 · Cited by 1,165 · see citing works
Physical activity and incidence of non-insulin-dependent diabetes mellitus in women
Manson, J. E., Stampfer, M. J., Colditz, G. A., Willett, W. C., Rosner, B., Hennekens, C. H., Speizer, F. E., Rimm, E. B., & Krolewski, A. S. (1991) · The Lancet · doi:10.1016/0140-6736(91)90664-b · Cited by 1,164 · see citing works
The basic physiology and pathophysiology of melatonin
Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951 · see citing works
Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932 · see citing works
A prospective study of self-reported sleep duration and incident diabetes in women
Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., Patel, S., & Hu, F. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.380 · Cited by 883 · see citing works
A Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart Disease
Stampfer, M. J., Willett, W. C., Colditz, G. A., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510243131703 · Cited by 855 · see citing works
Sleep duration as a risk factor for the development of type 2 diabetes
Yaggi, H. K., Araujo, A. B., & McKinlay, J. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-0879 · Cited by 790 · see citing works
Diagnosing Insulin Resistance in the General Population
McAuley, K. A., Williams, S., Mann, J. I., Walker, R. J., Lewis‐Barned, N., Temple, L. A., & Duncan, A. W. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.460 · Cited by 752 · see citing works
Variants in MTNR1B influence fasting glucose levels
Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Þorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A., Aulchenko, Y. S., et al. (2008) · Nature Genetics · doi:10.1038/ng.290 · Cited by 743 · see citing works
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611 · see citing works
Ethnicity, Obesity, and Risk of Type 2 Diabetes in Women
Shai, I., Jiang, R., Manson, J. E., Stampfer, M. J., Willett, W. C., Colditz, G. A., & Hu, F. B. (2006) · Diabetes Care · doi:10.2337/dc06-0057 · Cited by 479 · see citing works
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Soranzo, N., Sanna, S., Wheeler, E., Gieger, C., Radke, D., Dupuis, J., Bouatia‐Naji, N., Langenberg, C., Prokopenko, I., Stolerman, E., et al. (2010) · Diabetes · doi:10.2337/db10-0502 · Cited by 445 · see citing works
Trends in the Incidence of Type 2 Diabetes Mellitus From the 1970s to the 1990s
Fox, C. S., Pencina, M. J., Meigs, J. B., Vasan, R. S., Levitzky, Y. S., & D’Agostino, R. B. (2006) · Circulation · doi:10.1161/circulationaha.106.613828 · Cited by 378 · see citing works
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
The Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC), Bonnefond, A., Clément, N., Fawcett, K., Yengo, L., Vaillant, E., Guillaume, J.-L., Dechaume, A., Payne, F., Roussel, R., et al. (2012) · Nature Genetics · doi:10.1038/ng.1053 · Cited by 363 · see citing works
Snoring as a Risk Factor for Type II Diabetes Mellitus: A Prospective Study
Al‐Delaimy, W. K., Manson, J. E., Willett, W. C., Stampfer, M. J., & Hu, F. B. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.5.387 · Cited by 328 · see citing works
Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity
Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281 · see citing works
A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
Kwak, S. H., Kim, S., Cho, Y. M., Go, M. J., Cho, Y. S., Choi, S. H., Moon, M. K., Jung, H. S., Shin, H. D., Kang, H. M., et al. (2012) · Diabetes · doi:10.2337/db11-1034 · Cited by 273 · see citing works
What Does the Odds Ratio Estimate in a Case-Control Study?
PEARCE, N. (1993) · International Journal of Epidemiology · doi:10.1093/ije/22.6.1189 · Cited by 266 · see citing works
Diet-Quality Scores and the Risk of Type 2 Diabetes in Men
de Koning, L., Chiuve, S. E., Fung, T. T., Willett, W. C., Rimm, E. B., & Hu, F. B. (2011) · Diabetes Care · doi:10.2337/dc10-2352 · Cited by 252 · see citing works
Carbohydrate Intake, Glycemic Index, Glycemic Load, and Dietary Fiber in Relation to Risk of Stroke in Women
Oh, K. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi026 · Cited by 220 · see citing works
Epidemiology of Urinary Melatonin in Women and Its Relation to Other Hormones and Night Work
Schernhammer, E. S., ROSNER, B. A., Willett, W. C., Laden, F., Colditz, G. A., & Hankinson, S. E. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.936.13.6 · Cited by 214 · see citing works
Case-Control Designs in the Study of Common Diseases: Updates on the Demise of the Rare Disease Assumption and the Choice of Sampling Scheme for Controls
RODRIGUES, L., & KIRKWOOD, B. R. (1990) · International Journal of Epidemiology · doi:10.1093/ije/19.1.205 · Cited by 207 · see citing works
Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin‐receptor status
Peschke, E., Frese, T., Chankiewitz, E., Peschke, D., Preiß, U., Schneyer, U., Spessert, R., & Mühlbauer, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00287.x · Cited by 197 · see citing works
Function and expression of melatonin receptors on human pancreatic islets
Ramracheya, R. D., Muller, D. S., Squires, P. E., Brereton, H., Sugden, D., Huang, G. C., Amiel, S. A., Jones, P. M., & Persaud, S. J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00523.x · Cited by 186 · see citing works
Epidemiology of Uriniary Melatonin in Women and Its Relation to Other Hormones and Night Work
Stevens, R. G. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0420 · Cited by 184 · see citing works
Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice
Sartori, C. S., Dessen, P., Mathieu, C., Monney, A., Bloch, J., NICOD, P. H., Scherrer, U., & Duplain, H. (2009) · Endocrinology · doi:10.1210/en.2009-0425 · Cited by 164 · see citing works
Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels?
Schernhammer, E. S., & Schulmeister, K. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601626 · Cited by 161 · see citing works
Prediction of nocturnal plasma melatonin from morning urinary measures
Graham, C. H., Cook, M. R., Kavet, R. I., Sastre, A., & Smith, D. K. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00538.x · Cited by 150 · see citing works
New evidence for a role of melatonin in glucose regulation
Peschke, E., & Mühlbauer, E. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.09.001 · Cited by 137 · see citing works
Activation of insulin and IGF‐1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets
Picinato, M. C., Hirata, A. E., Cipolla‐Neto, J., Curi, R., Carvalho, C. R. D. O., Anhê, G. F., & Carpinelli, Â. R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00493.x · Cited by 124 · see citing works
Urinary Melatonin Levels and Postmenopausal Breast Cancer Risk in the Nurses' Health Study Cohort
Schernhammer, E. S., & Hankinson, S. E. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0637 · Cited by 123 · see citing works
Self-citation
Association Between Physical Activity and Risk of Bleeding in Children With Hemophilia
Broderick, C. R., Herbert, R., Latimer, J., Barnes, C. D., Curtin, J. A., Mathieu, E., Monagle, P., & Brown, S. A. (2012) · JAMA · doi:10.1001/jama.2012.12727 · Cited by 123 · see citing works
Identification and functional characterization of melatonin Mel 1a receptors in pancreatic β cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling
Kemp, D. M., Ubeda, M., & Habener, J. F. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00064-3 · Cited by 122 · see citing works
Daily and Annual Rhythms in Human Melatonin Secretion: Role in Puberty Control
Waldhauser, F., & Dietzel, M. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb11811.x · Cited by 121 · see citing works
The diabetogenic potential of thiazide-type diuretic and beta-blocker combinations in patients with hypertension
Mason, J. M., Dickinson, H. O., Nicolson, D. J., Campbell, F., Ford, G. A., & Williams, B. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000177537.91527.09 · Cited by 100 · see citing works
Melatonin Effect on Rat Body Weight Regulation in Response to High-Fat Diet at Middle Age
Puchalski, S. S., Green, J. N., & Rasmussen, D. D. (2003) · Endocrine · doi:10.1385/endo:21:2:163 · Cited by 88 · see citing works
Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
Ramos, E., Chen, G., Shriner, D., Doumatey, A. P., Gerry, N. P., Herbert, A. G., Huang, H., Zhou, J., Christman, M. F., Adeyemo, A., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-2002-7 · Cited by 87 · see citing works
Prospective Study of Recreational Physical Activity and Ovarian Cancer
Bertone, E. R., Willett, W. C., ROSNER, B. A., Hunter, D. J., Fuchs, C. S., Speizer, F. E., Colditz, G. A., & Hankinson, S. E. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.12.942 · Cited by 79 · see citing works
Nocturnal melatonin plasma levels in patients with OSAS: the effect of CPAP
Hernández, C., Abreu, J., Abreu, P. M., Castro, A., & Jiménez, A. (2007) · European Respiratory Journal · doi:10.1183/09031936.00051906 · Cited by 76 · see citing works
Radioimmunological Determination of Urinary Melatonin in Humans: Correlation with Plasma Levels and Typical 24-Hour Rhythmicity*
Lang, U., Kornemark, M., Aubert, M. L., & Sizonenko, P. C. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-3-645 · Cited by 76 · see citing works
Melatonin–insulin interactions in patients with metabolic syndrome
Robeva, R. N., Кirilov, G., Tomova, A., & Kumanov, P. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00527.x · Cited by 76 · see citing works
Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese
Ohshige, T., Iwata, M., Omori, S., Tanaka, Y., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Kashiwagi, A., Kawamori, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026911 · Cited by 75 · see citing works
Alteration of melatonin secretion in patients with type 2 diabetes and proliferative diabetic retinopathy
Hikichi, T., Tateda, N., & Miura, T. (2011) · Clinical ophthalmology · doi:10.2147/opth.s19559 · Cited by 74 · see citing works
Sulphatoxymelatonin excretion in older people: Relationship to plasma melatonin and renal function
Basket, J. J., Cockrem, J. F., & Antunovich, T. A. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00366.x · Cited by 71 · see citing works
Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)
Cuesta‐Sancho, S., Kireev, R. A., Garcı́a, C., Rancán, L., Vara, E., & Tresguerres, J. A. F. (2012) · AGE · doi:10.1007/s11357-012-9397-7 · Cited by 67 · see citing works
Comparison of Diets of Diabetic and Nondiabetic Women
Shimakawa, T., Herrera-Acena, M. G., Colditz, G. A., Manson, J. E., Stamper, M. J., & Willett, W. C. (1993) · Diabetes Care · doi:10.2337/diacare.16.10.1356 · Cited by 42 · see citing works
A Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart Disease
Stampfer, M. J., Willett, W. C., Colditz, G. A., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1986) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198605000-00017 · Cited by 30 · see citing works
Low testosterone levels and unimpaired melatonin secretion in young males with metabolic syndrome
Robeva, R. N., Кirilov, G., Tomova, A., & Kumanov, P. (2006) · Andrologia · doi:10.1111/j.1439-0272.2006.00743.x · Cited by 30 · see citing works
Longitudinal Associations between Endogenous Melatonin Production and Reported Sleep Duration from Childhood to Early Adulthood
Diethelm, K., Libuda, L., Bolzenius, K., Griefahn, B., Buyken, A. E., & Remer, T. (2010) · Hormone Research in Paediatrics · doi:10.1159/000303134 · Cited by 20 · see citing works
Long-Term Stability of 6-Hydroxymelatonin Sulfate in 24-h Urine Samples Stored at -20°C
Griefahn, B., Remer, T., Blaszkewicz, M., & Bröde, P. (2001) · Endocrine · doi:10.1385/endo:15:2:199 · Cited by 12 · see citing works

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Tähkämö, L., Partonen, T., & Pesonen, A.-K. (2019) · Chronobiology International · doi:10.1080/07420528.2018.1527773 · Cited by 480 · see citing works
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Weeda, S. M., Zhang, N., Zhao, X., Ndip, G. M., Guo, Y., Buck, G. A., Fu, C., & Ren, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093462 · Cited by 381 · see citing works
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Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes
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Lou, S., Lee, H. M., Qin, H., Li, J., Gao, Z., Liu, X., Chan, L. L., Lam, V. K. L., So, W., Wang, Y., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0408-0 · Cited by 198 · see citing works
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Consequences of Circadian Disruption on Cardiometabolic Health
Reutrakul, S., & Knutson, K. L. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.07.005 · Cited by 163 · see citing works
Diet, Lifestyle, and Genetic Risk Factors for Type 2 Diabetes: A Review from the Nurses’ Health Study, Nurses’ Health Study 2, and Health Professionals’ Follow-Up Study
Ardisson Korat, A. V., Willett, W. C., & Hu, F. B. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0103-5 · Cited by 162 · see citing works
Circadian disruption and human health: A bidirectional relationship
Abbott, S. M., Malkani, R. G., & Zee, P. C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14298 · Cited by 161 · see citing works
Association between short and long sleep durations and cardiovascular outcomes: a systematic review and meta-analysis
Krittanawong, C., Tunhasiriwet, A., Wang, Z., Zhang, H., Farrell, A. M., Chirapongsathorn, S., Sun, T., Kitai, T., & Argulian, E. (2017) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872617741733 · Cited by 162 · see citing works
Physiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158 · see citing works
Evening light exposure to computer screens disrupts human sleep, biological rhythms, and attention abilities
Green, A., Cohen-Zion, M., Haim, A., & Dagan, Y. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1324878 · Cited by 158 · see citing works
Light exposure during sleep impairs cardiometabolic function
Mason, I. C., Grimaldi, D., Reid, K. J., Warlick, C., Malkani, R. G., Abbott, S. M., & Zee, P. C. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113290119 · Cited by 151 · see citing works
Sleep habits and diabetes
Larcher, S., Benhamou, P., Pépin, J., & Borel, A. (2015) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.12.004 · Cited by 134 · see citing works
Timing and Intensity of Light Correlate with Body Weight in Adults
Reid, K. J., Santostasi, G., Baron, K. G., Wilson, J. A., Kang, J., & Zee, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092251 · Cited by 119 · see citing works
Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet
Yin, J., Li, Y., Han, H. L., Ma, J., Liu, G., Wu, X., Huang, X., Fang, R., Baba, K., Bin, P., et al. (2020) · mSystems · doi:10.1128/msystems.00002-20 · Cited by 120 · see citing works
Reduced silent information regulator 1 signaling exacerbates myocardial ischemia–reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
Yu, L., Liang, H., Dong, X., Zhao, G., Jin, Z., Zhai, M., Yang, Y., Chen, W., Liu, J., Yi, W., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12269 · Cited by 119 · see citing works
Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism
Owino, S., Buonfiglio, D. D. C., Tchio, C. I. M., & Tosini, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00488 · Cited by 124 · see citing works
Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers
Gil‐Lozano, M., Hunter, P. M., Behan, L., Gladanac, B., Casper, R. F., & Brubaker, P. L. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00298.2015 · Cited by 114 · see citing works
Association Between Sleep Timing, Obesity, Diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Cohort Study
Knutson, K. L., Wu, D., Patel, S. R., Loredo, J. S., Redline, S. S., Cai, J., Gallo, L. C., Mossavar‐Rahmani, Y., Ramos, A. R., Teng, Y., et al. (2017) · SLEEP · doi:10.1093/sleep/zsx014 · Cited by 113 · see citing works
G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus
Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. M., & Langmead, C. J. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014373 · Cited by 108 · see citing works
Connecting insufficient sleep and insomnia with metabolic dysfunction
Duan, D., Kim, L. J., Jun, J. C., & Polotsky, V. Y. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14926 · Cited by 110 · see citing works
Contribution of the Nurses’ Health Studies to Uncovering Risk Factors for Type 2 Diabetes: Diet, Lifestyle, Biomarkers, and Genetics
Ley, S. H., Korat, A. V. A., Sun, Q., Tobias, D. K., Zhang, C., Qi, L., Willett, W. C., Manson, J. E., & Hu, F. B. (2016) · American Journal of Public Health · doi:10.2105/ajph.2016.303314 · Cited by 100 · see citing works
Effect of Light and Melatonin and Other Melatonin Receptor Agonists on Human Circadian Physiology
Emens, J. S., & Burgess, H. J. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.001 · Cited by 102 · see citing works
Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
Song, S. O., He, K., Narla, R. R., Kang, H. G., Ryu, H. U., & Boyko, E. J. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.0256 · Cited by 101 · see citing works
Light at night in older age is associated with obesity, diabetes, and hypertension
Kim, M., Vu, T. T., Maas, M. B., Braun, R., Wolf, M. S., Roenneberg, T., Daviglus, M. L., Reid, K. J., & Zee, P. C. (2022) · SLEEP · doi:10.1093/sleep/zsac130 · Cited by 100 · see citing works
Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease
Nikolaev, G., Robeva, R. N., & Konakchieva, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010471 · Cited by 96 · see citing works
Sleep Apnea, Obesity, and Disturbed Glucose Homeostasis: Epidemiologic Evidence, Biologic Insights, and Therapeutic Strategies
Pugliese, G., Barrea, L., Laudisio, D., Salzano, C., Aprano, S., Colao, A., Savastano, S., & Muscogiuri, G. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00369-y · Cited by 94 · see citing works
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology
Lane, J. M., Chang, A., Bjonnes, A., Aeschbach, D., Anderson, C., Cade, B. E., Cain, S. W., Czeisler, C. A., Gharib, S. A., Gooley, J. J., et al. (2016) · Diabetes · doi:10.2337/db15-0999 · Cited by 95 · see citing works
Circadian desynchrony and glucose metabolism
Speksnijder, E. M., Bisschop, P. H. L. T., Siegelaar, S. E., Stenvers, D. J., & Kalsbeek, A. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12956 · Cited by 98 · see citing works
Night‐shift work is associated with poorer glycaemic control in patients with type 2 diabetes
Manodpitipong, A., Saetung, S., Nimitphong, H., Siwasaranond, N., Wongphan, T., Sornsiriwong, C., Luckanajantachote, P., Mangjit, P., Keesukphan, P., Crowley, S. J., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12554 · Cited by 92 · see citing works
Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?
Jiki, Z., Lecour, S., & Nduhirabandi, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00528 · Cited by 88 · see citing works
Physiology of the Pineal Gland and Melatonin
Aulinas, A. (2019) · Europe PMC (PubMed Central) · Cited by 88 · see citing works
Independent and joint associations of dietary antioxidant intake with risk of post-stroke depression and all-cause mortality
Xu, Q., Qian, X., Sun, F., Liu, H., Dou, Z., & Zhang, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.013 · Cited by 91 · see citing works
The Interlinked Rising Epidemic of Insufficient Sleep and Diabetes Mellitus
Chattu, V. K., Chattu, S. K., Burman, D., Spence, D. W., & Pandi-Perumal, S. R. (2019) · Healthcare · doi:10.3390/healthcare7010037 · Cited by 87 · see citing works
A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms
Strohmaier, S., Devore, E. E., Zhang, Y., & Schernhammer, E. S. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1102-5 · Cited by 88 · see citing works
Activation of melatonin signaling promotes β-cell survival and function
Costes, S., Boss, M., Thomas, A. P., & Matveyenko, A. V. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1293 · Cited by 84 · see citing works
Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI 3K activity
Owino, S., Sánchez‐Bretaño, A., Tchio, C. I. M., Cecon, E., Karamitri, A., Dam, J., Jockers, R., Piccione, G. G., Noh, H. L., Kim, T., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12462 · Cited by 85 · see citing works
Melatonin synthesis impairment as a new deleterious outcome of diabetes‐derived hyperglycemia
do Amaral, F. G., Turati, A. D. O., Barone, M. T. U., Scialfa, J. H., Buonfiglio, D. D. C., Peres, R., Garcia, R. A. P., Afeche, S. C., Lima, L. D. S., Scavone, C., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12144 · Cited by 83 · see citing works
Melatonin redirects carbohydrates metabolism during sugar starvation in plant cells
Kobylińska, A., Borek, S., & Posmyk, M. M. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12466 · Cited by 82 · see citing works
Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha‐2‐ HS ‐glycoprotein
Heo, J., Yoon, D. W., Yu, J. H., Kim, N. H., Yoo, H. J., Seo, J. A., Kim, S. G., Choi, K. M., Baik, S. H., Choi, D. S., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12493 · Cited by 80 · see citing works
Chronomedicine and type 2 diabetes: shining some light on melatonin
Forrestel, A. C., Miedlich, S. U., Yurcheshen, M. E., Wittlin, S. D., & Sellix, M. T. (2016) · Diabetologia · doi:10.1007/s00125-016-4175-1 · Cited by 80 · see citing works
Change in Sleep Duration and Type 2 Diabetes: The Whitehall II Study
Ferrie, J. E., Mika Kivimaki, B., Akbaraly, T. N., Tabák, Á. G., Abell, J. G., Smith, G. D., Virtanen, M., Meena Kumari, B., & Shipley, M. J. (2015) · Diabetes Care · doi:10.2337/dc15-0186 · Cited by 76 · see citing works
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial
Garaulet, M., Lopez-Minguez, J., Dashti, H. S., Vetter, C., Hernández-Martínez, A. M., Pérez-Ayala, M., Baraza, J. C., Wang, W., Florez, J. C., Scheer, F. A. J. L., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1314 · Cited by 77 · see citing works
Later chronotype is associated with higher hemoglobin A1c in prediabetes patients
Anothaisintawee, T., Lertrattananon, D., Thamakaison, S., Knutson, K. L., Thakkinstian, A., & Reutrakul, S. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1279624 · Cited by 75 · see citing works
Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial
Goyal, A., Terry, P., Superak, H. M., Nell‐Dybdahl, C., Chowdhury, R., Phillips, L. S., & Kutner, M. H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-124 · Cited by 74 · see citing works
Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3‐L1 preadipocytes
Kato, H., Tanaka, G., Masuda, S., Ogasawara, J., Sakurai, T., Kizaki, T., Ohno, H., & Izawa, T. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12259 · Cited by 72 · see citing works
Melatonin and metabolic regulation: a review
Navarro‐Alarcón, M., Ruiz‐Ojeda, F. J., Blanca-Herrera, R. M., A‐Serrano, M. M., Acuña-Castroviejo, D., Fernández‐Vázquez, G., & Agil, A. (2014) · Food & Function · doi:10.1039/c4fo00317a · Cited by 76 · see citing works
Aiding sleep in type 2 diabetes: therapeutic considerations
Tan, X., van Egmond, L., Chapman, C. D., Cedernaes, J., & Benedict, C. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30233-4 · Cited by 72 · see citing works
Impact of sleep behavior on glycemic control in type 1 diabetes: the role of social jetlag
Larcher, S., Gauchez, A., Lablanche, S., Pépin, J., Benhamou, P., & Borel, A. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0188 · Cited by 72 · see citing works
Enhancement of high glucose‐induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT 2 /Akt/NF‐κB pathway
Onphachanh, X., Lee, H. J., Lim, J. R., Jung, Y. H., Kim, J. S., Chae, C. W., Lee, S., Gabr, A. A., & Han, H. J. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12427 · Cited by 71 · see citing works
The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
Ostadmohammadi, V., Soleimani, A., Bahmani, F., Aghadavod, E., Ramezani, R., Reiter, R. J., Mansournia, M. A., Banikazemi, Z., Soleimani, M., Zaroudi, M., et al. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2019.08.003 · Cited by 70 · see citing works
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome
Li, S., Zhai, J., Chu, W., Geng, X., Chen, Z., & Du, Y. (2020) · Translational research · doi:10.1016/j.trsl.2020.02.003 · Cited by 69 · see citing works
Melatonin, mitochondria, and the metabolic syndrome
Cardinali, D. P., & Vigo, D. E. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2611-0 · Cited by 70 · see citing works
New insights into the function of melatonin and its role in metabolic disturbances
do Amaral, F. G., Andrade-Silva, J., Kuwabara, W. M. T., & Cipolla‐Neto, J. (2019) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1631158 · Cited by 66 · see citing works
Human Gastroenteropancreatic Expression of Melatonin and Its Receptors MT1 and MT2
Söderquist, F., Hellström, P. M., & Cunningham, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120195 · Cited by 65 · see citing works
Melatonin Increases Brown Adipose Tissue Volume and Activity in Patients With Melatonin Deficiency: A Proof-of-Concept Study
Halpern, B., Mancini, M. C., Bueno, C., de Barcelos, I. P., de Melo, M. E., Lima, M. S., Carneiro, C. D. G., Sapienza, M. T., Buchpiguel, C. A., do Amaral, F. G., et al. (2019) · Diabetes · doi:10.2337/db18-0956 · Cited by 64 · see citing works
Novel therapeutics for type 2 diabetes: insulin resistance
Altaf, Q. A., Barnett, A. H., & Tahrani, A. A. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12400 · Cited by 64 · see citing works
Night workers with circadian misalignment are susceptible to alcohol-induced intestinal hyperpermeability with social drinking
Swanson, G. R., Gorenz, A., Shaikh, M. W., Desai, V., Kaminsky, T. J., van den Berg, J., Murphy, T. E., Raeisi, S., Fogg, L., Vitaterna, M. H., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00087.2016 · Cited by 63 · see citing works
Type 2 diabetes–associated variants of the MT 2 melatonin receptor affect distinct modes of signaling
Karamitri, A., Plouffe, B., Bonnefond, A., Chen, M., Gallion, J., Guillaume, J.-L., Hegron, A., Boissel, M., Canouil, M., Langenberg, C., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aan6622 · Cited by 62 · see citing works
Diabetes Pathology and Risk of Primary Open-Angle Glaucoma: Evaluating Causal Mechanisms by Using Genetic Information
Shen, L., Walter, S., Melles, R. B., Glymour, M. M., & Jorgenson, E. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv204 · Cited by 62 · see citing works
Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2Receptor Variants with Type 2 Diabetes
Karamitri, A., Renault, N., Clément, N., Guillaume, J., & Jockers, R. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1101 · Cited by 61 · see citing works
Melatonin in Heart Failure: A Promising Therapeutic Strategy?
Nduhirabandi, F., & Maarman, G. J. (2018) · Molecules · doi:10.3390/molecules23071819 · Cited by 61 · see citing works
Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19
Tan, D. X., & Hardeland, R. (2020) · Molecules · doi:10.3390/molecules25194410 · Cited by 60 · see citing works
Circadian Disruption and Diet-Induced Obesity Synergize to Promote Development of β-Cell Failure and Diabetes in Male Rats
Qian, J., Yeh, B., Rakshit, K., Colwell, C. S., & Matveyenko, A. V. (2015) · Endocrinology · doi:10.1210/en.2015-1516 · Cited by 59 · see citing works
Circadian rhythms, insulin action, and glucose homeostasis
Tan, E., & SCOTT, E. M. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000061 · Cited by 58 · see citing works
Circadian transcription from beta cell function to diabetes pathophysiology
Perelis, M., Ramsey, K. M., Marcheva, B., & Bass, J. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416656949 · Cited by 57 · see citing works
Diabetes mellitus and melatonin: Where are we?
Patel, R., PARMAR, N. R., Palit, S. P., RATHWA, N. N., Ramachandran, A. V., & Begum, R. (2022) · Biochimie · doi:10.1016/j.biochi.2022.01.001 · Cited by 58 · see citing works
Salivary melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis
Shimada, M., Seki, H., Samejima, M., Hayase, M., & Shirai, F. (2016) · BioScience Trends · doi:10.5582/bst.2015.01123 · Cited by 55 · see citing works
Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host
Swanson, G. R., Siskin, J., Gorenz, A., Shaikh, M. W., Raeisi, S., Fogg, L., Forsyth, C. B., & Keshavarzian, A. (2020) · Translational research · doi:10.1016/j.trsl.2020.04.004 · Cited by 57 · see citing works
Type 2 diabetes and cardiovascular disease: what next?
Joseph, J. J., & Golden, S. H. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000044 · Cited by 57 · see citing works
Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials
Delpino, F. M., Figueiredo, L. M., & Nunes, B. P. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.06.007 · Cited by 56 · see citing works
Obstructive sleep apnoea and diabetes: an update
Tahrani, A., Ali, A., & Stevens, M. (2013) · Current opinion in pulmonary medicine · doi:10.1097/mcp.0b013e3283659da5 · Cited by 54 · see citing works
Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
Kimple, M. E., Neuman, J. C., Linnemann, A. K., & Casey, P. J. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.40 · Cited by 54 · see citing works
Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats
Thomas, A. P., Hoang, J. D., Vongbunyong, K. E., Nguyen, A., Rakshit, K., & Matveyenko, A. V. (2016) · Endocrinology · doi:10.1210/en.2016-1309 · Cited by 54 · see citing works
Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus
Gubin, D. G., Nelaeva, A. A., Uzhakova, A. E., Хасанова, Ю. В., Cornélissen, G., & Weinert, D. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1347670 · Cited by 54 · see citing works
Incident Type 2 Diabetes Among Individuals With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Jepson, C., Hsu, J. Y., Fischer, M. J., Kusek, J. W., Lash, J. P., Ricardo, A. C., Schelling, J. R., Feldman, H. I., Appel, L. J., Feldman, H. I., et al. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.06.017 · Cited by 52 · see citing works
The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Doosti-Irani, A., Ostadmohammadi, V., Mirhosseini, N., Mansournia, M., Reiter, R., Kashanian, M., Rahimi, M., Razavi, M., & Asemi, Z. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0752-8462 · Cited by 52 · see citing works
Decreased melatonin secretion is associated with increased intestinal permeability and marker of endotoxemia in alcoholics
Swanson, G. R., Gorenz, A., Shaikh, M. W., Desai, V., Forsyth, C. B., Fogg, L., Burgess, H. J., & Keshavarzian, A. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00002.2015 · Cited by 52 · see citing works
Melatonin Affects Mitochondrial Fission/Fusion Dynamics in the Diabetic Retina
Chang, J. Y.-A., Yu, F., Shi, L., Ko, M. L., & Ko, G. Y. ‐. (2019) · Journal of Diabetes Research · doi:10.1155/2019/8463125 · Cited by 52 · see citing works
Sleep Duration Patterns in Early to Middle Adulthood and Subsequent Risk of Type 2 Diabetes in Women
Baden, M. Y., Hu, F. B., Vetter, C., Schernhammer, E. S., Redline, S. S., & Huang, T. (2020) · Diabetes Care · doi:10.2337/dc19-2371 · Cited by 55 · see citing works
Pleiotropic Effects of Melatonin
Mahmood, D. (2019) · Drug Research · doi:10.1055/a-0656-6643 · Cited by 52 · see citing works
Melatonin and Male Reproductive Health: Relevance of Darkness and Antioxidant Properties
Rocha, C. S. F., Rato, L., Martins, A. D., Alves, M. G., & Oliveira, P. F. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150505155530 · Cited by 49 · see citing works
Cross-sectional and Prospective Associations between Sleep Regularity and Metabolic Health in the Hispanic Community Health Study/Study of Latinos.
Fritz, J., Phillips, A., Hunt, L., Imam, A., Reid, K., Perreira, K., Mossavar-Rahmani, Y., Daviglus, M., Sotres-Alvarez, D., Zee, P., et al. (2020) · Sleep · doi:10.1093/sleep/zsaa218 · Cited by 36 · see citing works
Transcutaneous Vagus Nerve Stimulation Induces Tidal Melatonin Secretion and Has an Antidiabetic Effect in Zucker Fatty Rats
Wang, S., Zhai, X., Li, S., McCabe, M. F., Wang, X., & Rong, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124195 · Cited by 47 · see citing works

Nocturnal melatonin secretion and risk of type 2 diabetes: a prospective cohort study
Smith, E. S., Franzén, A., Pihlsgård, M., Nilsson, P. M., Timpka, S., & Enhörning, S. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf667 · Cited by 2 · see citing works
Melatonin,its receptor and type 2 diabetes
孙东, & 李明龙 (2012) · Intern J Endocrinol Metab · doi:10.3760/cma.j.issn.1673-4157.2012.01.017
Increased melatonin signaling is a risk factor for type 2 diabetes
Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A.-K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.009 · Cited by 262 · see citing works
糖尿病相关的新陈代谢的混乱上的 melatonin 的角色
Javier, J., Espino, José, Pariente, Ana, A., & Rodríguez (2011)
Role of melatonin on diabetes-related metabolic disorders
Espino, J. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i6.82 · Cited by 118 · see citing works

Authors: McMullan, C. J., Schernhammer, E. S., Rimm, E. B., Hu, F. B., & Forman, J. P.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: McMullan, Ciaran J.
ORCID: McMullan, Ciaran J.
Schernhammer, Eva S.
Rimm, Eric B.
Hu, Frank B.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2013-04-03
Volume: 309
Issue: 13
Pages: 1388
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2013.2710
PMC: PMC3804914
OpenAlex: W2086677877
Cited by: 369
References: 54
Citations by year: 2026: 15 · 2025: 21 · 2024: 18 · 2023: 30 · 2022: 29 · 2021: 26 · 2020: 36 · 2019: 25 · 2018: 43 · 2017: 24 · 2016: 28 · 2015: 39 · 2014: 28 · 2013: 6
FWCI: 18.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Heart, Lung, and Blood Institute (R01HL103607, HL103607)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058845, DK58845)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: melatonin secretion, type 2 diabetes, 6-sulfatoxymelatonin, urinary melatonin metabolites, insulin resistance, diabetes risk, women, sleep quality, inflammation, endothelial dysfunction
MeSH terms: Aged, Creatinine, Diabetes Mellitus, Type 2, Female, Humans, Melatonin, Middle Aged, Regression Analysis, Risk Factors, United States, Cohort Studies, Incidence, Case-Control Studies

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Melatonin secretion and the incidence of type 2 diabetes

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