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Cited by 139Circadian rhythm and melatoninPancreatic function and diabetesDiabetes Treatment and Management

Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women

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Cagnacci, Angelo, Arangino, Serenella, Renzi, Antonietta, Paoletti, Anna Maria, Melis, Gian Benedetto, Cagnacci, Paolo, Volpe, Annibale·2001·Clinical Endocrinology
DOI 10.1046/j.1365-2265.2001.01232.x
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Abstract

OBJECTIVE: The effect of melatonin on human carbohydrate metabolism is not yet clear. We investigated whether melatonin influences glucose tolerance and insulin sensitivity in aged women. PATIENTS: Twenty-two postmenopausal women of whom 14 were on hormone replacement therapy. DESIGN: After an overnight fast, at 0800 hours on two nonconsecutive days, placebo or melatonin (1 mg) were administered randomly and in a double blind fashion. Forty-five minutes later, an oral glucose tolerance test (75 g; OGTT) was performed in 13 women. In another nine women insulin-dependent (Si) and -independent (Sg) glucose utilization was tested by a frequently sampled intravenous glucose tolerance test (FSIGT). RESULTS: Areas under the response curve to OGTT (AUC) for glucose (1420 +/- 59 vs. 1250 +/- 55 mmol x min/l; P < 0.01), and C-peptide (42,0980 +/- 45,320 vs. 33,528 +/- 15,779 pmol x min/l; P < 0.02) were higher following melatonin than placebo, while Si values were lower (2.6 +/- 0.28 units vs. 3.49 +/- 0.4 units; P < 0.03). Si modifications induced by melatonin were inversely related to Si values of the placebo day (r(2) = 0.538; P < 0.025). CONCLUSIONS: The present results indicate that in aged women administration of 1 mg of melatonin reduces glucose tolerance and insulin sensitivity. The present data may have both physiological and clinical implications.

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Authors
Cagnacci, A., Arangino, S., Renzi, A., Paoletti, A. M., Melis, G. B., Cagnacci, P., & Volpe, A.
Corresponding author
Cagnacci, Angelo
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2001-03
Volume
54
Issue
3
Pages
339-346
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1046/j.1365-2265.2001.01232.x
OpenAlex
W1988550244
Cited by
139
References
50
Citations by year
2026: 5 · 2025: 1 · 2024: 12 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 7 · 2013: 5 · 2012: 2
FWCI
1.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (University of Udine) (submittedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
melatonin, glucose tolerance, insulin sensitivity, postmenopausal women, hormone replacement therapy, carbohydrate metabolism, C-peptide, aging
MeSH terms
Analysis of Variance, Blood Glucose, C-Peptide, Estradiol, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Melatonin, Middle Aged, Estrogen Replacement Therapy, Linear Models, Postmenopause, Glucose Intolerance, Area Under Curve

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