The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A randomized, placebo‐controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities
Abstract
Abstract: The purpose of this study was to determine the efficacy of controlled‐release (CR) melatonin in the treatment of delayed sleep phase syndrome and impaired sleep maintenance of children with neurodevelopmental disabilities including autistic spectrum disorders. A randomized double‐blind, placebo‐controlled crossover trial of CR melatonin (5 mg) followed by a 3‐month open‐label study was conducted during which the dose was gradually increased until the therapy showed optimal beneficial effects. Sleep characteristics were measured by caregiver who completed somnologs and wrist actigraphs. Clinician rating of severity of the sleep disorder and improvement from baseline, along with caregiver ratings of global functioning and family stress were also obtained. Fifty‐one children (age range 2–18 years) who did not respond to sleep hygiene intervention were enrolled. Fifty patients completed the crossover trial and 47 completed the open‐label phase. Recordings of total night‐time sleep and sleep latency showed significant improvement of approximately 30 min. Similarly, significant improvement was observed in clinician and parent ratings. There was additional improvement in the open‐label somnolog measures of sleep efficiency and the longest sleep episode in the open‐label phase. Overall, the therapy improved the sleep of 47 children and was effective in reducing family stress. Children with neurodevelopmental disabilities, who had treatment resistant chronic delayed sleep phase syndrome and impaired sleep maintenance, showed improvement in melatonin therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Role of Actigraphy in the Study of Sleep and Circadian Rhythms
Ancoli-Israel, S., Cole, R., Alessi, C., Chambers, M., Moorcroft, W., & Pollak, C. P. (2003) · Sleep · doi:10.1093/sleep/26.3.342 · Cited by 2,751 · cited 1×
“However, CRSD can be accurately diagnosed by actigraphs and somnologs [52].”
BackgroundCross‐over Trials In Clinical Research
Senn, S. (2002) · doi:10.1002/0470854596 · Cited by 653
Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629
Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., & Baker, G. (2006) · BMJ · doi:10.1136/bmj.38731.532766.f6 · Cited by 454
Owens, J. A., Rosen, C. L., & Mindell, J. A. (2003) · PEDIATRICS · doi:10.1542/peds.111.5.e628 · Cited by 214
Cited by
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055
Erland, L. A. E., & Saxena, P. K. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6462 · Cited by 273
The assessment and management of insomnia: an update
Krystal, A. D., Prather, A. A., & Ashbrook, L. H. (2019) · World Psychiatry · doi:10.1002/wps.20674 · Cited by 256
Sleep hygiene for children with neurodevelopmental disabilities
Jan, J. E., Owens, J. A., Weiss, M. D., Johnson, K. P., Wasdell, M. B., Freeman, R. D., & Ipsiroglu, O. S. (2008) · Pediatrics · doi:10.1542/peds.2007-3308 · Cited by 231
Self-citationCarmassi, C., Palagini, L., Caruso, D., Masci, I., Nobili, L., Vita, A., & Dell’Osso, L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00366 · Cited by 220
An update on pharmacotherapy for autism spectrum disorder in children and adolescents
Ji, N. Y., & Findling, R. L. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000132 · Cited by 217
Is Melatonin the Cornucopia of the 21st Century?
Ferlazzo, N., Andolina, G., Cannata, A., Costanzo, M. G., Rizzo, V., Currò, M., Ientile, R., & Caccamo, D. (2020) · Antioxidants · doi:10.3390/antiox9111088 · Cited by 189
Neurotoxins: Free radical mechanisms and melatonin protection
J. Reiter, R., C. Manchester, L., & Tan, D.-X. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246236 · Cited by 179
Individual differences in light sensitivity affect sleep and circadian rhythms
Chellappa, S. L. (2021) · Sleep · doi:10.1093/sleep/zsaa214 · Cited by 163
Tordjman, S., Najjar, I., Bellissant, E., Anderson, G., Barburoth, M., Cohen, D., Jaafari, N., Schischmanoff, O., Fagard, R., Lagdas, E., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020508 · Cited by 132
Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder
Lalanne, S., Fougerou-Leurent, C., Anderson, G. M., Schroder, C. M., Nir, T., Chokron, S., Delorme, R., Claustrat, B., Bellissant, E., Kermarrec, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031490 · Cited by 90
Epidemiology and Management of Insomnia in Children with Autistic Spectrum Disorders
Miano, S., & Ferri, R. (2010) · Pediatric Drugs · doi:10.2165/11316140-000000000-00000 · Cited by 80
Yuge, K., Nagamitsu, S., Ishikawa, Y., Hamada, I., Takahashi, H., Sugioka, H., Yotsuya, O., Mishima, K., Hayashi, M., & Yamashita, Y. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02847-y · Cited by 57
Melatonin in children with autistic spectrum disorders: recent and practical data
Doyen, C., Mighiu, D., Kaye, K., Colineaux, C., Beaumanoir, C., Mouraeff, Y., Rieu, C., Paubel, P., & Contejean, Y. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0162-8 · Cited by 54
Dell’Osso, L., Massoni, L., Battaglini, S., Cremone, I. M., Carmassi, C., & Carpita, B. (2022) · Annals of General Psychiatry · doi:10.1186/s12991-022-00390-6 · Cited by 48
Delayed sleep-wake phase disorder and its related sleep behaviors in the young generation.
Futenma, K., Takaesu, Y., Komada, Y., Shimura, A., Okajima, I., Matsui, K., Tanioka, K., & Inoue, Y. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1174719 · Cited by 42
Psychopharmacology of Autism Spectrum Disorder
Siegel, M. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.07.006 · Cited by 27
A Practice Pathway for the Treatment of Night Wakings in Children with Autism Spectrum Disorder
Galion, A. W., Farmer, J. G., Connolly, H. V., Allhusen, V. D., Bennett, A., Coury, D. L., Lam, J., Neumeyer, A. M., Sohl, K., Witmans, M., et al. (2024) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-023-06026-2 · Cited by 15
Metadata
- Authors
- Wasdell, M. B., Jan, J. E., Bomben, M. M., Freeman, R. D., Rietveld, W. J., Tai, J., Hamilton, D., & Weiss, M. D.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2007-10-18
- Volume
- 44
- Issue
- 1
- Pages
- 57-64
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W1973471819
- Cited by
- 262
- References
- 5
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
