The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Regulation of Arf Activation: the Sec7 Family of Guanine Nucleotide Exchange Factors
Open accessAbstract
The ADP ribosylation factors (Arfs) are a family of small, ubiquitously expressed and evolutionarily conserved guanosine triphosphatases that are key regulators of vesicular transport in eukaryotic cells (D’Souza‐Schorey C, Chavrier P. ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol 2006;7:347–358). Although Arfs are best known for their role in the nucleation of coat protein assembly at a variety of intracellular locations, it is increasingly apparent that they are also integral components in a number of important signaling pathways that are regulated by extracellular cues. The activation of Arfs is catalyzed by a family of guanine nucleotide exchange factors (GEFs), referred to as the Sec7 family, based on homology of their catalytic domains to the yeast Arf GEF, sec7p. While there are only six mammalian Arfs, the human genome encodes 15 Sec7 family members, which can be divided into five classes based on related domain organization. Some of this diversity arises from the tissue‐specific expression of certain isoforms, but all mammalian cells appear to express at least six Arf GEFs, suggesting that Arf activation is under extensive regulatory control. Here we review recent progress in our understanding of the structure, localization and biology of the different classes of Arf GEFs.
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Cites
ARF proteins: roles in membrane traffic and beyond
D'Souza-Schorey, C., & Chavrier, P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1910 · Cited by 1,378
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Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
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A Bacterial Guanine Nucleotide Exchange Factor Activates ARF on Legionella Phagosomes
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Structural Basis for Activation of ARF GTPase
Goldberg, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81754-7 · Cited by 549
Hurtado-Lorenzo, A., Skinner, M., Annan, J. E., Futai, M., Sun-Wada, G.-H., Bourgoin, S., Casanova, J., Wildeman, A., Bechoua, S., Ausiello, D. A., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1348 · Cited by 469
Self-citationTurning on ARF: the Sec7 family of guanine-nucleotide-exchange factors
Jackson, C. L., & Casanova, J. E. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01699-2 · Cited by 468
Self-citationBrefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
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αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule
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Cited by
Regulation of Small GTPases by GEFs, GAPs, and GDIs
Cherfils, J., & Zeghouf, M. (2013) · Physiological Reviews · doi:10.1152/physrev.00003.2012 · Cited by 1,245
ARF family G proteins and their regulators: roles in membrane transport, development and disease
Donaldson, J. G., & Jackson, C. L. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3117 · Cited by 934
Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
Schönthal, A. H. (2012) · Scientifica · doi:10.6064/2012/857516 · Cited by 353
Montagnac, G., Sibarita, J.-B., Loubéry, S., Daviet, L., Romao, M., Raposo, G., & Chavrier, P. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.043 · Cited by 206
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1
Koronakis, V., Hume, P. J., Humphreys, D., Liu, T., Hørning, O., Jensen, O. N., & McGhie, E. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107666108 · Cited by 138
Metadata
- Authors
- Casanova, J. E.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2007-08-07
- Volume
- 8
- Issue
- 11
- Pages
- 1476-1485
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1990130046
- Cited by
- 349
- References
- 77
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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