The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways
Open accessAbstract
Dendritic cells (DCs) express major histocompatibility complex class II (MHC II) to present peptide antigens to T cells. In immature DCs, which bear low cell surface levels of MHC II, peptide‐loaded MHC II is ubiquitinated. Ubiquitination drives the endocytosis and sorting of MHC II to the luminal vesicles of multivesicular bodies (MVBs) for lysosomal degradation. Ubiquitination of MHC II is abrogated in activated DCs, resulting in an increased cell surface expression. We here provide evidence for an alternative MVB sorting mechanism for MHC II in antigen‐loaded DCs, which is triggered by cognately interacting antigen‐specific CD4+ T cells. At these conditions, DCs generate MVBs with MHC II and CD9 carrying luminal vesicles that are secreted as exosomes and transferred to the interacting T cells. Sorting of MHC II into exosomes was, in contrast to lysosomal targeting, independent of MHC II ubiquitination but rather correlated with its incorporation into CD9 containing detergent‐resistant membranes. Together, these data indicate two distinct MVB pathways: one for lysosomal targeting and the other for exosome secretion.
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Exosomes: composition, biogenesis and function
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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
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Self-citationTetraspanin functions and associated microdomains
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Cited by
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Self-citationExtracellular vesicles: Exosomes, microvesicles, and friends
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Self-citationBiogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
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Self-citationRab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N. B., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,750
Self-citationRegulation of immune responses by extracellular vesicles
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Metadata
- Authors
- Buschow, S. I., Nolte‐‘t Hoen, E. N. M., Van Niel, G., Pols, M. S., Ten Broeke, T., Lauwen, M., Ossendorp, F., Melief, C. J. M., Raposo, G., Wubbolts, R., Wauben, M. H. M., & Stoorvogel, W.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2009-09-10
- Volume
- 10
- Issue
- 10
- Pages
- 1528-1542
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W2169599832
- Cited by
- 429
- References
- 61
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Buschow, S. I., Nolte‐‘t Hoen, E. N. M., Van Niel, G., Pols, M. S., Ten Broeke, T., Lauwen, M., Ossendorp, F., Melief, C. J. M., Raposo, G., Wubbolts, R., Wauben, M. H. M., & Stoorvogel, W. (2009). MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways. Traffic. https://doi.org/10.1111/j.1600-0854.2009.00963.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
