Increase of activated mast cells in human endometriosis
Open accessAbstract
Problem: The proliferation of stromal cells in endometriosis promotes extensive adhesion; therefore, the morphological analysis of stromal lesions is important in the investigation of the pathogenesis of endometriosis. Method of Study: In this study, the morphological and numeric comparisons of degranulated mast cells were performed between endometriotic lesions and comparative regions (eutopic endometrium and normal uterine serosa) of patients with and without endometriosis. Results: In cases of endometriosis, diffuse infiltration of numerous mast cells was observed throughout the stromal lesions. These mast cells exhibited degranulation, and scattered granules were also observed. In the eutopic endometrium and normal uterine serosa of both the endometriosis patients and the controls, mast cells were rarely detected. Conclusions: These results suggest that an abnormal immune response, specifically a hypersensitivity reaction, is strongly related to endometriosis; our findings will be helpful in the development of methods for the treatment of endometriosis.
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The content of mast cells in the eutopic endometrium of patients with endometriosis is very low and is not significantly different from that of the endometrium of unaffected patients.
“The capacity of NGF to attract mast cells could explain the higher number of mast cells in endometriotic lesions since it has been shown that the content of mast cells in the eutopic endometrium of patients with endometriosis is very low and is not significantly different from that of the endometrium of unaffected patients (18).”
From Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis (2006) · cites this paper as [18]
The capacity of NGF to attract mast cells could explain the higher number of mast cells in endometriotic lesions.
“The capacity of NGF to attract mast cells could explain the higher number of mast cells in endometriotic lesions since it has been shown that the content of mast cells in the eutopic endometrium of patients with endometriosis is very low and is not significantly different from that of the endometrium of unaffected patients (18).”
From Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis (2006) · cites this paper as [18]
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- Authors
- Sugamata, M., Ihara, T., & Uchiide, I.
- Affiliations
- Omori Red Cross Hospital (JP)
- Corresponding author
- Sugamata, Masao
- Venue
- American Journal of Reproductive Immunology
- Publisher
- Wiley
- Published
- 2005-02-23
- Volume
- 53
- Issue
- 3
- Pages
- 120-125
- ISSN
- 0271-7352 (ISSN-L)
- 1046-7408
- 1600-0897
- OpenAlex
- W2158102618
- Semantic Scholar
- 1e9c032c93533b7733461d0de8e726475d77278a
- Cited by
- 94
- References
- 41
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 7 · 2013: 1 · 2012: 5
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, mast cells, mast cell degranulation, eutopic endometrium, uterine serosa, hypersensitivity, immune response, adhesion, endometriosis pathogenesis
- MeSH terms
- Adult, Endometriosis, Female, Humans, Mast Cells, Microscopy, Electron, Cell Degranulation
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