The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients
Open accessAbstract
Sensitized renal transplant recipients with high levels of donor-specific alloantibody (DSA) commonly develop antibody-mediated rejection (AMR), which may cause acute graft loss or shorten allograft survival. We examined the efficacy of terminal complement inhibition with the humanized anti-C5 antibody, eculizumab, in the prevention AMR in renal transplant recipients with a positive crossmatch against their living donor. The incidence of biopsy-proven AMR in the first 3 months posttransplant in 26 highly sensitized recipients of living donor renal transplants who received eculizumab posttransplant was compared to a historical control group of 51 sensitized patients treated with a similar plasma exchange (PE)-based protocol without eculizumab. The incidence of AMR was 7.7% (2/26) in the eculizumab group compared to 41.2% (21/51) in the control group (p = 0.0031). Eculizumab also decreased AMR in patients who developed high levels of DSA early after transplantation that caused proximal complement activation. With eculizumab, AMR episodes were easily treated with PE reducing the need for splenectomy. On 1-year protocol biopsy, transplant glomerulopathy was found to be present in 6.7% (1/15) eculizumab-treated recipients and in 35.7% (15/42) of control patients (p = 0.044). Inhibition of terminal complement activation with eculizumab decreases the incidence of early AMR in sensitized renal transplant recipients (ClincalTrials.gov number NCT006707).
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Cites
The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria
Hillmen, P., Young, N. S., Schubert, J., Brodsky, R. A., Socié, G., Muus, P., Röth, A., Szer, J., Elebute, M. O., Nakamura, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061648 · Cited by 1,303
Racusen, L. C., Colvin, R. B., Solez, K., Mihatsch, M. J., Halloran, P. F., Campbell, P. M., Cecka, M. J., Cosyns, J., Demetris, A. J., Fishbein, M. C., et al. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00072.x · Cited by 1,060
Preexisting Donor-Specific HLA Antibodies Predict Outcome in Kidney Transplantation
Lefaucheur, C., Loupy, A., Hill, G. S., Andrade, J., Nochy, D., Antoine, C., Gautreau, C., Charron, D., Glotz, D., & Suberbielle-Boissel, C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009101065 · Cited by 789
Rituximab and Intravenous Immune Globulin for Desensitization during Renal Transplantation
Vo, A. A., Lukovsky, M., Toyoda, M., Wang, J., Reinsmoen, N. L., Lai, C.-H., Peng, A., Villicana, R., & Jordan, S. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707894 · Cited by 692
Mauiyyedi, S., Crespo, M., Collins, A. B., Schneeberger, E. E., Pascual, M. A., Saidman, S. L., Tolkoff-Rubin, N. E., Williams, W. W., Delmonico, F. L., Cosimi, A. B., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v133779 · Cited by 492
Stegall, M. D., Gloor, J., Winters, J. L., Moore, S. B., & DeGoey, S. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.01178.x · Cited by 428
Self-citationInhibition of complement activity by humanized anti-C5 antibody and single-chain Fv
Thomas, T. C., Rollins, S. A., Rother, R. P., Giannoni, M. A., Hartman, S. L., Elliott, E. A., Nye, S. H., Matis, L. A., Squinto, S. P., & Evans, M. J. (1996) · Molecular Immunology · doi:10.1016/s0161-5890(96)00078-8 · Cited by 363
Locke, J. E., Magro, C. M., Singer, A. L., Segev, D. L., Haas, M., Hillel, A. T., King, K. E., Kraus, E., Lees, L. M., Melacon, J. K., et al. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02451.x · Cited by 319
Baseline Donor‐Specific Antibody Levels and Outcomes in Positive Crossmatch Kidney Transplantation
Gloor, J. M., Winters, J. L., Cornell, L. D., Fix, L. A., DeGoey, S. R., Knauer, R. M., Cosio, F. G., Gandhi, M. J., Kremers, W., & Stegall, M. D. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02985.x · Cited by 264
Self-citationRinder, C. S., Rinder, H. M., Smith, B. R., Fitch, J. C., Smith, M. J., Tracey, J. B., Matis, L. A., Squinto, S. P., & Rollins, S. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118195 · Cited by 213
Cited by
Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival
Loupy, A., Lefaucheur, C., Vernerey, D., Prugger, C., van Huyen, J.-P. D., Mooney, N., Suberbielle, C., Frémeaux-Bacchi, V., Méjean, A., Desgrandchamps, F., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302506 · Cited by 852
Antibody-Mediated Rejection of Solid-Organ Allografts
Loupy, A., & Lefaucheur, C. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1802677 · Cited by 549
The renaissance of complement therapeutics
Ricklin, D., Mastellos, D. C., Reis, E. S., & Lambris, J. D. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.156 · Cited by 379
Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair
Nieuwenhuijs-Moeke, G. J., Pischke, S. E., Berger, S. P., Sanders, J. S. F., Pol, R. A., Struys, M. M. R. F., Ploeg, R. J., & Leuvenink, H. G. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010253 · Cited by 328
Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage
Franzin, R., Stasi, A., Fiorentino, M., Stallone, G., Cantaluppi, V., Gesualdo, L., & Castellano, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00734 · Cited by 93
Metadata
- Authors
- Stegall, M. D., Diwan, T., Raghavaiah, S., Cornell, L. D., Burns, J., Dean, P. G., Cosio, F. G., Gandhi, M. J., Kremers, W., & Gloor, J. M.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 11
- Issue
- 11
- Pages
- 2405-2413
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1533163737
- Cited by
- 577
- References
- 14
- FWCI
- 39.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients. https://app.cochat.ai/papers/10.1111/j.1600-6143.2011.03757.x
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- Stegall, M. D., Diwan, T., Raghavaiah, S., Cornell, L. D., Burns, J., Dean, P. G., Cosio, F. G., Gandhi, M. J., Kremers, W., & Gloor, J. M. (2011). Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2011.03757.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
