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Relatively strong automatic appetitive action‐tendencies in male carriers of the OPRM1 G‐allele
Open accessAbstract
This study investigated whether automatic approach action tendencies for alcohol‐related stimuli were associated with variation in the mu‐opioid receptor gene (OPRM1), previously related to rewarding effects of alcohol and craving. An adapted approach avoidance task was used, in which participants pulled or pushed a joystick in reaction to the format of a picture shown on the computer screen (e.g. pull landscape pictures and push portrait pictures). Picture size on the screen changed upon joystick movement, so that upon a pull movement picture size increased (creating a sense of approach) and upon a push movement picture size decreased (avoidance). Participants reacted to four categories of pictures: alcohol‐related, other appetitive, general positive and general negative. The sample consisted of 84 heavy drinking young men without a g‐allele in the A118G (or A355G) single nucleotide polymorphism of the OPRM1 gene and 24 heavy drinking young men with at least one g‐allele. Heavy drinking carriers of a g‐allele showed relatively strong automatic approach tendencies for alcohol (approach bias). Unexpectedly, they also showed an approach bias for other appetitive stimuli. No approach bias was found for general positive or negative stimuli. These results suggest that automatic approach tendencies in response to appetitive stimuli could play a role in the etiology of addictive behaviors and related disorders. Further research is needed to investigate the specificity of this approach bias and possible gender differences.
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“The ApBM training procedures used in the beta version were based on existing effective programs (Wiers et al., 2011; Wiers et al., 2009), with adapted stimuli that were likely to be relevant and salient to Australian emerging adults (Onie et al., 2020).”
From Acceptability and Co-Development of an Online Cognitive Bias Modification Intervention for Emerging Adults With Hazardous Alcohol Use and Social Anxiety: A Mixed Methods Study (2020) · cites this paper as Wiers et al., 2009
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“some problem drinkers exhibit an 'approach bias,' where they are drawn to approach alcohol rather than avoid it (Braunstein et al., 2016; Wiers et al., 2009).”
From Acceptability and Co-Development of an Online Cognitive Bias Modification Intervention for Emerging Adults With Hazardous Alcohol Use and Social Anxiety: A Mixed Methods Study (2020) · cites this paper as Wiers et al., 2009
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Self-citationApproach and avoidance in fear of spiders
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Impulse and Self-Control From a Dual-Systems Perspective
Hofmann, W., Friese, M., & Strack, F. (2009) · Perspectives on Psychological Science · doi:10.1111/j.1745-6924.2009.01116.x · Cited by 1,487
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Self-citationImplicit cognition and addiction: a tool for explaining paradoxical behavior
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Self-citationRetraining automatic action-tendencies to approach alcohol in hazardous drinkers.
Wiers, R. W., Rinck, M., Kordts, R., Houben, K., & Strack, F. (2010) · Addiction · doi:10.1111/j.1360-0443.2009.02775.x · Cited by 582
Self-citationWiers, R. W., Gladwin, T. E., Hofmann, W., Salemink, E., & Ridderinkhof, K. R. (2013) · Clinical Psychological Science · doi:10.1177/2167702612466547 · Cited by 486
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Metadata
- Authors
- Wiers, R. W., Rinck, M., Dictus, M., & Van Den Wildenberg, E.
- Affiliations
- Maastricht University (NL)
- Radboud University Nijmegen (NL)
- Corresponding author
- Wiers, R. W.
- ORCID
- Wiers, R. W.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2009-01-28
- Volume
- 8
- Issue
- 1
- Pages
- 101-106
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2122926414
- Cited by
- 377
- References
- 49
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 13 · 2021: 24 · 2020: 59 · 2019: 28 · 2018: 24 · 2017: 21 · 2016: 30 · 2015: 31 · 2014: 21 · 2013: 22 · 2012: 23
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- OPRM1, approach bias, approach-avoidance behavior, alcohol-related stimuli, appetitive stimuli, A118G polymorphism, heavy drinking, alcohol craving, addictive behavior
- MeSH terms
- Adolescent, Adult, Alcohol Drinking, Alleles, Appetite, DNA, Genotype, Heterozygote, Humans, Male, Motivation, Photic Stimulation, Receptors, Opioid, mu, Polymorphism, Single Nucleotide, Young Adult
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