Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder
Abstract
Tryptophan hydroxylase‐1 (TPH1) is the rate‐limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5‐Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right‐handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction. We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele. Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.
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The TPH1 gene A218C polymorphism is associated with increased activation for sad faces.
“A further study has found increased activation for sad faces with the TPH1 gene A218C polymorphism (Lee et al., 2009).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Lee et al., 2009
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Affective Cognition and its Disruption in Mood Disorders
Elliott, R., Zahn, R., Deakin, J. F. W., & Anderson, I. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.77 · Cited by 330 · see citing works
- Authors
- Lee, B. ‐., Lee, H. ‐., Lee, B. ‐., Pae, C. ‐., Yoon, B. ‐., Ryu, S. ‐., Choi, I. ‐., Lee, M. ‐., & Ham, B. ‐.
- Affiliations
- Seoul National University (KR)
- Korea University (KR)
- Kangdong Sacred Heart Hospital (KR)
- Hallym University Hangang Sacred Heart Hospital (KR)
- Corresponding author
- Ham, B.‐J.
- ORCID
- Ham, B.‐J.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2009-07
- Volume
- 8
- Issue
- 5
- Pages
- 512-518
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2001754886
- Cited by
- 11
- References
- 53
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- tryptophan hydroxylase 1, major depressive disorder, amygdala activation, negative facial expressions, serotonin synthesis, genetic susceptibility to depression, gene-environment interaction
- MeSH terms
- Adult, Affect, Amygdala, Brain Chemistry, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, DNA Mutational Analysis, Facial Expression, Female, Gene Frequency, Genetic Testing, Genotype, Humans, Functional Laterality, Magnetic Resonance Imaging, Middle Aged, Neuropsychological Tests, Photic Stimulation, Polymorphism, Genetic, Serotonin, Tryptophan Hydroxylase, Genetic Predisposition to Disease
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