Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation
Abstract
The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.
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Polymorphisms of TPH2 have independent effects on amygdala activation.
“Polymorphisms of the TPH2 gene have been reported to have independent (Brown et al., 2005;Canli et al., 2005) and additive effects with the 5-HTTLPR genotype (Canli et al., 2008;Furmark et al., 2009) on amygdala activation.”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Canli et al., 2005
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- Authors
- Canli, T., Congdon, E., Gutknecht, L., Constable, R. T., & Lesch, K. P.
- Affiliations
- Stony Brook University (US)
- University of Würzburg (DE)
- Yale University (US)
- Venue
- Journal of Neural Transmission
- Published
- 2005-11
- Volume
- 112
- Issue
- 11
- Pages
- 1479-1485
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2162176738
- Cited by
- 188
- References
- 20
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 12 · 2012: 16
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR010710, 5M01-RR-10710)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- tryptophan hydroxylase 2, amygdala, serotonin synthesis, emotion regulation, emotional valence, genetic polymorphism, emotional stimuli
- MeSH terms
- Adolescent, Adult, Amygdala, DNA Mutational Analysis, Emotions, Female, Genetic Markers, Genetic Testing, Genotype, Humans, Magnetic Resonance Imaging, Male, Mutation, Neuropsychological Tests, Photic Stimulation, Serotonin, Tryptophan Hydroxylase, Genetic Variation, Mood Disorders, Genetic Predisposition to Disease
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