Cited by 188Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesStress Responses and Cortisol

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

Canli, T., Congdon, E., Gutknecht, L., Constable, R. T., Lesch, K. P.·2005·Journal of Neural Transmission

Abstract

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

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Crossref · 10.1007/s00702-005-0391-4

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  • Polymorphisms of TPH2 have independent effects on amygdala activation.

    “Polymorphisms of the TPH2 gene have been reported to have independent (Brown et al., 2005;Canli et al., 2005) and additive effects with the 5-HTTLPR genotype (Canli et al., 2008;Furmark et al., 2009) on amygdala activation.”

    From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Canli et al., 2005

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Authors
Canli, T., Congdon, E., Gutknecht, L., Constable, R. T., & Lesch, K. P.
Affiliations
  • Stony Brook University (US)
  • University of Würzburg (DE)
  • Yale University (US)
Venue
Journal of Neural Transmission
Published
2005-11
Volume
112
Issue
11
Pages
1479-1485
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2162176738
Cited by
188
References
20
Citations by year
2026: 2 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 12 · 2012: 16
FWCI
6.63
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (M01RR010710, 5M01-RR-10710)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
tryptophan hydroxylase 2, amygdala, serotonin synthesis, emotion regulation, emotional valence, genetic polymorphism, emotional stimuli
MeSH terms
Adolescent, Adult, Amygdala, DNA Mutational Analysis, Emotions, Female, Genetic Markers, Genetic Testing, Genotype, Humans, Magnetic Resonance Imaging, Male, Mutation, Neuropsychological Tests, Photic Stimulation, Serotonin, Tryptophan Hydroxylase, Genetic Variation, Mood Disorders, Genetic Predisposition to Disease

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