Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication
Open accessAbstract
The amygdala plays a central role in various aspects of affect processing and mood regulation by its rich anatomical connections to other limbic and cortical regions. It is plausible that depressive disorders, and response to antidepressant drugs, may reflect changes in the physiological coupling between the amygdala and other components of affect-related large-scale brain systems. We explored this hypothesis by mapping the functional coupling of right and left amygdalae in functional magnetic resonance imaging data acquired from 19 patients with major depressive disorder and 19 healthy volunteers, each scanned twice (at baseline and 8 weeks later) during performance of an implicit facial affect processing task. Between scanning sessions, the patients received treatment with an antidepressant drug, fluoxetine 20 mg/day. We found that the amygdala was positively coupled bilaterally with medial temporal and ventral occipital regions, and negatively coupled with the anterior cingulate cortex. Antidepressant treatment was associated with significantly increased coupling between the amygdala and right frontal and cingulate cortex, striatum, and thalamus. Treatment-related increases in functional coupling to frontal and other regions were greater for the left amygdala than for the right amygdala. These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico-limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Disruptions in functional coupling between amygdala and subgenual cingulate have been reported during facial processing tasks.
“Finally, disruptions in functional coupling between the amygdala and subgenual cingulate, a region also implicated in assessing the salience of emotion and regulating of emotions, have been reported during facial processing tasks.50,55”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [50]
Chen et al. reported that amygdala-ACC coupling during face emotion recognition increased as symptom severity decreased with antidepressant treatment.
“Chen et al. (2008) described increased amygdala-ACC coupling during face emotion recognition as symptom severity reduced in response to antidepressant treatment.”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Chen et al., 2008
Pregenual ACC-amygdala coupling increases with pharmacological antidepressant treatment.
“the strength of coupling between pregenual ACC and AMY has been shown to increase as a function of treatment with pharmacological antidepressants (Anand et al., 2007; Anand et al., 2005b; Chen et al., 2008)”
From Neural correlates of emotional processing in depression: Changes with cognitive behavioral therapy and predictors of treatment response (2011) · cites this paper as Chen et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Siegel, L. J., & Fletcher‐Janzen, E. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0655 · Cited by 8,468 · see citing works
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Friston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583 · see citing works
Emotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589 · see citing works
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097 · see citing works
Functional and effective connectivity in neuroimaging: a synthesis
Friston, K. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020107 · Cited by 2,452 · see citing works
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.030 · Cited by 2,113 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
KRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977 · see citing works
Neural systems for recognizing emotion
Adolphs, R. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00301-x · Cited by 1,933 · see citing works
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · cited 5× · see citing works
“…secretion of both noradrenaline (Wong et al, 2000) and cortisol (Lopez et al, 1999), which generally have an acute effect of memory enhancement (LaBar and Cabeza, 2006); therefore, together with the presence of amygdala overactivity, the chance that emotionally neutral stimuli are perceived or…”
InfluentialPain and emotion interactions in subregions of the cingulate gyrus
Vogt, B. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1704 · Cited by 1,810 · see citing works
Frackowiak, R. S. J. (1997) · Cited by 1,713 · see citing works
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665 · cited 1× · see citing works
“…amygdala activation when subjects were shown unmasked emotional stimuli (Iidaka et al, 2001; Ohira et al, 2006; Levesque et al, 2003; Phan et al, 2005; Adolphs, 2002) whereas the right amygdala may be activated more in response to subliminally presented stimuli (Adolphs, 2002; Morris et al, 1998).”
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450 · see citing works
Neurophysiological Architecture of Functional Magnetic Resonance Images of Human Brain
Salvador, R. M., John Suckling, A., Coleman, M. R., Pickard, J. D., Menon, D. K., & Bullmore, E. T. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi016 · Cited by 1,334 · see citing works
Self-citationNeuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313 · see citing works
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266 · see citing works
Sheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., & Mintun, M. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01263-x · Cited by 1,191 · see citing works
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187 · see citing works
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115 · see citing works
Bullmore, E. T., Suckling, J., Overmeyer, S., Rabe-Hesketh, S., Taylor, E., & Brammer, M. J. (1999) · IEEE Transactions on Medical Imaging · doi:10.1109/42.750253 · Cited by 1,088 · see citing works
Self-citationThe Anatomical Connections of the Macaque Monkey Orbitofrontal Cortex. A Review
Cavada, C. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.220 · Cited by 917 · see citing works
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., Moore, G. J., Uhde, T. W., & Tancer, M. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.030 · Cited by 892 · see citing works
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859 · see citing works
Cingulate cortex of the rhesus monkey: II. Cortical afferents
Vogt, B. A., & Pandya, D. N. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902620208 · Cited by 854 · see citing works
Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., Mathews, V. P., Kalnin, A., & Lowe, M. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.021 · Cited by 787 · see citing works
Ghashghaei, H. T., & Barbas, H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00446-3 · Cited by 785 · see citing works
Fu, C. H. Y., Williams, S. C. R., Cleare, A. J., Brammer, M. J., Walsh, N. D., Kim, J., Andrew, C. M., Pich, E. M., Williams, P. M., Reed, L. J., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.9.877 · Cited by 775 · see citing works
Self-citationKennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710 · see citing works
Limbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710 · see citing works
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Vollstädt‐Klein, S., Grüsser, S. M., Flor, H., Schumann, G., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1366 · Cited by 700 · see citing works
Neural circuitry underlying voluntary suppression of sadness
Lévesque, J., Eugène, F., Joanette, Y., Paquette, V., Mensour, B., Beaudoin, G., Leroux, J.-M., Bourgouin, P., & Beauregard, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01817-6 · Cited by 689 · see citing works
Goebel, R., Roebroeck, A. F., Kim, D., & Formisano, E. (2003) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2003.08.026 · Cited by 678 · see citing works
Barbas, H. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00245-2 · Cited by 664 · see citing works
Neuroimaging studies of mood disorder effects on the brain
Sheline, Y. I. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00347-0 · Cited by 660 · see citing works
Drevets, W. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00102-5 · Cited by 581 · see citing works
Wong, M., Kling, M. A., Munson, P. J., Listwak, S. J., Licinio, J., Prolo, P., Karp, B., McCutcheon, I. E., Geracioti, T. D., DeBellis, M. D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.325 · Cited by 575 · see citing works
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
Prefrontal cortical-amygdalar metabolism in major depression.
DREVETS, W. C. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09292.x · Cited by 557 · see citing works
Neuroimaging Abnormalities in the Amygdala in Mood Disorders
DREVETS, W. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07098.x · Cited by 544 · see citing works
Network analysis of cortical visual pathways mapped with PET
McIntosh, A. R., Grady, C., Ungerleider, L. G., Haxby, J., Rapoport, S. I., & Horwitz, B. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00655.1994 · Cited by 493 · see citing works
The neural substrates of affective processing in depressed patients treated with venlafaxine
Davidson, R. J., Irwin, W., Anderle, M. J., & Kalin, N. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.64 · Cited by 487 · see citing works
Role of the Amygdala in Decision‐Making
Bechara, A., Damasio, H., & Damasio, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07094.x · Cited by 475 · see citing works
Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00687-6 · Cited by 457 · see citing works
Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
Barden, N. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0421 · Cited by 416 · see citing works
The amygdalostriatal projections in the monkey. An anterograde tracing study
Russchen, F. T., Bakst, I., Amaral, D. G., & Price, J. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90530-x · Cited by 395 · cited 2× · see citing works
“There is strong evidence from anatomical studies in primates that cortical and subcortical components of this system are interconnected and receive projections from the amygdala (Alexander et al, 1986; Russchen et al, 1985; Vogt and Pandya, 1987).”
Neural circuits mediating stress
López, J. F., Akil, H., & Watson, S. J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00266-8 · Cited by 373 · see citing works
Chen, C.-H., Ridler, K., Suckling, J., Williams, S., Fu, C. H. Y., Merlo-Pich, E., & Bullmore, E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.018 · Cited by 354 · see citing works
Self-citationThe amygdala modulates prefrontal cortex activity relative to conditioned fear
Garcia, R., Vouimba, R.-M., Baudry, M., & Thompson, R. F. (1999) · Nature · doi:10.1038/46286 · Cited by 347 · see citing works
Neural systems for behavioral activation and reward
Kalivas, P. W., & Nakamura, M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80031-2 · Cited by 335 · see citing works
Antidepressant Effect on Connectivity of the Mood-Regulating Circuit: An fMRI Study
Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., Mathews, V. P., Kalnin, A., & Lowe, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300725 · Cited by 324 · see citing works
Association of neural and physiological responses during voluntary emotion suppression
Ohira, H., Nomura, M., Ichikawa, N., Isowa, T., Iidaka, T., Sato, A., Fukuyama, S., Nakajima, T., & Yamada, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.047 · Cited by 309 · see citing works
Effect of sertraline on regional metabolic rate in patients with affective disorder
Buchsbaum, M. S., Wu, J. C., Siegel, B. V., Hackett, E., Trenary, M., Abel, L., & Reynolds, C. A. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00097-2 · Cited by 302 · see citing works
Reading vascular changes in brain imaging: is dendritic calcium the key?
Lauritzen, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1589 · Cited by 266 · see citing works
How Good Is Good Enough in Path Analysis of fMRI Data?
Bullmore, E. T., Horwitz, B., Honey, G. D., Brammer, M. J., Williams, S., & Sharma, T. (2000) · NeuroImage · doi:10.1006/nimg.2000.0544 · Cited by 241 · see citing works
Self-citationIidaka, T., Omori, M., Murata, T., Kosaka, H., Yonekura, Y., Okada, T., & Sadato, N. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/089892901753294338 · Cited by 233 · see citing works
Amygdala input to medial prefrontal cortex (mPFC) in the rat: A light and electron microscope study
Bacon, S. J., Headlam, A. J. N., Gabbott, P. L. A., & Smith, A. D. (1996) · Brain Research · doi:10.1016/0006-8993(96)00155-2 · Cited by 191 · see citing works
Wrong, M. (2000) · Medical Entomology and Zoology · Cited by 159 · see citing works
Gabbott, P. L. A., Warner, T., & Busby, S. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.026 · Cited by 133 · see citing works
Pérez-Jaranay, J. M., & Vives, F. (1991) · Brain Research · doi:10.1016/0006-8993(91)91357-7 · Cited by 122 · see citing works
Selective Antidepressants and Cerebrospinal Fluid
Potter, W. Z. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790350045009 · Cited by 117 · see citing works
Modulating limbic-cortical circuits in depression: Targets of antidepressant treatments
Mayberg, H. S. (2002) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2002.35223 · Cited by 102 · see citing works
Permutation tests for factorially designed neuroimaging experiments
John Suckling, A., & Bullmore, E. T. (2004) · Human Brain Mapping · doi:10.1002/hbm.20027 · Cited by 94 · see citing works
Self-citationIrwin, W., Anderle, M. J., Abercrombie, H. C., Schaefer, S. M., Kalin, N. H., & Davidson, R. J. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.057 · Cited by 87 · see citing works
The Functional Brain Connectivity Workshop: report and commentary
Lee, L., Harrison, L. M., & Mechelli, A. (2003) · Network Computation in Neural Systems · doi:10.1088/0954-898x_14_2_201 · Cited by 56 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Aggleton JP (1993). The Amygdala. Oxford University Press Inc.: New York.
Cited by
Sorted by citations
Whole brain resting-state analysis reveals decreased functional connectivity in major depression
Veer, I. M. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00041 · Cited by 753 · see citing works
The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
Vollenweider, F. X., & Kometer, M. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2884 · Cited by 723 · see citing works
Precision psychiatry: a neural circuit taxonomy for depression and anxiety
Williams, L. M. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00579-9 · Cited by 641 · see citing works
Cognitive Mechanisms of Treatment in Depression
Roiser, J. P., Elliott, R., & Sahakian, B. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.183 · Cited by 535 · see citing works
Beddington, J., Cooper, C. L., Field, J., Goswami, U., Huppert, F. A., Jenkins, R., Jones, H. S., Kirkwood, T. B. L., Sahakian, B. J., & Thomas, S. M. (2008) · Nature · doi:10.1038/4551057a · Cited by 554 · see citing works
Rive, M. M., van Rooijen, G., Veltman, D. J., .Phillips, M. L., Schene, A. H., & Ruhé, H. G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.018 · Cited by 481 · see citing works
Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494 · see citing works
Neurocognitive Mechanisms in Depression: Implications for Treatment
Clark, L., Chamberlain, S. R., & Sahakian, B. J. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125618 · Cited by 446 · see citing works
Facial emotion processing in major depression: a systematic review of neuroimaging findings
Stuhrmann, A., Suslow, T., & Dannlowski, U. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-10 · Cited by 440 · see citing works
Self-referential processing, rumination, and cortical midline structures in major depression
Nejad, A. B., Fossati, P., & Lemogne, C. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00666 · Cited by 366 · see citing works
Affective Cognition and its Disruption in Mood Disorders
Elliott, R., Zahn, R., Deakin, J. F. W., & Anderson, I. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.77 · Cited by 330 · see citing works
Ritchey, M., Dolcos, F., Eddington, K. M., Strauman, T. J., & Cabeza, R. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.09.007 · Cited by 320 · see citing works
Almeida, J. R. C. D., Versace, A., Mechelli, A., Hassel, S., Quevedo, K., Kupfer, D. J., & Phillips, M. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.024 · Cited by 305 · see citing works
Systematic review of the neural basis of social cognition in patients with mood disorders
Cusi, A. M., Nazarov, A., Holshausen, K., MacQueen, G. M., & McKinnon, M. C. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100179 · Cited by 278 · see citing works
Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.
Rifkin-Graboi, A., Bai, J., Chen, H., Hameed, W. B., Sim, L. W., Tint, M. T., Leutscher-Broekman, B., Chong, Y.-S., Gluckman, P. D., Fortier, M. V., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.019 · Cited by 258 · see citing works
Prognostic and diagnostic potential of the structural neuroanatomy of depression
Costafreda, S. G., Chu, C., Ashburner, J., & Fu, C. H. Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006353 · Cited by 232 · see citing works
Self-citationSerotonin and emotional processing: does it help explain antidepressant drug action?
Harmer, C. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.036 · Cited by 219 · see citing works
Dannlowski, U., Ohrmann, P., Konrad, C., Domschke, K., Bauer, J., Kugel, H., Hohoff, C., Schöning, S., Kersting, A., Baune, B. T., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008973 · Cited by 216 · see citing works
Perlman, G., Simmons, A. N., Wu, J., Hahn, K. S., Tapert, S. F., Max, J. E., Paulus, M. P., Brown, G. G., Frank, G. K., Campbell-Sills, L., et al. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.01.044 · Cited by 190 · see citing works
Matthews, S. C., Strigo, I. A., Simmons, A. N., Yang, T. T., & Paulus, M. P. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.05.022 · Cited by 190 · see citing works
Functional Connectivity Bias of the Orbitofrontal Cortex in Drug-Free Patients with Major Depression
Frodl, T., Bokde, A. L. W., Scheuerecker, J., Lisiecka, D., Schoepf, V., Hampel, H., Möller, H.-J., Brückmann, H., Wiesmann, M., & Meisenzahl, E. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.022 · Cited by 174 · see citing works
Chepenik, L. G., Raffo, M., Hampson, M., Lacadie, C., Wang, F., Jones, M. M., Pittman, B., Skudlarski, P., & Blumberg, H. P. (2010) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.04.002 · Cited by 175 · see citing works
Townsend, J. D., Eberhart, N. K., Bookheimer, S. Y., Eisenberger, N. I., Foland-Ross, L. C., Cook, I. A., Sugar, C. A., & Altshuler, L. L. (2010) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.06.001 · Cited by 105 · see citing works
5-HTT genotype effect on prefrontal–amygdala coupling differs between major depression and controls
Friedel, E., Schlagenhauf, F., Sterzer, P., Park, S. Q., Bermpohl, F., Ströhle, A., Stoy, M., Puls, I., Hägele, C., Wrase, J., et al. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1536-1 · Cited by 102 · see citing works
Kong, L., Chen, K., Tang, Y., Wu, F., Driesen, N., Womer, F., Fan, G., Ren, L., Jiang, W., Cao, Y., et al. (2013) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.120117 · Cited by 93 · see citing works
Carballedo, A., Amico, F., Ugwu, I., Fagan, A. J., Fahey, C., Morris, D., Meaney, J. F., Leemans, A., & Frodl, T. (2012) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32060 · Cited by 95 · see citing works
Porter, R. J., Bowie, C. R., Jordan, J., & Malhi, G. S. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413502090 · Cited by 85 · see citing works
Ketamine administration reduces amygdalo‐hippocampal reactivity to emotional stimulation
Scheidegger, M., Henning, A., Walter, M., Lehmann, M., Kraehenmann, R., Boeker, H., Seifritz, E., & Grimm, S. (2016) · Human Brain Mapping · doi:10.1002/hbm.23148 · Cited by 79 · see citing works
Altered Intrinsic Functional Brain Architecture in Children at Familial Risk of Major Depression
Chai, X. J., Hirshfeld-Becker, D., Biederman, J., Uchida, M., Doehrmann, O., Leonard, J. A., Salvatore, J., Kenworthy, T., Brown, A., Kagan, E., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.003 · Cited by 75 · see citing works
Neural Correlates of Antidepressant Treatment Response in Adolescents with Major Depressive Disorder
Cullen, K. R., Klimes-Dougan, B., Vu, D. P., Westlund Schreiner, M., Mueller, B. A., Eberly, L. E., Camchong, J., Westervelt, A., & Lim, K. O. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0232 · Cited by 75 · see citing works
Sun, S., Yu, H., Yu, R., & Wang, S. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02625-w · Cited by 69 · see citing works
“Among various EEG connectivity measures, cross-channel coherence evaluates the functional synchronization of cortical connections [55], while cross-frequency coupling (CFC) re fl ects the coordination of low and high frequency brain rhythms that are entrained by both external events and internal…”
Almeida, J. R. C. D., Kronhaus, D. M., Sibille, E. L., Langenecker, S. A., Versace, A., LaBarbara, E. J., & Phillips, M. L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00069 · Cited by 64 · see citing works
The Effect of Antidepressants on Depression After Traumatic Brain Injury: A Meta-analysis
Kreitzer, N., Ancona, R., McCullumsmith, C., Kurowski, B. G., Foreman, B., Ngwenya, L. B., & Adeoye, O. (2019) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000439 · Cited by 56 · see citing works
Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder
Britton, J. C., Stewart, S. E., Killgore, W. D. S., Rosso, I. M., Price, L. M., Gold, A. L., Pine, D. S., Wilhelm, S., Jenike, M. A., & Rauch, S. L. (2010) · Depression and Anxiety · doi:10.1002/da.20718 · Cited by 40 · see citing works
Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder
Faria, V., Åhs, F., Appel, L., Linnman, C., Bani, M., Bettica, P., Pich, E. M., Fredrikson, M., & Furmark, T. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000352 · Cited by 37 · see citing works
Self-citationRuhé, H. G., Koster, M., Booij, J., van Herk, M., Veltman, D. J., & Schene, A. H. (2014) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.12.003 · Cited by 20 · see citing works
Gill, H., Puramat, P., Patel, P., Gill, B., Marks, C. A., Rodrigues, N. B., Castle, D., Cha, D. S., Mansur, R. B., Rosenblat, J. D., et al. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114577 · Cited by 16 · see citing works
Miskowiak, K. W., Svendsen, A. M. B., Harmer, C. J., Elliott, R., Macoveanu, J., Siebner, H. R., Kessing, L. V., & Vinberg, M. (2017) · Psychological Medicine · doi:10.1017/s0033291717000861 · Cited by 14 · see citing works
Lee, B. ‐., Lee, H. ‐., Lee, B. ‐., Pae, C. ‐., Yoon, B. ‐., Ryu, S. ‐., Choi, I. ‐., Lee, M. ‐., & Ham, B. ‐. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2009.00500.x · Cited by 11 · see citing works
Hay, R. E., Reynolds, J. E., Grohs, M., Paniukov, D., Giesbrecht, G. F., Letourneau, N., Dewey, D., & Lebel, C. (2019) · doi:10.1101/692335 · Cited by 7 · see citing works
- Authors
- Chen, C.-H., Suckling, J., Ooi, C., Fu, C. H. Y., Williams, S. C. R., Walsh, N. D., Mitterschiffthaler, M. T., Pich, E. M., & Bullmore, E.
- Affiliations
- University of Cambridge (GB)
- King's College London (GB)
- GlaxoSmithKline (Italy) (IT)
- Venue
- Neuropsychopharmacology
- Published
- 2007-11-07
- Volume
- 33
- Issue
- 8
- Pages
- 1909-1918
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W1963590682
- Cited by
- 224
- References
- 75
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 31 · 2020: 2 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 15 · 2015: 15 · 2014: 12 · 2013: 23 · 2012: 9
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- GlaxoSmithKline
- Wellcome Trust
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, major depressive disorder, antidepressant treatment, fluoxetine, functional coupling, anterior cingulate cortex, medial temporal lobe, hemispheric lateralization, mood regulation
- MeSH terms
- Adult, Amygdala, Analysis of Variance, Brain Mapping, Major Depressive Disorder, Facial Expression, Female, Fluoxetine, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Social Perception, Antidepressive Agents, Second-Generation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
