Clinical application of apolipoprotein E genotyping to Alzheimer's disease
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APOE4 allele increases the risk of developing AD, whereas APOE2 allele is protective.
“APOE4 allele increases the risk of developing AD, whereas APOE2 allele is protective [70, 71].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [70]
The apolipoprotein E e4 allele is harmful, increasing the risk of Alzheimer's disease and hastening the onset of dementia.
“In contrast, the e 4 allele appears to be harmful, increasing the risk of Alzheimer's disease and hastening the onset of dementia.2,5”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [5]
The e4 allele is associated with an increased risk of Alzheimer's disease.
“the e4 allele has been associated with an increased risk of Alzheimer's disease, 1-7”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [5]
The e4 allele is associated with a younger age at the onset of dementia.
“a younger age at the onset of dementia, 2,5”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [5]
The e2 allele is associated with an older age at the onset of dementia.
“an older age at the onset of dementia, 5”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [5]
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Lucotte, G., Aouizérate, A., Gérard, N., Turpin, J. C., & Landais, P. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600617 · Cited by 9 · see citing works
Understanding Alzheimer's disease: Expect more genes and other things
Mayeux, R. P. (1996) · Annals of Neurology · doi:10.1002/ana.410390602 · Cited by 9 · see citing works
Dementia among elderly apolipoprotein E type 4/4 homozygotes: A prospective study
Ganguli, M., Cauley, J. A., DeKosky, S. T., & Kamboh, M. I. (1995) · Genetic Epidemiology · doi:10.1002/gepi.1370120308 · Cited by 8 · see citing works
Apolipoprotein E and Alzheimer’s Disease: State of the Field After Two Years
Roses, A. D., Strittmatter, W. J., Saunders, A. M., Schmechel, D. E., & Pericak‐Vance, M. A. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_1 · Cited by 8 · see citing works
Self-citationApolipoprotein E: Emerging Story in the Pathogenesis of Alzheimer's Disease
Strittmatter, W. J., & Roses, A. D. (1995) · The Neuroscientist · doi:10.1177/107385849500100507 · Cited by 8 · see citing works
Self-citationAltered β‐Amyloid Precursor Protein Isoforms in Mexican Alzheimer’s Disease Patients
Sánchez-González, V., Ortíz, G. G., Gallegos-Arreola, P., Macías-Islas, M. Á., Arias‐Merino, E. D., Loera‐Castañeda, V., Martínez-Cano, E., Velázquez-Brizuela, I. E., Rosales‐Corral, S., Curiel-Ortega, C. R., et al. (2006) · Disease Markers · doi:10.1155/2006/347502 · Cited by 7 · see citing works
Putative Risk Factors for Alzheimer’s Disease
Mayeux, R. P. (2019) · CRC Press eBooks · doi:10.1201/9780429260353-7 · Cited by 7 · see citing works
- Authors
- Roses, A., Strittmatter, W., Pericak-Vance, M., Corder, E., Saunders, A., & Schmechel, D.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1994-06
- Volume
- 343
- Issue
- 8912
- Pages
- 1564-1565
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2049634901
- Cited by
- 125
- References
- 4
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 2 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- apolipoprotein E, APOE genotyping, Alzheimer's disease, genetic risk factors, diagnosis
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Genotype, Humans, Middle Aged
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