The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism
Open accessAbstract
Qualitative impairments in communication, such as delayed language and poor interactive communication skills, are fundamental to the diagnosis of autism. Investigations into social communication in adult BTBR T+tf/J (BTBR) mice are needed to determine whether this inbred strain incorporates phenotypes relevant to the second diagnostic symptom of autism, communication deficits, along with its strong behavioral phenotypes relevant to the first and third diagnostic symptoms, impairments in social interactions and high levels of repetitive behavior. The aim of the present study was to simultaneously measure female urine-elicited scent marking and ultrasonic vocalizations in adult male BTBR mice, in comparison with a standard control strain with high sociability, C57BL/6J (B6), for the assessment of a potential communication deficit in BTBR. Adult male BTBR mice displayed lower scent marking and minimal ultrasonic vocalization responses to female urine obtained from both B6 and BTBR females. Lower scent marking and ultrasonic vocalizations in a social setting by BTBR, as compared with B6, are consistent with the well-replicated social deficits in this inbred mouse strain. Our findings support the interpretation that BTBR incorporate communication deficits, and suggest that scent marking and ultrasonic vocalizations offer promising measures of interest in social cues that may be widely applicable to investigations of mouse models of autism.
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“BTBR T+tf/J (BTBR) is a commercially available inbred strain of mouse that displays behavioral phenotypes relevant to all three diagnostic symptoms of autism (60–62, 64, 66, 68–70, 72, 74–78).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [70]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
Autism From 2 to 9 Years of Age
Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., & Pickles, A. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.694 · Cited by 973 · cited 1×
“Qualitative impairments in communication, such as delayed language and poor conversational skills, are fundamental to the diagnosis of autism (DSM-IV 2000; Frith & Happé 1994; Lord et al. 2001, 2006; Losh & Piven 2007; Volkmar et al. 2004).”
BackgroundPheromones and Animal Behaviour: Communication by Smell and Taste
Wyatt, T. D. (2003) · doi:10.1017/cbo9780511615061 · Cited by 951
Autism and the pervasive developmental disorders
Volkmar, F. R., & Klin, A. (2012) · doi:10.1093/med/9780199696758.003.0214 · Cited by 931
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812
Self-citationMouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776
Autism and pervasive developmental disorders
Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1046/j.0021-9630.2003.00317.x · Cited by 616
(2007) · PubMed · Cited by 597
Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., Ramanantsoa, N., Gallego, J., Ronnenberg, A., Winter, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711555105 · Cited by 556
Research works printed but not linked: 1
- Roberts, 2007, Rodent Societies. An Ecological and Evolutionary Perspective, 255
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Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Self-citationMalkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662
“In addition to deficits in auditory communication, MIA males exhibit a reduction in female urine-induced scent marking, which was also found in BTBR and Shank1 KO males (Wohr et al., 2011a; 2011b).”
BackgroundMethodIn utero exposure to valproic acid and autism — A current review of clinical and animal studies
Roullet, F., Lai, J., & Foster, J. A. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.01.004 · Cited by 444
Self-citationYang, M., Bozdagi, O., Scattoni, M. L., Wöhr, M., Roullet, F. I., Katz, A. M., Abrams, D. N., Kalikhman, D., Simon, H., Woldeyohannes, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6107-11.2012 · Cited by 369
“One week after the male–female social interaction test, male subjects of the WT-HET group and Cohort 1 were tested for scent marking behaviors and ultrasonic vocalizations in the presence of female urinary pheromones, as previously described (Roullet et al., 2011; Wöhr et al., 2011).”
BackgroundMethodInfluentialSelf-citationScattoni, M. L., Ricceri, L., & Crawley, J. N. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00623.x · Cited by 340
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Metadata
- Authors
- Wöhr, M., Roullet, F. I., & Crawley, J. N.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Wöhr, M.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2010-03-22
- Volume
- 10
- Issue
- 1
- Pages
- 35-43
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC2903641
- OpenAlex
- W2003863298
- Cited by
- 169
- References
- 69
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 6 · 2016: 11 · 2015: 20 · 2014: 16 · 2013: 13 · 2012: 22
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- National Institute of Mental Health (ZIAMH002179)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- BTBR T+tf/J mice, autism spectrum disorder, mouse models of autism, scent marking, ultrasonic vocalizations, social communication deficits, social interaction, C57BL/6J mice, social cues
- MeSH terms
- Animals, Animal Communication, Autistic Disorder, Behavior, Animal, Female, Male, Mice, Inbred C57BL, Mice, Neurologic Mutants, Motor Activity, Odorants, Ultrasonics, Urine, Vocalization, Animal, Mice
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