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ApoE isoform‐dependent deficits in extinction of contextual fear conditioning
Abstract
The three major human apoE isoforms (apoE2, apoE3 and apoE4) are encoded by distinct alleles (ϵ2, ϵ3 and ϵ4). Compared with ϵ3, ϵ4 is associated with increased risk to develop Alzheimer's disease (AD), cognitive impairments in Parkinson's disease (PD), and other conditions. In contrast, a recent study indicated an increased susceptibility to the recurring and re‐experiencing symptom cluster of Post‐Traumatic Stress Disorder (PTSD), as well as related memory impairments, in patients carrying at least one ϵ2 allele. Contextual fear conditioning and extinction are used in human and animal models to study this symptom cluster. In this study, acquisition (day 1, training), consolidation (day 2, first day of re‐exposure) and extinction (days 2–5) of conditioned contextual fear in human apoE2, apoE3 and apoE4 targeted replacement and C57BL/6J wild‐type (WT) mice was investigated. Male and female apoE2 showed acquisition and retrieval of conditioned fear, but failed to exhibit extinction. In contrast, WT, apoE3 and apoE4 mice showed extinction. While apoE2 mice exhibited lower freezing in response to the context on day 2 than apoE3 and apoE4 mice, this cannot explain their extinction deficit as WT mice exhibited similar freezing levels as apoE2 mice on day 2 but still exhibited extinction. Elevating freezing through extended training preserved extinction in controls, but failed to ameliorate extinction deficits in apoE2 animals. These data along with clinical data showing an association of apoE2 with susceptibility to specific symptom clusters in PTSD supports an important role for apoE isoform in the extinction of conditioned fear.
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“APOE genotype has been shown to affect fear conditioning in mice (Kornecook et al., 2010, Olsen et al., 2012).”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Olsen et al., 2012
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Trauma and Posttraumatic Stress Disorder in the Community: The 1996 Detroit Area Survey of Trauma
Breslau, N., Kessler, R. C., Chilcoat, H. D., Schultz, L. R., Davis, G. C., & Andreski, P. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.626 · Cited by 2,407
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575
Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364 · cited 1×
“In contrast, in mice expressing apoE in either neurons or astrocytes, apoE4 mice do show cognitive impairments compared with to apoE3 mice (Hartman et al. 2001; Raber et al. 1998; van Meer et al. 2003).”
BackgroundSelf-citationSledjeski, E. M., Speisman, B., & Dierker, L. C. (2008) · Journal of Behavioral Medicine · doi:10.1007/s10865-008-9158-3 · Cited by 300
Sullivan, P. M., Mezdour, H., Quarfordt, S. H., & Maeda, N. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2673 · Cited by 264 · cited 2×
“Three to six-month-old Targeted Replacement (TR) apoE2 (Sullivan et al. 1998), apoE3 (Sullivan et al. 1997), and apoE4 (Knouff et al. 806 © 2012 The Authors Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society 1999) mice, expressing…”
BackgroundAnxiety disorders and suicidality in the National Comorbidity Survey-Replication
Cougle, J. R., Keough, M. E., Riccardi, C. J., & Sachs-Ericsson, N. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.12.004 · Cited by 253
Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning
Knight, D. C., Smith, C. N., Cheng, D. T., Stein, E. A., & Helmstetter, F. J. (2004) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.4.3.317 · Cited by 249
Hartman, R. E., Wozniak, D. F., Nardi, A., Olney, J. W., Sartorius, L., & Holtzman, D. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7715 · Cited by 157
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Research works printed but not linked: 39
- 10.1002/1098-1063(2001)11:1<8::AID-HIPO1015>3.0.CO;2-7 · DOI
- 10.3389/fnbeh.2010.00158 · DOI · Paper page
- 10.1007/s002210100746 · DOI
- 10.1176/ajp.152.4.529 · DOI
- Cannistraro P.A., 2003, Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies, Psychopharmacol Bull, 37, 8
- 10.1016/S0165-1781(01)00285-2 · DOI · Paper page
- 10.1001/archpsyc.1993.01820160064008 · DOI
- 10.1037/0735-7044.120.5.1187 · DOI · Paper page
- 10.1523/JNEUROSCI.2246-05.2005 · DOI
- 10.1101/lm.204806 · DOI
- Freeman T., 2005, Neuropsychiatric Associations of Apolipoprotein E Alleles in Subjects With Combat‐ Related Posttraumatic Stress Disorder, J Neuropsychiatry Clin Neurosci, 17, 541, 10.1176/jnp.17.4.541 · DOI
- Herry C., 2002, Prefrontal cortex long‐term potentiation, but not long‐term depression, is associated with the maintenance of extinction of learned fear in mice, J Neurosci, 22, 577, 10.1523/JNEUROSCI.22-02-00577.2002 · DOI
- 10.1073/pnas.050004797 · DOI · Paper page
- 10.1212/01.WNL.0000063317.44167.5C · DOI
- 10.1212/01.WNL.0000130159.28215.6A · DOI
- 10.1002/hipo.20331 · DOI · Paper page
- Kessler R.C., 2000, Posttraumatic stress disorder: the burden to the individual and to society, J Clin Psychiatr, 61, 4
- Kessler R.C., 2007, Lifetime prevalence and age‐of‐onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative, World Psychiatr, 6, 168
- 10.1001/archpsyc.1995.03950240066012 · DOI · Paper page
- 10.1172/JCI6172 · DOI · Paper page
- 10.1037/0021-843X.117.2.460 · DOI
- 10.1111/j.1601-183X.2009.00545.x · DOI · Paper page
- 10.1126/science.3283935 · DOI · Paper page
- 10.1146/annurev.neuro.24.1.897 · DOI · Paper page
- 10.1016/0006-8993(94)91176-2 · DOI
- 10.1136/mp.56.3.132 · DOI
- 10.1016/j.bbr.2006.10.024 · DOI
- Pham J., 2009, Automated scoring of fear‐related behavior using EthoVision software, J Neurosci, 178, 323
- 10.1097/01.nmd.0000168263.89652.6b · DOI
- 10.1016/j.neurobiolaging.2010.03.002 · DOI
- 10.1196/annals.1364.025 · DOI
- 10.1111/j.1600-0447.1993.tb03419.x · DOI
- 10.1176/appi.ajp.159.10.1675 · DOI
- 10.1002/ajmg.10249 · DOI
- 10.1097/00001756-200412030-00020 · DOI · Paper page
- 10.1002/hipo.20659 · DOI
- 10.1667/RR0642.1 · DOI
- Villasana L., 2008, Passive avoidance learning and memory of 56Fe sham‐irradiated and irradiated human apoE transgenic mice, Radiat Biol Radioecol, 48, 191
- 10.1002/ajmg.10111 · DOI
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Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 107
Self-citationRaber, J., Arzy, S., Bertolus, J. B., Depue, B., Haas, H. E., Hofmann, S. G., Kangas, M., Kensinger, E., Lowry, C. A., Marusak, H. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.015 · Cited by 62
Self-citationHippocampus-related cognitive impairments in young apoE4 targeted replacement mice
Salomon-Zimri, S., Boehm-Cagan, A., Liraz, O., & Michaelson, D. M. (2013) · Neurodegenerative Diseases · doi:10.1159/000354777 · Cited by 34
Metadata
- Authors
- Olsen, R. H. J., Agam, M., Davis, M. J., & Raber, J.
- Affiliations
- Division of Neuroscience Oregon National Primate Research Portland OR USA
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2012-09-07
- Volume
- 11
- Issue
- 7
- Pages
- 806-812
- ISSN
- 1601-1848
- 1601-183X
- PMC
- PMC3642038
- Cited by
- 35
- References
- 9
- Language
- en
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