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Cited by 119Posttraumatic Stress Disorder ResearchChild Abuse and TraumaPsychoanalysis and Psychopathology Research

Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study

Richert, Katherine A., Carrion, Victor G., Karchemskiy, Asya, Reiss, Allan L.·2006·Depression and Anxiety
DOI 10.1002/da.20131
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Abstract

Previous studies have revealed altered structural development of the frontal lobes and prefrontal cortex (PFC) in children with symptoms of posttraumatic stress disorder (PTSD). This study is the first to provide a detailed structural analysis of the PFC in children with and without PTSD symptoms. We compared gray and white matter volume in four subregions of the PFC between said groups, then explored whether volume was associated with PTSD symptom severity and functional impairment. PFC measurements were extracted from magnetic resonance imaging (MRI) data from a sample of 23 children (ages 7-14) with a history of trauma and symptoms of PTSD, who had undergone assessment for PTSD symptoms and functional impairment using the Child and Adolescent version of the Clinician-Administered PTSD Scale (CAPS-CA). These measurements were compared to data from an age-equivalent control group of 24 healthy children. Children with PTSD symptoms showed a significantly larger volume of gray matter in the delineated middle-inferior and ventral regions of the PFC than did control children. Decreased volume of gray matter in the dorsal PFC correlated with increased functional impairment scores. Results indicate that increased volume of the middle-inferior and ventral PFC may be associated with trauma and PTSD symptoms in children. Furthermore, the neuroanatomy of the dorsal PFC may influence the degree of functional impairment experienced by children with PTSD symptoms.

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  • After controlling for total gray matter volume, children who experienced trauma had larger middle-inferior and ventral PFC volume than comparison youth.

    “After controlling for total gray matter volume, children who experienced trauma had larger middle-inferior and ventral PFC volume than comparison youth (Richert et al, 2006).”

    From Deviations from the expectable environment in early childhood and emerging psychopathology (2015) · cites this paper as Richert et al, 2006

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Authors
Richert, K. A., Carrion, V. G., Karchemskiy, A., & Reiss, A. L.
Affiliations
Stanford Medicine (US)
ORCID
Reiss, Allan L.
Venue
Depression and Anxiety
Publisher
Hindawi Limited
Published
2006
Volume
23
Issue
1
Pages
17-25
ISSN
  • 1091-4269 (ISSN-L)
  • 1520-6394
DOI
10.1002/da.20131
OpenAlex
W2054862365
Cited by
118
References
47
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 11 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 10
FWCI
2.70
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1 (tdm, 3530 d)
Locations
  • Depression and Anxiety (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH63803, MH01142, K02MH001142)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
prefrontal cortex, gray matter volume, white matter volume, dorsal prefrontal cortex, ventral prefrontal cortex, functional disability, trauma exposure, structural brain development
MeSH terms
Adolescent, Electronic Data Processing, Child, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Surveys and Questionnaires, Severity of Illness Index, Software, Stress Disorders, Post-Traumatic, Prefrontal Cortex

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