Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder
Open accessAbstract
Background To examine neuroanatomical morphometry in adult female victims of intimate partner violence with and without posttraumatic stress disorder. Methods Seventeen nonvictimized comparison subjects and 22 victims of intimate partner violence, 11 with and 11 without posttraumatic stress disorder, were studied. Using quantitative magnetic resonance imaging, three mesial temporal lobe areas were measured: hippocampus, amygdala, and parahippocampal gyrus. Additionally, whole brain morphometry provided fluid, gray, and white matter volumes of the cortex and cerebellum for exploratory analyses. Relationships of morphometric measures to symptoms, abuse history, and neuropsychological function were examined. Results Intimate partner violence subjects with posttraumatic stress disorder did not demonstrate significantly smaller hippocampal or other mesial temporal lobe volumes. Overall, intimate partner violence subjects had smaller supratentorial cranial vaults and smaller frontal and occipital gray matter volumes relative to nonvictimized comparison subjects. Supratentorial cranial vault volume was negatively correlated with severity of childhood physical abuse, but not with intimate partner violence or posttraumatic stress disorder severity. Trails B performance was negatively correlated with frontal gray matter volume. Conclusions These findings are inconsistent with prior reports of smaller hippocampal volumes in patients with posttraumatic stress disorder. Rather, the findings point to cerebral abnormalities that may reflect the influence of early trauma on neurodevelopmental processes or denote brain morphometric characteristics of persons at increased risk for serious psychosocial adversity.
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Other studies, including one meta-analysis, failed to identify amygdala volumetric abnormalities associated with PTSD.
“Other studies including one meta-analysis failed to identify amygdala volumetric abnormalities associated with PTSD (Fennema-Notestine et al., 2002;Herringa et al., 2012;Sui et al., 2010).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Fennema-Notestine et al., 2002
Several morphometric MRI studies have reported decreased volumes of frontal cortex in PTSD.
“Several morphometric MRI studies have reported decreased volumes of frontal cortex in PTSD (Carrion et al., 2001;Fennema-Notestine et al., 2002).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Fennema-Notestine et al., 2002
PTSD is associated with decreased volumes of frontal cortex.
“Decreased volumes of frontal cortex fMRI: Carrion et al. (2001); Fennema-Notestine et al. (2002)”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Fennema-Notestine et al. (2002)
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- Authors
- Fennema-Notestine, C., Stein, M. B., Kennedy, C. M., Archibald, S. L., & Jernigan, T. L.
- Affiliations
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- Corresponding author
- Stein, Murray B
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 52
- Issue
- 11
- Pages
- 1089-1101
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2097662492
- Cited by
- 274
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 11 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 13 · 2016: 19 · 2015: 15 · 2014: 13 · 2013: 13 · 2012: 14
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.escholarship.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Social Sciences › Health › Intimate Partner and Family Violence
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- intimate partner violence, post-traumatic stress disorder, brain morphometry, hippocampus, amygdala, parahippocampal gyrus, medial temporal lobe, gray matter volume, white matter volume, child physical abuse, frontal lobe, neuropsychological performance, women
- MeSH terms
- Adult, Brain, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Middle Aged, Surveys and Questionnaires, Stress Disorders, Post-Traumatic, Temporal Lobe, Case-Control Studies, Domestic Violence, Crime Victims
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