Cited by 1,882Statistical Methods in EpidemiologyMeta-analysis and systematic reviewsClinical Laboratory Practices and Quality Control

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Understanding diagnostic tests 3: receiver operating characteristic curves

Akobeng, Anthony K·2007·Acta Paediatrica

DOI 10.1111/j.1651-2227.2006.00178.x

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Abstract

The results of many clinical tests are quantitative and are provided on a continuous scale. To help decide the presence or absence of disease, a cut‐off point for ‘normal’ or ‘abnormal’ is chosen. The sensitivity and specificity of a test vary according to the level that is chosen as the cut‐off point. The receiver operating characteristic (ROC) curve, a graphical technique for describing and comparing the accuracy of diagnostic tests, is obtained by plotting the sensitivity of a test on the y axis against 1‐specificity on the x axis. Two methods commonly used to establish the optimal cut‐off point include the point on the ROC curve closest to (0, 1) and the Youden index. The area under the ROC curve provides a measure of the overall performance of a diagnostic test. In this paper, the author explains how the ROC curve can be used to select optimal cut‐off points for a test result, to assess the diagnostic accuracy of a test, and to compare the usefulness of tests. Conclusion: The ROC curve is obtained by calculating the sensitivity and specificity of a test at every possible cut‐off point, and plotting sensitivity against 1‐specificity. The curve may be used to select optimal cut‐off values for a test result, to assess the diagnostic accuracy of a test, and to compare the usefulness of different tests.

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Authors: Akobeng, A. K.
Corresponding author: Akobeng, Anthony K
ORCID: Akobeng, Anthony K
Venue: Acta Paediatrica
Publisher: Wiley
Published: 2007-03-21
Volume: 96
Issue: 5
Pages: 644-647
ISSN: 0365-1436 (ISSN-L)
0803-5253
1651-2227
DOI: 10.1111/j.1651-2227.2006.00178.x
OpenAlex: W2073887351
Cited by: 1,882
References: 17
Citations by year: 2026: 53 · 2025: 95 · 2024: 135 · 2023: 138 · 2022: 167 · 2021: 156 · 2020: 131 · 2019: 116 · 2018: 102 · 2017: 120 · 2016: 113 · 2015: 117 · 2014: 117 · 2013: 98 · 2012: 76
FWCI: 29.05
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Paediatrica (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Keywords: receiver operating characteristic, diagnostic accuracy, cut-point selection, sensitivity, specificity, Youden index, area under the ROC curve, diagnostic test comparison
MeSH terms: C-Reactive Protein, Calcitonin, Humans, Leukocyte Count, Protein Precursors, ROC Curve, Sensitivity and Specificity, Shock, Septic

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Understanding diagnostic tests 3: receiver operating characteristic curves

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