CoChat
Sign Up
Cited by 140Calcium signaling and nucleotide metabolismAdenosine and Purinergic SignalingBiochemical and Molecular Research

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)

Guse, Andreas H.·2005·The FEBS Journal
DOI 10.1111/j.1742-4658.2005.04863.x
Open this paper in CoChat — free account

Abstract

Cyclic ADP-ribose (cADPR) is a Ca2+ mobilizing second messenger found in various cell types, tissues and organisms. Receptor-mediated formation of cADPR may proceed via transmembrane shuttling of the substrate NAD and involvement of the ectoenzyme CD38, or via so far unidentified ADP-ribosyl cyclases located within the cytosol or in internal membranes. cADPR activates intracellular Ca2+ release via type 2 and 3 ryanodine receptors. The exact molecular mechanism, however, remains to be elucidated. Possibilities are the direct binding of cADPR to the ryanodine receptor or binding via a separate cADPR binding protein. In addition to Ca2+ release, cADPR also evokes Ca2+ entry. The underlying mechanism(s) may comprise activation of capacitative Ca2+ entry and/or activation of the cation channel TRPM2 in conjunction with adenosine diphosphoribose. The development of novel cADPR analogues revealed new insights into the structure-activity relationship. Substitution of either the northern ribose or both the northern and southern ribose resulted in much simpler molecules, which still retained significant biological activity.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1742-4658.2005.04863.x

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 64 references

Cited by

Sorted by citations

See all 140

Related

Metadata

Authors
Guse, A. H.
Affiliations
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author
Guse, Andreas H.
ORCID
Guse, Andreas H.
Venue
The FEBS Journal
Publisher
Wiley
Published
2005-08-26
Volume
272
Issue
18
Pages
4590-4597
ISSN
  • 1742-464X (ISSN-L)
  • 1742-4658
DOI
10.1111/j.1742-4658.2005.04863.x
OpenAlex
W1969246107
Cited by
139
References
64
Citations by year
2025: 1 · 2024: 1 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 7
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • FEBS Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords
cyclic ADP-ribose, second messengers, calcium mobilization, ryanodine receptor, CD38, ADP-ribosyl cyclase, NAD+, structure-activity relationship, TRPM2, store-operated calcium entry, intracellular calcium release, cation channels
MeSH terms
Animals, Calcium, Glycoproteins, Humans, Structure-Activity Relationship, Second Messenger Systems, Molecular Chaperones, Ryanodine Receptor Calcium Release Channel, Calcium Signaling, Cyclic ADP-Ribose, Clusterin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review