Cited by 140Calcium signaling and nucleotide metabolismAdenosine and Purinergic SignalingBiochemical and Molecular Research

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Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)

Guse, Andreas H.·2005·The FEBS Journal

DOI 10.1111/j.1742-4658.2005.04863.x

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Abstract

Cyclic ADP-ribose (cADPR) is a Ca2+ mobilizing second messenger found in various cell types, tissues and organisms. Receptor-mediated formation of cADPR may proceed via transmembrane shuttling of the substrate NAD and involvement of the ectoenzyme CD38, or via so far unidentified ADP-ribosyl cyclases located within the cytosol or in internal membranes. cADPR activates intracellular Ca2+ release via type 2 and 3 ryanodine receptors. The exact molecular mechanism, however, remains to be elucidated. Possibilities are the direct binding of cADPR to the ryanodine receptor or binding via a separate cADPR binding protein. In addition to Ca2+ release, cADPR also evokes Ca2+ entry. The underlying mechanism(s) may comprise activation of capacitative Ca2+ entry and/or activation of the cation channel TRPM2 in conjunction with adenosine diphosphoribose. The development of novel cADPR analogues revealed new insights into the structure-activity relationship. Substitution of either the northern ribose or both the northern and southern ribose resulted in much simpler molecules, which still retained significant biological activity.

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A model for receptor-regulated calcium entry
Putney, J. W. (1986) · Cell Calcium · doi:10.1016/0143-4160(86)90026-6 · Cited by 2,575
Depletion of intracellular calcium stores activates a calcium current in mast cells
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ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
Perraud, A., Fleig, A., Dunn, C., Bagley, L. A., Launay, P., Schmitz, C., Stokes, A. J., Zhu, Q., Bessman, M. J., Penner, R., et al. (2001) · Nature · doi:10.1038/35079100 · Cited by 895
Ca 2+ -Induced Ca 2+ Release in Sea Urchin Egg Homogenates: Modulation by Cyclic ADP-Ribose
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Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.
Clapper, D. L., Walseth, T. F., Dargie, P. J., & Lee, H. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47970-7 · Cited by 568
Mechanisms of capacitative calcium entry
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Authors: Guse, A. H.
Affiliations: University Medical Center Hamburg-Eppendorf (DE)
Corresponding author: Guse, Andreas H.
ORCID: Guse, Andreas H.
Venue: The FEBS Journal
Publisher: Wiley
Published: 2005-08-26
Volume: 272
Issue: 18
Pages: 4590-4597
ISSN: 1742-464X (ISSN-L)
1742-4658
DOI: 10.1111/j.1742-4658.2005.04863.x
OpenAlex: W1969246107
Cited by: 139
References: 64
Citations by year: 2025: 1 · 2024: 1 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 7
FWCI: 1.50
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Journal (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: cyclic ADP-ribose, second messengers, calcium mobilization, ryanodine receptor, CD38, ADP-ribosyl cyclase, NAD+, structure-activity relationship, TRPM2, store-operated calcium entry, intracellular calcium release, cation channels
MeSH terms: Animals, Calcium, Glycoproteins, Humans, Structure-Activity Relationship, Second Messenger Systems, Molecular Chaperones, Ryanodine Receptor Calcium Release Channel, Calcium Signaling, Cyclic ADP-Ribose, Clusterin

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Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)

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