The DOI matches its Crossref record; 158 of the 159 references it cites were found in a registry or an index.
Vitamin C. Biosynthesis, recycling and degradation in mammals
Open accessAbstract
Vitamin C, a reducing agent and antioxidant, is a cofactor in reactions catalyzed by Cu(+)-dependent monooxygenases and Fe(2+)-dependent dioxygenases. It is synthesized, in vertebrates having this capacity, from d-glucuronate. The latter is formed through direct hydrolysis of uridine diphosphate (UDP)-glucuronate by enzyme(s) bound to the endoplasmic reticulum membrane, sharing many properties with, and most likely identical to, UDP-glucuronosyltransferases. Non-glucuronidable xenobiotics (aminopyrine, metyrapone, chloretone and others) stimulate the enzymatic hydrolysis of UDP-glucuronate, accounting for their effect to increase vitamin C formation in vivo. Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily. l-Gulonate is converted to l-gulonolactone by a lactonase identified as SMP30 or regucalcin, whose absence in mice leads to vitamin C deficiency. The last step in the pathway of vitamin C synthesis is the oxidation of l-gulonolactone to l-ascorbic acid by l-gulonolactone oxidase, an enzyme associated with the endoplasmic reticulum membrane and deficient in man, guinea pig and other species due to mutations in its gene. Another fate of glucuronate is its conversion to d-xylulose in a five-step pathway, the pentose pathway, involving identified oxidoreductases and an unknown decarboxylase. Semidehydroascorbate, a major oxidation product of vitamin C, is reconverted to ascorbate in the cytosol by cytochrome b(5) reductase and thioredoxin reductase in reactions involving NADH and NADPH, respectively. Transmembrane electron transfer systems using ascorbate or NADH as electron donors serve to reduce semidehydroascorbate present in neuroendocrine secretory vesicles and in the extracellular medium. Dehydroascorbate, the fully oxidized form of vitamin C, is reduced spontaneously by glutathione, as well as enzymatically in reactions using glutathione or NADPH. The degradation of vitamin C in mammals is initiated by the hydrolysis of dehydroascorbate to 2,3-diketo-l-gulonate, which is spontaneously degraded to oxalate, CO(2) and l-erythrulose. This is at variance with bacteria such as Escherichia coli, which have enzymatic degradation pathways for ascorbate and probably also dehydroascorbate.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“So far, the synthesis of vitamin C was documented in all plant species, including algae and photosynthetic protists [1].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“They are, therefore, fully dependent on vitamin C intake from the diet [1,2,3].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“In contrast to most of the vertebrates, guinea pigs, bats, passeriform birds, and primates, including humans, lack L-gulono-1,4-lactone oxidase, and, hence, cannot synthesize vitamin C.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“The pKa of ascorbic acid is 4.1–4.2. Hence, it is present completely as a monoanion—ascorbate at the physiological pH [1,2,4,68].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“2,3-diketo-1-gulonic acid can be spontaneously, but also enzymatically, decomposed to erythrulose and oxalate. This reaction is accelerated by bicarbonate [1,3].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“There are apparently redundant pathways mediating the reduction of dehydroascorbic acid to ascorbic acid. They include both direct but slow nonenzymatic reduction by glutathione and enzymatic by a couple of enzymes (e.g., glutaredoxin, glutathione transferase omega 2, or thioredoxin reductase). Of note is that the first two enzymes require glutathione for their activity [1,73].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
Citations
Cites
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
The metabolic and molecular bases of inherited disease
Chen, Y.-T. (2001) · Medical Entomology and Zoology · Cited by 6,928
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
Emanuelsson, O., Nielsen, H., Brunak, S., & von Heijne, G. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3903 · Cited by 4,419
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid
Buettner, G. R., & Jurkiewicz, B. A. (1996) · Radiation Research · doi:10.2307/3579271 · Cited by 900
Glutathione-ascorbic acid antioxidant system in animals
Meister, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36891-6 · Cited by 812
Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases
Philip G. Board, Coggan, M., Chelvanayagam, G., Easteal, S., Jermiin, L. S., Schulte, G. K., Danley, D. E., Hoth, L. R., Griffor, M. C., Kamath, A. V., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001706200 · Cited by 736
The biochemical functions of ascorbic acid
Englard, S., & Seifter, S. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.002053 · Cited by 564
Nishikimi, M., Fukuyama, R., Minoshima, S., Shimizu, N., & Yagi, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36884-9 · Cited by 505
Research works printed but not linked: 1
- Moreau R, 1998, Fish acquired ascorbic acid synthesis prior to terrestrial vertebrate emergence, Free Radic Biol Med, 25, 989
Cited by
Sorted by citations
Items 701–792 of 792
Harmful Effects of Antioxidant Therapy
Stewart, A. F., & Kim, E. D. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9158-3_27
A Study on the Wound Healing Properties of Medicago sativa
Sharma, P., Das, S., & Mohanta, T. (2021) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v11i4.4940
Haase, I., Fischer, M. J., Bacher, A., Eisenreich, W., & Rohdich, F. (2008) · Wiley eBooks · doi:10.1002/9780470048672.wecb094
Ascorbic Acid Therapy in Hematological Malignancies - The Current Knowledge and Future DirectionsPreprint
Lam, W. K., Ha, C. Y., & Yip, S. F. (2022) · doi:10.32388/pmlz1t.5
Jadhav, R. A., Joshi, A. S., Pawar, P. R., Ahirrao, V. K., & Bembalkar, S. R. (2022) · Asian Journal of Chemistry · doi:10.14233/ajchem.2022.23803
Kommentar zu „Intravenöse Vitamin C-Gabe: 28-Tage-Ergebnis septischer Patienten verschlechtert?“
(2022) · Aktuelle Ernährungsmedizin · doi:10.1055/a-1923-7798
Vitamin C and Vitamin D: Safe enough in liver with iron overload?Preprint
Güvendi, G. F. (2023) · Research Square · doi:10.21203/rs.3.rs-2941503/v1
Recent Advances in Research on Vitamin C Transporters
Toyoda, Y., Miyata, H., & Takada, T. (2023) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.76.193
Ex vivo lipid peroxidation profile of the subjects stratum corneum by the HPLC-TBARS-EVSC protocol
Marques, G. D. A. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.9.2023.tde-18082023-151307
Consideration of the Synergy of Vitamins E and C in the Kinetic Model of Lipid Peroxidation
Kanarovskii, E. Y., & Yaltychenko, O. V. (2023) · Surface Engineering and Applied Electrochemistry · doi:10.3103/s1068375523040038
Synergy Effect of Ascorbic Acid and α-Tocopherol in Kinetic Model of Lipid Peroxidation
Kanarovskii, E. Y., & Yaltychenko, O. V. (2023) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-031-42782-4_35
Antioxidants as Adjuncts to Conventional Therapies Against Oxidative Stress
Ahmed, A., Saleem, M. A., Afzaal, M., Ali, S. W., Nadeem, M., & Majeed, N. (2023) · Food bioactive ingredients · doi:10.1007/978-3-031-41188-5_9
Exploring the Potential Impact of Herbal Antioxidants on Human Cardiovascular Diseases
Marak, W. (2023) · Sciences of Phytochemistry · doi:10.58920/sciphy02020070 · Cited by 1
Redox Regulation in Hematology and Stem Cell Research
Mushtaq, I., Hussain, K., Ishtiaq, A., & Murtaza, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00114-1
Nigella Sativa’nın (çörek otu) sağlık üzerine etkisi
Aygün, S. B., & Karataş, E. (2024) · Toros University Journal of Food Nutrition and Gastronomy · doi:10.58625/jfng-2477
AlOgaidi, A. J. M., Easa, H. A., Hassan, S. S., AlOqaili, F., & Jassim, L. S. (2024) · Journal of Angiotherapy · doi:10.25163/angiotherapy.849579
The Story of Vitamin C and its Versions in Sepsis and COVID-19: Traditional Review
HEMDAN, O. A. M., Sanajou, S., & Baydar, T. (2024) · Journal of Literature Pharmacy Sciences · doi:10.5336/pharmsci.2024-101309
Management of Male Oxidative Stress Infertility (MOSI)
Ko, E., & Karthikeyan, V. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-62648-7_7
Omics-Based Approaches in Stroke Research
(2024) · Frontiers research topics · doi:10.3389/978-2-8325-5355-8
THE INVOLVEMENT OF DIFFERENT VITAMIN TYPES IN ASSISTING THE ACTIVATION OF STEM CELLS: A REVIEW
Hapsari, T. P. (2024) · Journal of Stem Cell Research and Tissue Engineering · doi:10.20473/jscrte.v8i1.57473
VITAMIN C: STRUCTURE, BIOCHEMICAL SIGNIFICANCE, METHODS OF DETERMINATION
Moroz, I., Shemet, V. Y., & Гулай, О. І. (2024) · Proceedings of the Shevchenko Scientific Society Series Сhemical sciences · doi:10.37827/ntsh.chem.2024.75.078
Learning genotype–phenotype associations from gaps in multi-species sequence alignments
Islam, U. I., dos Santos, A. L. C., Kanjilal, R., & Assis, R. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf022
Каманова, С. Г., Shaimenova, B., Murat, L., Садуахасова, С. А., Khamitova, D., Muratkhan, M., Tarabayev, B., & Ospankulova, G. (2025) · Foods · doi:10.3390/foods14091469
Sensing the Concentration of Biological Reductants through Single-Molecule Fluorescence Blinking
Kondo, Y., Tsuchitori, S., Yonezawa, Y., Takada, T., Maruyama, A., Fujitsuka, M., & Kawai, K. (2025) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.5c00475
Blueprint of the distinct metabolite profiles of healthy pig heart chambers
Haikonen, R., Meuronen, T., Koistinen, V., Kärkkäinen, O. K., Tuomainen, T., Solano-Aguilar, G. I., Urban, J. F., Lehtonen, M., Tavi, P., & Hanhineva, K. (2025) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2025.100462
Oxidative Stress Factors is Effective on Reproductive Functions: A Review
Gözüyukarı, H., & Kılıç, S. H. (2025) · Anatolian journal of obstetrics and gynecology research. · doi:10.4274/anajog.galenos.2025.83997
Turčić, M., & Pavelić, S. K. (2025) · Science, Art and Religion. · doi:10.5005/jp-journals-11005-0108
ВИТАМИН С В МОДУЛЯЦИИ СТАРЕНИЯ КОЖИ: МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ И ИННОВАЦИОННЫЕ СТРАТЕГИИ ДОСТАВКИ
Mikhaylova, N. P., Знатдинов, Д. И., Borzova, I. V., & Selyanin, M. A. (2025) · Успехи геронтологии · doi:10.34922/ae.2025.38.3.015
Bayerl, T., Huber, V. R., Riepl, H., & Urmann, C. (2025) · Phytochemistry Letters · doi:10.1016/j.phytol.2025.104058
225Chapter 13 The Role of Artificial Intelligence in Developing Halal Cosmetic
Tobing, F., Pulungan, J. H., Lestari, Y. A., Santri, D., & Syahrial, H. (2025) · De Gruyter eBooks · doi:10.1515/9783111575407-014
A REVIEW ON ANTIOXIDANT VITAMIN C AND ITS IMPACT ON SKIN HEALTH
Behera, P., Sharma, A., BISWAL, S., MOHARANA, S., Biswal, P. K., & Panda, B. B. (2025) · Innovare Journal of Medical Sciences · doi:10.22159/ijms.2025v13i5.55899
Measurement of glutathione synthesis by isotope ratio mass spectrometry in systemic inflammation
Kimura, Y. (2010) · UCL Discovery (University College London)
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.25807458
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719536
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719488
Liang, L., He, M., Zhang, Y., Wang, C., Qin, Z., Li, Q., Yang, T., Meng, F., Zhou, Y., Ge, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24709051
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719497
Liang, L., He, M., Zhang, Y., Wang, C., Qin, Z., Li, Q., Yang, T., Meng, F., Zhou, Y., Ge, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26647374
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719515
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719500
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719527
Krupenko, N. I., Sharma, J., Pediaditakis, P., Helke, K. L., Hall, M. S., Du, X., Sumner, S., & Krupenko, S. A. (2020) · Figshare · doi:10.6084/m9.figshare.13212581
Liang, L., He, M., Zhang, Y., Wang, C., Qin, Z., Li, Q., Yang, T., Meng, F., Zhou, Y., Ge, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26647368
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719533
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719503
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719512
Krupenko, N. I., Sharma, J., Pediaditakis, P., Helke, K. L., Hall, M. S., Du, X., Sumner, S., & Krupenko, S. A. (2020) · Figshare · doi:10.6084/m9.figshare.13212557
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719509
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719524
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719539
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719530
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719521
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719491
Liang, L., He, M., Zhang, Y., Wang, C., Qin, Z., Li, Q., Yang, T., Meng, F., Zhou, Y., Ge, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24709096
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719506
Liang, L., He, M., Zhang, Y., Wang, C., Qin, Z., Li, Q., Yang, T., Meng, F., Zhou, Y., Ge, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26647371
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719494
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.26719518
Aumailley, L., Bodein, A., Adjibade, P., Leclercq, M., Bourassa, S., Droit, A., Mazrouï, R., & Lebel, M. (2024) · Figshare · doi:10.6084/m9.figshare.25807389
Jiang, C.-L., Tsao, C.-Y., & Lee, Y.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20329735
Halal Meat, Fat, Oil, and Cosmetics Authentication
Mahesar, S. A., Shah, S. T. H., Ramadan, M. F., & Panhwar, W. N. (2025) · SpringerBriefs in food, health and nutrition · doi:10.1007/978-3-031-92773-7_5
Ünal, C. N., & Uzti̇mür, M. (2025) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3747.c357
Singh, A. K., Ojha, B. K., Rajoriya, J. S., & Jha, A. K. (2025) · Indian Journal of Animal Health · doi:10.36062/ijah.2025.spl.02425
Wilson, R. B., Liang, Y., Kaushal, D., & Carr, A. C. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf230
The Synergistic Role of Gut Microbiota and Antioxidant Vitamins in Human Health
Sandeep, I. S., Pasham, S., Boini, K. M., & Koka, S. (2026) · Advances in biochemistry in health and disease · doi:10.1007/978-3-032-14441-6_17
Muthike, C. W. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33433-7.00010-1
Nam, K. C., Park, W., Sun, H. J., & Park, B. J. (2026) · Molecules · doi:10.3390/molecules31040732
Alterations of Plasma Metabolites Associated with Sickle Cell Trait
Cai, Y., Surapaneni, A., Vasconcelos, A. G., Johnson, M., Hsu, L., Sun, W., Kooperberg, C. L., Yu, B., Yeo, W.-J., Auer, P. L., et al. (2026) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000001015
Спектр применения фитовитаминного комплекса в терапии обильных маточных кровотечений
Николаевна, Г. Е. (2026) · Репродуктивное здоровье Восточная Европа · doi:10.34883/pi.2026.16.1.009
Insight into the metabolism of gliomas by MRI and MRS
Pandey, S., Yadav, N., Tiwari, V., & Jagannathan, N. R. (2026) · Biophysical Reviews · doi:10.1007/s12551-026-01416-z
Ngadin, A. A. (2011) · theses.fr (ABES) · doi:10.70675/dd23d0b8zcc4ez4867zac9ez30a36b52fa57
グルタチオンの皮膚環境改善作用とその肝機能に与える分子制御機構の解明
Yoshiaki, U., ヨシアキ, ウ., & YOSHIAKI, U. (2025) · Institutional Repositories DataBase (IRDB)
Molecular insight into ion transport for calcification in symbiotic and non-symbiotic corals
Capasso, L. (2021) · theses.fr (ABES) · doi:10.70675/341d37d1z90c5z4da7z8f7az77049c4699f4
ward, R., Krishnan, S. S., Stavrovskaya, I. G., Sanchez-Gonzalez, D., Agudelo, C. W., Park, S. S., Mai, M., Cai, H., Martinez, J., Cox, K., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101042
Potential Therapy for Long COVID and Post-vaccination Syndrome
Turčić, M., Pavelić, S. K., & Pavelić, K. (2026) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-032-06531-5_41
Zhao, X., Zhang, T., Qi, Y., Liu, X., Ren, X., Chen, S., Meng, Z., Lin, W., Yang, S., Wang, L., et al. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-24738-5.00078-1
Maternal Dyslipidaemia Aggravates Offspring Metabolic Dysfunction–Associated Steatotic Liver Disease
Pedersen, K., Buhl, S. F., Højgaard‐Jensen, C., Lykkesfeldt, J., & Tveden‐Nyborg, P. (2026) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70235
Parab, A., Dawda, H., & Mukundan, U. (2025) · The Journal of Indian Botanical Society · doi:10.61289/jibs2025.03.18.0359
Singh, K. K., Singh, P., Rajput, H., Kumar, S., & Gupta, A. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.28s.114
de Jong, T. M. H., Slot, D. E., Valkenburg, C., Loos, B. G., & van der Weijden, G. A. (2026) · Journal of Periodontology · doi:10.1002/jper.70142
Orphan Enzymes in the Mammalian L-Fucose Degradation Pathway
Witecka, A., Kaminska, J., Ślusarczyk, K., Piętka, J. J., Witczak, M., Kwiatkowski, S., & Drożak, J. (2026) · Biomolecules · doi:10.3390/biom16070985
ASCORBIC ACID IN AGRO-WASTE: INSIGHTSINTOITSCHEMISTRY, BIOSYNTHESIS AND EXTRACTIONAPPROACHES
Devasundar, E. J., Edayadulla, N., & ShanmugaSundari, C. (2026) · RASAYAN Journal of Chemistry · doi:10.31788/rjc.2026.1939766
Marine-based vitamins and future potentials
Medagoda, N., & Wijemanna, B. U. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29190-6.00014-3
Vitamin C Content in Fresh and Frozen Berries
Soto, A., & Ziaei, S. (2026) · Nutrition And Food In Health And Disease · doi:10.66224/nfsr.13.1.39
Sun, H., Zhou, L., Luo, T., Li, C., Ma, R., Xiong, H., Zhang, J., & Yang, M.-M. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.11.51
Carr, A. C., & Gupta, S. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.09.009
Oñate, G., Salgado, P., Guzmán, P. A., Muñoz, A., Alarcon-Navarro, C., Arriagada, S. P., Moraga‐Cid, G., Muñoz-Montesino, C., Gatica, M., & Rivas, C. I. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1924584
A Safety Evaluation of D-Glucuronolactone Derived from Inositol
Zheng, W., Chen, Q., & Wang, Y. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116477
Metadata
- Authors
- Linster, C. L., & Van Schaftingen, E.
- Affiliations
- de Duve Institute (BE)
- ORCID
- Linster, Carole L.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2006-12-06
- Volume
- 274
- Issue
- 1
- Pages
- 1-22
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2065016714
- Cited by
- 757
- References
- 159
- Citations by year
- 2026: 20 · 2025: 42 · 2024: 66 · 2023: 46 · 2022: 49 · 2021: 61 · 2020: 65 · 2019: 36 · 2018: 26 · 2017: 31 · 2016: 34 · 2015: 31 · 2014: 38 · 2013: 44 · 2012: 37
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- green
- orbilu.uni.lu
- Licence
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- vitamin C, ascorbic acid biosynthesis, UDP-glucuronate, UDP-glucuronosyltransferase, aldehyde reductase, aldo-keto reductase superfamily, L-gulonolactone oxidase, SMP30, regucalcin, dehydroascorbic acid, glutathione, vitamin C degradation, scurvy
- MeSH terms
- Animals, Ascorbic Acid, Carbohydrate Dehydrogenases, Escherichia coli, Glucuronates, Humans, Hydrolysis, Mammals, Models, Biological, Pentose Phosphate Pathway, Uridine Diphosphate Glucuronic Acid, L-Gulonolactone Oxidase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
