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Vitamin C. Biosynthesis, recycling and degradation in mammals
Open accessAbstract
Vitamin C, a reducing agent and antioxidant, is a cofactor in reactions catalyzed by Cu(+)-dependent monooxygenases and Fe(2+)-dependent dioxygenases. It is synthesized, in vertebrates having this capacity, from d-glucuronate. The latter is formed through direct hydrolysis of uridine diphosphate (UDP)-glucuronate by enzyme(s) bound to the endoplasmic reticulum membrane, sharing many properties with, and most likely identical to, UDP-glucuronosyltransferases. Non-glucuronidable xenobiotics (aminopyrine, metyrapone, chloretone and others) stimulate the enzymatic hydrolysis of UDP-glucuronate, accounting for their effect to increase vitamin C formation in vivo. Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily. l-Gulonate is converted to l-gulonolactone by a lactonase identified as SMP30 or regucalcin, whose absence in mice leads to vitamin C deficiency. The last step in the pathway of vitamin C synthesis is the oxidation of l-gulonolactone to l-ascorbic acid by l-gulonolactone oxidase, an enzyme associated with the endoplasmic reticulum membrane and deficient in man, guinea pig and other species due to mutations in its gene. Another fate of glucuronate is its conversion to d-xylulose in a five-step pathway, the pentose pathway, involving identified oxidoreductases and an unknown decarboxylase. Semidehydroascorbate, a major oxidation product of vitamin C, is reconverted to ascorbate in the cytosol by cytochrome b(5) reductase and thioredoxin reductase in reactions involving NADH and NADPH, respectively. Transmembrane electron transfer systems using ascorbate or NADH as electron donors serve to reduce semidehydroascorbate present in neuroendocrine secretory vesicles and in the extracellular medium. Dehydroascorbate, the fully oxidized form of vitamin C, is reduced spontaneously by glutathione, as well as enzymatically in reactions using glutathione or NADPH. The degradation of vitamin C in mammals is initiated by the hydrolysis of dehydroascorbate to 2,3-diketo-l-gulonate, which is spontaneously degraded to oxalate, CO(2) and l-erythrulose. This is at variance with bacteria such as Escherichia coli, which have enzymatic degradation pathways for ascorbate and probably also dehydroascorbate.
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In the citing paper
“So far, the synthesis of vitamin C was documented in all plant species, including algae and photosynthetic protists [1].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“They are, therefore, fully dependent on vitamin C intake from the diet [1,2,3].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“In contrast to most of the vertebrates, guinea pigs, bats, passeriform birds, and primates, including humans, lack L-gulono-1,4-lactone oxidase, and, hence, cannot synthesize vitamin C.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“The pKa of ascorbic acid is 4.1–4.2. Hence, it is present completely as a monoanion—ascorbate at the physiological pH [1,2,4,68].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“2,3-diketo-1-gulonic acid can be spontaneously, but also enzymatically, decomposed to erythrulose and oxalate. This reaction is accelerated by bicarbonate [1,3].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
In the citing paper
“There are apparently redundant pathways mediating the reduction of dehydroascorbic acid to ascorbic acid. They include both direct but slow nonenzymatic reduction by glutathione and enzymatic by a couple of enzymes (e.g., glutaredoxin, glutathione transferase omega 2, or thioredoxin reductase). Of note is that the first two enzymes require glutathione for their activity [1,73].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [1]
Citations
Cites
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
The metabolic and molecular bases of inherited disease
Chen, Y.-T. (2001) · Medical Entomology and Zoology · Cited by 6,928
Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
Emanuelsson, O., Nielsen, H., Brunak, S., & von Heijne, G. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3903 · Cited by 4,419
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid
Buettner, G. R., & Jurkiewicz, B. A. (1996) · Radiation Research · doi:10.2307/3579271 · Cited by 900
Glutathione-ascorbic acid antioxidant system in animals
Meister, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36891-6 · Cited by 812
Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases
Philip G. Board, Coggan, M., Chelvanayagam, G., Easteal, S., Jermiin, L. S., Schulte, G. K., Danley, D. E., Hoth, L. R., Griffor, M. C., Kamath, A. V., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001706200 · Cited by 736
The biochemical functions of ascorbic acid
Englard, S., & Seifter, S. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.002053 · Cited by 564
Nishikimi, M., Fukuyama, R., Minoshima, S., Shimizu, N., & Yagi, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36884-9 · Cited by 505
Research works printed but not linked: 1
- Moreau R, 1998, Fish acquired ascorbic acid synthesis prior to terrestrial vertebrate emergence, Free Radic Biol Med, 25, 989
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Items 101–200 of 792
Gan, R., Li, H., Gunaratne, A., Sui, Z., & Corke, H. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12257 · Cited by 90
Redox Control of Endoplasmic Reticulum Function
Csala, M., Margittai, É., & Bánhegyi, G. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2529 · Cited by 89
Placental accommodations for transport and metabolism during intra-uterine crowding in pigs
Vallet, J. L., McNeel, A. K., Miles, J. R., & Freking, B. A. (2014) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/2049-1891-5-55 · Cited by 86
Free Radicals and Antioxidants: Role of Enzymes and Nutrition
Kabel, A. M. (2014) · World Journal of Nutrition and Health · doi:10.12691/jnh-2-3-2 · Cited by 85
Marchitti, S. A., Chen, Y., Thompson, D. C., & Vasiliou, V. (2011) · Eye & Contact Lens Science & Clinical Practice · doi:10.1097/icl.0b013e3182212642 · Cited by 84
Wang, Y., Lilienfeldt, N., & Hekimi, S. (2024) · Physiological Reviews · doi:10.1152/physrev.00040.2023 · Cited by 88
Johnson, R. J., Gaucher, E. A., Sautin, Y. Y., Henderson, G. N., Angerhofer, A., & Benner, S. A. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.01.017 · Cited by 83
Ascorbate degradation in tomato leads to accumulation of oxalate, threonate and oxalyl threonate
Truffault, V., Fry, S. C., Stevens, R. G., & Gautier, H. (2016) · The Plant Journal · doi:10.1111/tpj.13439 · Cited by 82
Antioxidant Therapeutics in Parkinson’s Disease: Current Challenges and Opportunities
Duarte-Jurado, A. P., Gopar‐Cuevas, Y., Cárdenas, O. S., Loera‐Arias, M. D. J., Montes‐de‐Oca‐Luna, R., García‐García, A., & Rodríguez‐Rocha, H. (2021) · Antioxidants · doi:10.3390/antiox10030453 · Cited by 83
Regulation of gut microbiota by vitamin C, vitamin E and β-carotene
Li, X., Meng, L., Shen, L., & Ji, H. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112749 · Cited by 85
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Skibola, C. F., Bracci, P. M., Halperin, E., Nieters, A., Hubbard, A., Paynter, R. A., Skibola, D. R., Agana, L., Becker, N., Tressler, P., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002816 · Cited by 80
Li, Y., Xi, M., Guo, Y. C., Hai, C., Yang, W., & Qin, X.-J. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.10.029 · Cited by 82
Assessment of Cr(VI)-Induced Cytotoxicity and Genotoxicity Using High Content Analysis
Thompson, C. M., Federov, Y., Brown, D. D., Suh, M., Proctor, D. M., Kuriakose, L., Haws, L. C., & Harris, M. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042720 · Cited by 81
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Siegfried, C. J., & Shui, Y. (2019) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2019.02.008 · Cited by 77
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Egger, S., Chaikuad, A., Kavanagh, K. L., Oppermann, U. C. T., & Nidetzky, B. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381378 · Cited by 77
Akbari, A., Jelodar, G., Nazıfı, S., & Sajedianfard, J. (2016) · Zahedan Journal of Research in Medical Sciences · doi:10.17795/zjrms-4037 · Cited by 77
Zito, E. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4966 · Cited by 81
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Jiménez‐Gómez, A., Celador-Lera, L., Fradejas, M., Rivas, R., & 3 Associated I + D Unit, U.-C. (. (2017) · AIMS Microbiology · doi:10.3934/microbiol.2017.3.483 · Cited by 76
The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism
Cisternas, P., Silva-Álvarez, C., Martínez, F., Fernández, E., Ferrada, L., Oyarce, K., Salazar, K., Bolaños, J. P., & Nualart, F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12663 · Cited by 74
Engineering of primary carbon metabolism in filamentous fungi
Chroumpi, T., Mäkelä, M., & de Vries, R. P. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107551 · Cited by 73
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Aryal, B., Kwakye, J., Ariyo, O. W., Ghareeb, A. F. A., Milfort, M. C., Fuller, A. L., Khatiwada, S., Rekaya, R., & Aggrey, S. E. (2025) · Antioxidants · doi:10.3390/antiox14040471 · Cited by 85
Farjan, M., Dmitryjuk, M., Lipinski, Z., Łopieńska–Biernat, E., & Żółtowska, K. (2012) · Journal of Apicultural Research · doi:10.3896/ibra.1.51.3.07 · Cited by 73
Muñoz-Montesino, C., Roa, F. J., Peña, E., González, M., Sotomayor, K., Inostroza, E., Muñoz-Flores, C., González‐Chavarría, I., Maldonado, M., Solíz, C., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.021 · Cited by 72
Song, Y., Suntharalingam, K., Yeung, J. S., Royzen, M., & Lippard, S. J. (2013) · Bioconjugate Chemistry · doi:10.1021/bc400281a · Cited by 72
Cahill, L. E., Fontaine‐Bisson, B., & El‐Sohemy, A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28327 · Cited by 74
Walker, R. P., & Famiani, F. (2018) · Horticultural reviews · doi:10.1002/9781119431077.ch8 · Cited by 72
Douiev, L., Soiferman, D., Alban, C., & Saada, A. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm6010001 · Cited by 72
Ascorbate and plasma membrane electron transport—Enzymes vs efflux
Lane, D. J. R., & Lawen, A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.003 · Cited by 71
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Zhao, H. L., Tanaka, T., Halicka, H. D., Traganos, F., Zarębski, M., Dobrucki, J. W., & Darżynkiewicz, Z. (2007) · Cytometry Part A · doi:10.1002/cyto.a.20469 · Cited by 70
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Kim, H., Bae, S., Yu, Y., Kim, Y., Kim, H., Hwang, Y.-I., Kang, J. S., & Lee, W. J. (2012) · Immune Network · doi:10.4110/in.2012.12.1.18 · Cited by 72
Vitamin C and lifespan in model organisms
Pallauf, K., Bendall, J. K., Scheiermann, C., Watschinger, K., Hoffmann, J., Roeder, T., & Rimbach, G. H. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.04.046 · Cited by 69
Raymond, L. J., Deth, R. C., & Ralston, N. V. C. (2014) · Autism Research and Treatment · doi:10.1155/2014/164938 · Cited by 68
Application of antioxidants and centrifugation for cryopreservation of boar spermatozoa
Zhang, W., Yi, K., Chen, C., Hou, X., & Zhou, X. (2012) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2012.05.009 · Cited by 65
Widespread decay of vitamin-related pathways: coincidence or consequence?
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Siedliński, M., Postma, D. S., van Diemen, C. C., Blokstra, A., Smit, H. A., & Boezen, H. M. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200711-1749oc · Cited by 64
Vitamin C Deficiency Causes Muscle Atrophy and a Deterioration in Physical Performance
Takisawa, S., Funakoshi, T., Yatsu, T., Nagata, K., Aigaki, T., Machida, S., & Ishigami, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-41229-7 · Cited by 63
Fruit and Vegetable Antioxidants in Health
Blasa, M., Gennari, L., Angelino, D., & Ninfali, P. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374628-3.00003-7 · Cited by 63
The Role of Dehydroascorbate in Disulfide Bond Formation
Saaranen, M. J., Karala, A., Lappi, A., & Ruddock, L. W. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2674 · Cited by 63
Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism
Lane, D. J. R., Chikhani, S., Richardson, V., & Richardson, D. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.02.010 · Cited by 63
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Geserick, C., & Tenhaken, R. (2013) · The Plant Journal · doi:10.1111/tpj.12116 · Cited by 62
Li, H., Liu, Z.-W., Wu, Z.-J., Wang, Y.-X., Teng, R., & Zhuang, J. (2018) · Horticulture Research · doi:10.1038/s41438-018-0070-x · Cited by 62
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Nicks, M. E., O'Brien, M. M., & Bowler, R. P. (2011) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2011.579202 · Cited by 61
Williams, D. J., Edwards, D., Pun, S., Chaliha, M., Burren, B., Tinggi, U., & Sultanbawa, Y. (2016) · Food Research International · doi:10.1016/j.foodres.2016.08.004 · Cited by 60
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Marques, R., Maia, C. J., Vaz, C. V., Correia, S., & Socorro, S. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1323-3 · Cited by 61
Sato, Y., Uchiki, T., Iwama, M., Kishimoto, Y., Takahashi, R., & Ishigami, A. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.364 · Cited by 59
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Production of glucaric acid from myo-inositol in engineered Pichia pastoris
Liu, Y., Xu, G., Wang, C., Du, G., Chen, J., & Kang, Z. (2016) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2016.05.009 · Cited by 56
The Myo‐inositol pathway does not contribute to ascorbic acid synthesis
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On the physiological and cellular homeostasis of ascorbate
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García-Krauss, A., Ferrada, L., Astuya, A., Salazar, K., Cisternas, P., Martínez, F., Ramírez, E., & Nualart, F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9497-3 · Cited by 53
Pohanka, M., Pejchal, J., Snopková, S., Havlíčková, K., Karasová, J. Ž., Boštík, P., & Pikula, J. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712798868986 · Cited by 52
Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging
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Matteo, A. D., Simeone, G. D. R., Cirillo, A., Rao, M. A., & Vaio, C. D. (2020) · Scientia Horticulturae · doi:10.1016/j.scienta.2020.109741 · Cited by 52
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Chakraborti, S., & Bahnson, B. J. (2010) · Biochemistry · doi:10.1021/bi9022297 · Cited by 51
Bergquist, S. Å. M., Gertsson, U. E., Nordmark, L., & Olsson, M. E. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070396z · Cited by 50
Fujii, J., & Imai, H. (2014) · Spermatogenesis · doi:10.4161/21565562.2014.979108 · Cited by 50
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Telichowska, A., Kobus‐Cisowska, J., & Szulc, P. M. (2020) · Nutrients · doi:10.3390/nu12071966 · Cited by 48
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Metadata
- Authors
- Linster, C. L., & Van Schaftingen, E.
- Affiliations
- de Duve Institute (BE)
- ORCID
- Linster, Carole L.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2006-12-06
- Volume
- 274
- Issue
- 1
- Pages
- 1-22
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2065016714
- Cited by
- 757
- References
- 159
- Citations by year
- 2026: 20 · 2025: 42 · 2024: 66 · 2023: 46 · 2022: 49 · 2021: 61 · 2020: 65 · 2019: 36 · 2018: 26 · 2017: 31 · 2016: 34 · 2015: 31 · 2014: 38 · 2013: 44 · 2012: 37
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- green
- orbilu.uni.lu
- Licence
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- vitamin C, ascorbic acid biosynthesis, UDP-glucuronate, UDP-glucuronosyltransferase, aldehyde reductase, aldo-keto reductase superfamily, L-gulonolactone oxidase, SMP30, regucalcin, dehydroascorbic acid, glutathione, vitamin C degradation, scurvy
- MeSH terms
- Animals, Ascorbic Acid, Carbohydrate Dehydrogenases, Escherichia coli, Glucuronates, Humans, Hydrolysis, Mammals, Models, Biological, Pentose Phosphate Pathway, Uridine Diphosphate Glucuronic Acid, L-Gulonolactone Oxidase
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