Prevalence and Predictors of Sexual Problems, Relationship Stress, and Depression in Female Partners of Infertile Couples
Abstract
Introduction: Infertility has been associated with anxiety, stress, and sexual problems in both men and women. Aim: To assess quality of life, sexual health, and depression in the female partner of infertile couples. Methods: Couples presenting for the evaluation of infertility at two tertiary care medical centers were invited to participate in a survey study. Main Outcome Measures: Female partners completed the Female Sexual Function Index (FSFI) and a modified Self-Esteem and Relationship (SEAR) Questionnaire. Male partners completed the SEAR and the International Index of Erectile Function (IIEF). Both partners completed the Center for Epidemiological Studies Depression Scale (CES-D) for depression and the Short Form-36 (SF-36) for general quality of life. Demographic, fertility, and comorbidity information was recorded. Results: One hundred and twenty-one couples constitute the study population. Mean female and male age was 32 ± 5 and 35 ± 7 years, respectively. Most (92%) couples were married. Mean duration of relationship and marriage were 6.4 ± 3.9 and 3.8 ± 3.2 years, respectively. Mean duration of attempted conception was 24 ± 24 months. On CES-D, 19% of women had moderate and 13% had severe depression. Women reported significantly worse SF-36 Mental Health subscale scores (mean = 47.8, P < 0.05) compared with normative values. The mean total FSFI score was 28 ± 7 (maximum score of 36), with 26% of the women scoring below 26.55, an established cut-off for high risk of female sexual dysfunction. FSFI scores had a modest positive correlation with male IIEF scores (r = 0.37, P < 0.01), and there was a trend toward a negative correlation with female CES-D scores (r = −0.16, P < 0.06). These relationships were maintained on multivariate analysis. Conclusion: Depression and sexual dysfunction are prevalent in female partners of infertile couples. Female sexual function is positively correlated with male partner sexual function in this population.
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An estimated 30-40% of women attending infertility tertiary care facilities experience clinically significant depression and anxiety.
“An estimated 30%–40% of women attending infertility tertiary care facilities experience clinically significant depression and anxiety.”
From Infertility-related distress and clinical targets for psychotherapy: A qualitative study (2021) · cites this paper as [9]
High rate of clinical depression is seen among women struggling with infertility.
“This finding is consistent with the high rate of clinical depression seen among women struggling with infertility.7 9 10”
From Infertility-related distress and clinical targets for psychotherapy: A qualitative study (2021) · cites this paper as [9]
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- Authors
- Nelson, C. J., Shindel, A. W., Naughton, C. K., Ohebshalom, M., & Mulhall, J. P.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Corresponding author
- Nelson, Christian J.
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-01
- Volume
- 5
- Issue
- 8
- Pages
- 1907-1914
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W2006562088
- Cited by
- 194
- References
- 34
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 9 · 2021: 16 · 2020: 12 · 2019: 7 · 2018: 9 · 2017: 15 · 2016: 12 · 2015: 18 · 2014: 13 · 2013: 11 · 2012: 13
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Keywords
- infertility, female sexual dysfunction, depression, relationship stress, couples, female partners, quality of life, sexual health, male sexual function, erectile function
- MeSH terms
- Adult, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Erectile Dysfunction, Infertility, Male, Marriage, Quality of Life, Risk Factors, Stress, Psychological, Comorbidity, Sexual Dysfunctions, Psychological
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