The influence of the sympathetic impulse pattern on contractile responses of rat mesenteric arteries and veins
Abstract
Contractile responses to electrical field stimulation of excised small mesenteric arteries and veins of the rat were compared when stimuli were delivered in irregular bursts or at regular intervals. Spontaneously occurring skin vasoconstrictor impulses in a few‐unit median nerve recording in man were stored on tape and used to trigger a stimulator. Two irregular stimulation sequences at average frequencies of 1.6 and 1.8 Hz, respectively, were used. In the arteries, average contractile responses were significantly greater at an irregular than at an even stimulation frequency, but in the veins, similar degrees of contraction were obtained with the two modes of stimulation. The frequency‐response relationships to continuous regular stimulation showed the artery to respond less than the vein at low frequencies. This apparently explains the difference in behaviour between the vessels to irregular stimulation. The results show that not only the number of impulses, but also their pattern of occurrence, may influence the degree of vasoconstriction. Thus, the normal irregular sympathetic discharge pattern in itself has a bearing on the physiology of neuro‐effector control mechanisms.
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Frequent, irregular trains of sympathetic nerve firing lead to greatly heightened postsynaptic stimulation.
“Frequent, irregular trains of sympathetic nerve firing are documented to lead to greatly heightened postsynaptic stimulation.54,55”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [55]
Cites
Mulvany, M. J., & Halpern, W. (1977) · Circulation Research · doi:10.1161/01.res.41.1.19 · Cited by 2,157 · see citing works
Handbook of Physiology—The Cardiovascular System
Guyton, A. C. (1985) · Critical Care Medicine · doi:10.1097/00003246-198505000-00025 · Cited by 1,153 · see citing works
General Characteristics of Sympathetic Activity in Human Muscle Nerves
Delius, W., Hagbarth, K. ‐., Hongell, A., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05157.x · Cited by 831 · see citing works
Self-citationGeneral Characteristics of Sympathetic Activity in Human Skin Nerves
Hagbarth, K. E., Hallin, R. G., Hongell, A., Torebjörk, H. E., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05167.x · Cited by 689 · see citing works
Self-citationCONTROL OF RESISTANCE, EXCHANGE, AND CAPACITANCE FUNCTIONS IN THE PERIPHERAL CIRCULATION
Mellander, S., & Johansson, B. (1968) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07132-7 · Cited by 603 · see citing works
Discharges in mammalian sympathetic nerves
Adrian, E. D., Bronk, D. W., & Phillips, G. (1932) · The Journal of Physiology · doi:10.1113/jphysiol.1932.sp002832 · Cited by 448 · see citing works
Bini, G., Hagbarth, K. E., Hynninen, P., & Wallin, B. G. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013413 · Cited by 421 · see citing works
Self-citationMellander, S. (1960) · PubMed · Cited by 336 · see citing works
Folkow, B. (1952) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1952.tb00858.x · Cited by 233 · see citing works
Mulvany, M. J., & Nyborg, N. C. B. (1980) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1980.tb10977.x · Cited by 192 · see citing works
Effects of stimulation of the chorda tympani in bursts on submaxillary responses in the cat
Andersson, P., Bloom, S. R., Edwards, A. V., & Järhult, J. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014050 · Cited by 142 · see citing works
Mellander, S. (1960) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 138 · see citing works
Single Unit Sympathetic Activity in Human Skin Nerves during Rest and Various Manoeuvres
Hallin, R. G., & Torebjörk, H. E. (1974) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1974.tb05749.x · Cited by 134 · see citing works
Hirst, G. D. S., & Neild, T. O. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013269 · Cited by 114 · see citing works
Thorén, P., & Ricksten, S. (1979) · Clinical Science · doi:10.1042/cs057197s · Cited by 114 · see citing works
Discharge patterns of sympathetic neurons supplying skeletal muscle and skin in man and cat
Jänig, W., Sundlöf, G., & Wallin, B. G. (1983) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(83)90077-2 · Cited by 90 · see citing works
Self-citationAdrenergic transmissions in the guinea‐pig mesenteric artery and their cholinergic modulations.
Kuriyama, H., & Suzuki, H. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013831 · Cited by 82 · see citing works
Larsson, S. (1954) · Acta Physiologica Scandinavica · Cited by 78 · see citing works
Andersson, P., Bloom, S. R., & Järhult, J. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014495 · Cited by 59 · see citing works
Johansson, B., & Ljung, B. (1967) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1967.tb03630.x · Cited by 50 · see citing works
Self-citationAndersson, P. (1983) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1983.tb07281.x · Cited by 48 · see citing works
SOME CHARACTERISTICS OF THE ISOLATED SYMPATHETIC NERVE-PULMONARY ARTERY PREPARATION OF THE RABBIT
Bevan, J. A. (1962) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)26349-2 · Cited by 47 · see citing works
Different nerve responses in consecutive sections of the arterial system
Nilsson, H. (1984) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1984.tb07466.x · Cited by 41 · see citing works
Self-citationParotid responses to stimulation of the parasympathetic innervation in bursts in weaned lambs
Andersson, P., Bloom, S. R., & Edwards, A. V. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014335 · Cited by 31 · see citing works
Vasomotor Nerve Control of Isolated Arteries and Veins
Ljung, B., Bevan, J. A., Pegram, B. L., et al. (1975) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1975.tb05910.x · Cited by 30 · see citing works
Self-citationBloom, S. R., Edwards, A. V., & Ghatei, M. A. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015038 · Cited by 21 · see citing works
Patterns of single unit activity in sympathetic postganglionic nerves
Kollai, M., & Koizumi, K. (1980) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(80)90025-9 · Cited by 21 · see citing works
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Johns, E. J., Kopp, U. C., & DiBona, G. F. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100043 · Cited by 278 · see citing works
The discharge behaviour of single vasoconstrictor motoneurones in human muscle nerves
Macefield, V. G., Wallin, B. G., & Vallbo, A. B. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020482 · Cited by 248 · see citing works
Self-citationWallin, B. G., & Charkoudian, N. (2007) · Muscle & Nerve · doi:10.1002/mus.20831 · Cited by 206 · see citing works
Self-citationFairfax, S. T., Padilla, J., Vianna, L. C., Davis, M. J., & Fadel, P. J. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00842.2012 · Cited by 144 · see citing works
Kenney, M. J., Weiss, M. L., & Haywood, J. R. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01042.x · Cited by 121 · see citing works
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Lambert, E. A., Schlaich, M. P., Dawood, T., Sari, C., Chopra, R., Barton, D. A., Kaye, D. M., Elam, M., Esler, M. D., & Lambert, G. W. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.205351 · Cited by 68 · see citing works
Esler, M., Lambert, G., Schlaich, M., Dixon, J., Sari, C. I., & Lambert, E. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.09790 · Cited by 60 · see citing works
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Davis, M. J., Hill, M. A., & Kuo, L. (2008) · Microcirculation · doi:10.1016/b978-0-12-374530-9.00006-1 · Cited by 78 · see citing works
Lambert, E., Dawood, T., Schlaich, M., Straznicky, N., Esler, M., & Lambert, G. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04905.x · Cited by 44 · see citing works
Ando, S.-I., Imaizumi, T., & Takeshita, A. (1993) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(93)90054-x · Cited by 17 · see citing works
- Authors
- NILSSON, H., LJUNG, B., SjÖBLOM, N., & Wallin, B. G.
- Affiliations
- University of Gothenburg (SE)
- Uppsala University Hospital (SE)
- Corresponding author
- NILSSON, H.
- ORCID
- NILSSON, H.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1985-03
- Volume
- 123
- Issue
- 3
- Pages
- 303-309
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2092668132
- Cited by
- 114
- References
- 27
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- sympathetic activity, vasoconstriction, mesenteric arteries, mesenteric veins, electrical field stimulation, stimulation frequency, median nerve, vascular contractility
- MeSH terms
- Animals, Electric Stimulation, Male, Mesenteric Arteries, Mesenteric Veins, Synaptic Transmission, Rats, Inbred Strains, Sympathetic Nervous System, Vasoconstriction, Vasomotor System, Rats
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