SINGLE‐UNIT SYMPATHETIC DISCHARGE PATTERN IN PATHOLOGICAL CONDITIONS ASSOCIATED WITH ELEVATED CARDIOVASCULAR RISK
Abstract
SUMMARY: Although measuring the rate of firing of multi‐unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single‐unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervous system activity. Detailed firing patterns of sympathetic vasoconstrictor neurons have been recorded in conditions associated with sympathoexcitation such as heart failure, obstructive sleep apnoea syndrome, hypertension and obesity; conditions in which cardiovascular morbidity and mortality are demonstrably elevated. Moreover, in conditions such as anxiety disorders and depression, in which elevated cardiovascular risk has recently been established, single‐unit analysis has highlighted a disturbed sympathetic firing pattern, which could not be identified on multi‐unit MSNA recording. This disturbed sympathetic nerve firing pattern, characterized by increased incidence of multiple firing within a sympathetic burst, has deleterious consequences on the cardiovascular system. Single‐unit methodology may represent a major step forward in the understanding of the link between disturbed sympathetic nerve firing and associated cardiovascular risk.
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With the coexistence of impaired norepinephrine reuptake with firing salvos in normal-weight essential hypertension and in depressive illness and panic disorder, there is evidence of cardiac risk, even in panic disorder.
“Conversely, with the coexistence of impaired norepinephrine reuptake with firing salvos in normal-weight essential hypertension 31,[33][34][35][36] and in depressive illness 42,51,79 and panic disorder, 51,79,80 there is evidence of cardiac risk, 84 even in panic disorder.[85][86][87]”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [79]
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Self-citation
- Authors
- Lambert, E., Dawood, T., Schlaich, M., Straznicky, N., Esler, M., & Lambert, G.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Venue
- Clinical and Experimental Pharmacology and Physiology
- Publisher
- Wiley
- Published
- 2008-02-27
- Volume
- 35
- Issue
- 4
- Pages
- 503-507
- ISSN
- 0305-1870 (ISSN-L)
- 1440-1681
- OpenAlex
- W2111020812
- Cited by
- 44
- References
- 27
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- sympathoexcitation, cardiovascular risk, heart failure, obstructive sleep apnea, hypertension, obesity, anxiety disorders, depression
- MeSH terms
- Animals, Cardiovascular Diseases, Heart, Humans, Risk Factors, Sympathetic Nervous System
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