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Lactate kinetics in human tissues at rest and during exercise
Abstract
Lactate production in skeletal muscle has now been studied for nearly two centuries and still its production and functional role at rest and during exercise is much debated. In the early days skeletal muscle was mainly seen as the site of lactate production during contraction and lactate production associated with a lack of muscle oxygenation and fatigue. Later it was recognized that skeletal muscle not only played an important role in lactate production but also in lactate clearance and this led to a renewed interest, not the least from the Copenhagen School in the 1930s, in the metabolic role of lactate in skeletal muscle. With the introduction of lactate isotopes muscle lactate kinetics and oxidation could be studied and a simultaneous lactate uptake and release was observed, not only in muscle but also in other tissues. Therefore, this review will discuss in vivo human: (1) skeletal muscle lactate metabolism at rest and during exercise and suggestions are put forward to explain the simultaneous lactate uptake and release; and (2) lactate metabolism in the heart, liver, kidneys, brain, adipose tissue and lungs will be discussed and its potential importance in these tissues.
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“Most lactate disposal occurs via oxidation in working skeletal muscle during prolonged endurance exercise, but other tissues such as the brain, liver and kidneys are also involved in lactate turnover [121,122,123].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [122]
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Metadata
- Authors
- van Hall, G.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 199
- Issue
- 4
- Pages
- 499-508
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- OpenAlex
- W1502364020
- Cited by
- 346
- References
- 82
- Citations by year
- 2026: 13 · 2025: 30 · 2024: 29 · 2023: 26 · 2022: 27 · 2021: 37 · 2020: 31 · 2019: 28 · 2018: 24 · 2017: 21 · 2016: 18 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 14
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- lactate kinetics, physical activity, lactic acid production, lactate clearance, lactate oxidation, heart, liver, kidney, brain, adipose tissue, lung
- MeSH terms
- Adipose Tissue, Brain, Humans, Kidney, Liver, Muscle Contraction, Myocardium, Oxidation-Reduction, Rest, Tissue Distribution, Exercise, Muscle, Skeletal, Lactic Acid
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