Activity-dependent regulation of energy metabolism by astrocytes: an update

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · cited 2× · see citing works

Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.

Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056 · see citing works

Lactate metabolism: a new paradigm for the third millennium

Gladden, L. B. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058701 · Cited by 1,283 · see citing works

Metabolic coupling between glia and neurons

Tsacopoulos, M., & Magistretti, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00877.1996 · Cited by 1,006 · see citing works

The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511397200 · Cited by 894 · see citing works

Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis

Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742 · see citing works

Glycogen in astrocytes: possible function as lactate supply for neighboring cells

Dringen, R., Gebhardt, R., & Hamprecht, B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91429-v · Cited by 536 · see citing works

Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain

Bittar, P. G., Charnay, Y., Pellerin, L., Bouras, C., & Magistretti, P. J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199611000-00001 · Cited by 423 · see citing works

Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.

Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408 · see citing works

Biochemistry 5th ed

Berg, J. M., Tymoczko, J. L., & Stryer, L. (2002) · Cited by 380 · see citing works

Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by¹³C Nuclear Magnetic Resonance Spectroscopy: Elucidation of the Dominant Pathway for Neurotransmitter Glutamate Repletion and Measurement of Astrocytic Oxidative Metabolism

Lebon, V., Petersen, K. F., Cline, G. W., Shen, J., Mason, G. F., Dufour, S., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01523.2002 · Cited by 371 · see citing works

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.

Magistretti, P. J., Morrison, J. H., Shoemaker, W. J., Sapin, V., & Bloom, F. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6535 · Cited by 351 · see citing works

Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism

Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science · doi:10.1126/science.1112085 · Cited by 341 · see citing works

A Temporary Local Energy Pool Coupled to Neuronal Activity: Fluctuations of Extracellular Lactate Levels in Rat Brain Monitored with Rapid‐Response Enzyme‐Based Sensor

Hu, Y., & Wilson, G. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041484.x · Cited by 337 · see citing works

In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function

Rothman, D. L., Behar, K. L., Hyder, F., & Shulman, R. G. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142131 · Cited by 337 · see citing works

Glucose and lactate metabolism during brain activation

Dienel, G. A., & Hertz, L. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10079 · Cited by 329 · see citing works

Lactate is a Preferential Oxidative Energy Substrate over Glucose for Neurons in Culture

Bouzier-Sore, A.-K., Voisin, P., Canioni, P., Magistretti, P. J., & Pellerin, L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000091761.61714.25 · Cited by 328 · see citing works

A mathematical model of compartmentalized neurotransmitter metabolism in the human brain

Gruetter, R., Seaquist, E. R., & Ugurbil, K. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.1.e100 · Cited by 326 · see citing works

Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis

Chih, C.-P., & Roberts, E. L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000081369.51727.6f · Cited by 325 · see citing works

Lactate: The Ultimate Cerebral Oxidative Energy Substrate?

Schurr, A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600174 · Cited by 313 · see citing works

Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging

Shulman, R. G., Hyder, F., & Rothman, D. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101129298 · Cited by 299 · see citing works

Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia <i>in vitro</i> and on glucose utilization by brain <i>in vivo</i>

Itoh, Y., Esaki, T., Shimoji, K., Cook, M., Law, M. J., Kaufman, E., & Sokoloff, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831078100 · Cited by 297 · see citing works

Glial Glutamate Transporters Mediate a Functional Metabolic Crosstalk between Neurons and Astrocytes in the Mouse Developing Cortex

Voutsinos‐Porche, B., Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J., Magistretti, P. J., & Pellerin, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01170-4 · Cited by 293 · see citing works

Lactate: A Preferred Fuel for Human Brain Metabolism in Vivo

Smith, D., Pernet, A., Hallett, W. A., Bingham, E., Marsden, P. K., & Amiel, S. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000063991.19746.11 · Cited by 282 · see citing works

Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain

Pellerin, L., Halestrap, A. P., & Pierre, K. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20307 · Cited by 269 · see citing works

Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study

Bouzier‐Sore, A., Voisin, P., Bouchaud, V., Bezancon, E., Franconi, J., & Pellerin, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05056.x · Cited by 265 · see citing works

Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy.

Loaiza, A., Porras, O. H., & Barros, L. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07337.2003 · Cited by 254 · see citing works

Do active cerebral neurons really use lactate rather than glucose?

Chih, C.-P., Lipton, P., & Roberts, E. L. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01920-2 · Cited by 252 · cited 2× · see citing works

Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease

Kennedy, A. M., Frackowiak, R. S. J., Newman, S. K., Bloomfield, P. M., Seaward, J., Roques, P., Lewington, G., Cunningham, V. J., & Rossor, M. N. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11270-7 · Cited by 250 · see citing works

NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain

Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.61 · Cited by 249 · see citing works

Glycogen regulation and functional role in mouse white matter

Brown, A. M., Tekkök, S. B., & Ransom, B. R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042416 · Cited by 243 · see citing works

Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography

Swanson, R. A., Morton, M. M., Sagar, S. M., & Sharp, F. R. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90329-z · Cited by 237 · see citing works

Characterization of the glycogenolysis elicited by vasoactive intestinal peptide, noradrenaline and adenosine in primary cultures of mouse cerebral cortical astrocytes

Sorg, O., & Magistretti, P. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91538-c · Cited by 236 · see citing works

Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity

Tekkök, S. B., Brown, A. M., Westenbroek, R., Pellerin, L., & Ransom, B. R. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20573 · Cited by 224 · see citing works

Lactate as a pivotal element in neuron–glia metabolic cooperation

Pellerin, L. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00020-2 · Cited by 219 · see citing works

Glutamate Uptake Stimulates Na+,K+‐ATPase Activity in Astrocytes via Activation of a Distinct Subunit Highly Sensitive to Ouabain

Pellerin, L., & Magistretti, P. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052132.x · Cited by 210 · see citing works

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

Aubert, A., Costalat, R., Magistretti, P. J., & Pellerin, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505427102 · Cited by 207 · see citing works

Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells

Magistretti, P. J., Sorg, O., Yu, N., Martin, J.-L., & Pellerin, L. (1994) · Developmental Neuroscience · doi:10.1159/000111349 · Cited by 205 · cited 4× · see citing works

Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels

Ainscow, E., Mirshamsi, S., Tang, T., Ashford, M. L. J., & Rutter, G. A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022434 · Cited by 194 · see citing works

Glycolysis and Glutamate Accumulation into Synaptic Vesicles

Ikemoto, A., Bole, D. G., & Ueda, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211617200 · Cited by 193 · see citing works

Vasoactive intestinal peptide and noradrenaline exert long-term control on glycogen levels in astrocytes: blockade by protein synthesis inhibition

Sorg, O., & Magistretti, P. J. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04923.1992 · Cited by 193 · see citing works

Similar Perisynaptic Glial Localization for the Na+,K+-ATPase alpha2 Subunit and the Glutamate Transporters GLAST and GLT-1 in the Rat Somatosensory Cortex

Cholet, N. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.5.515 · Cited by 192 · see citing works

Energy transfer from astrocytes to axons: the role of CNS glycogen

Brown, A. M., Tekkök, S. B., & Ransom, B. R. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.11.005 · Cited by 186 · see citing works

Food for Thought: Challenging the Dogmas

Pellerin, L., & Magistretti, P. J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000096064.12129.3d · Cited by 186 · see citing works

Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia.

Takahashi, S., Driscoll, B. F., Law, M. J., & Sokoloff, L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4616 · Cited by 184 · see citing works

GABA uptake into astrocytes is not associated with significant metabolic cost: Implications for brain imaging of inhibitory transmission

Chatton, J., Pellerin, L., & Magistretti, P. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2132096100 · Cited by 180 · see citing works

A Model of the Coupling between Brain Electrical Activity, Metabolism, and Hemodynamics: Application to the Interpretation of Functional Neuroimaging

Aubert, A., & Costalat, R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1224 · Cited by 179 · see citing works

Metabolic network abnormalities in early Huntington's disease: an [(18)F]FDG PET study.

Feigin, A., Leenders, K. L., Moeller, J. R., Missimer, J. H., Kuenig, G., Spetsieris, P. G., Antonini, A., & Eidelberg, D. (2001) · PubMed · Cited by 178 · see citing works

Astrocytes generate Na + -mediated metabolic waves

Bernardinelli, Y., Magistretti, P. J., & Chatton, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405315101 · Cited by 178 · see citing works

Glucose is Necessary to Maintain Neurotransmitter Homeostasis during Synaptic Activity in Cultured Glutamatergic Neurons

Bak, L. K., Schousboe, A., Sonnewald, U., & Waagepetersen, H. S. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600281 · Cited by 170 · see citing works

Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter

Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, T. M., Schousboe, A., Waagepetersen, H. S., & Ransom, B. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20335 · Cited by 169 · see citing works

Oxidative and Nonoxidative Metabolism of Excited Neurons and Astrocytes

GJEDDE, A. H., Marrett, S., & Vafaee, M. S. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200201000-00001 · Cited by 168 · see citing works

Lactate transport and transporters: General principles and functional roles in brain cells

Hertz, L., & Dienel, G. A. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20294 · Cited by 167 · see citing works

Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought?

Dienel, G. A., & Cruz, N. F. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.10.011 · Cited by 160 · see citing works

A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with δ-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses

Bergersen, L., Wærhaug, O., Helm, J., Thomas, M., Laake, P., Davies, A. J., Wilson, M. C., Halestrap, A. P., & Ottersen, O. P. (2001) · Experimental Brain Research · doi:10.1007/s002210000600 · Cited by 155 · see citing works

The redox switch/redox coupling hypothesis

Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146 · see citing works

K+ at concentrations reached in the extracellular space during neuronal activity promotes a Ca2+-dependent glycogen hydrolysis in mouse cerebral cortex

Hof, P. R., Pascale, E., & Magistretti, P. J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01922.1988 · Cited by 145 · see citing works

Glutamate mediates acute glucose transport inhibition in hippocampal neurons

Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139 · see citing works

Interaction between Astrocytes and Neurons Studied using a Mathematical Model of Compartmentalized Energy Metabolism

Aubert, A., & Costalat, R. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600144 · Cited by 138 · see citing works

AMPA receptor modulators as cognitive enhancers

LYNCH, G. S. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.09.009 · Cited by 138 · see citing works

Adenosine stimulates glycogenolysis in mouse cerebral cortex: a possible coupling mechanism between neuronal activity and energy metabolism

Magistretti, P. J., Hof, P. R., & Martin, J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-09-02558.1986 · Cited by 131 · see citing works

The astrocyte-neuron lactate shuttle: a challenge of a challenge

Hertz, L. (2004) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1097/00004647-200411000-00008 · Cited by 124 · see citing works

Glycolysis in Neurons, Not Astrocytes, Delays Oxidative Metabolism of Human Visual Cortex during Sustained Checkerboard Stimulation in vivo

GJEDDE, A. H., & Marrett, S. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200112000-00002 · Cited by 112 · see citing works

Sensory-Evoked Intrinsic Optical Signals in the Olfactory Bulb Are Coupled to Glutamate Release and Uptake

Gurden, H., Uchida, N., & Mainen, Z. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.022 · Cited by 110 · see citing works

Selective Postsynaptic Co-localization of MCT2 with AMPA Receptor GluR2/3 Subunits at Excitatory Synapses Exhibiting AMPA Receptor Trafficking

Bergersen, L. H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh138 · Cited by 110 · see citing works

Cerebral Metabolism of Lactate in Vivo : Evidence for Neuronal Pyruvate Carboxylation

Hassel, B., & Bråthe, A. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200002000-00014 · Cited by 109 · see citing works

The aerobic brain: lactate decrease at the onset of neural activity

Mangia, S., Garreffa, G., Bianciardi, M., Giove, F., Salle, F. D., & Maraviglia, B. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00792-3 · Cited by 107 · see citing works

In vivo Identification and Quantitative Evaluation of Carrier-Mediated Transport of Lactate at the Cellular Level in the Striatum of Conscious, Freely Moving Rats

Kuhr, W. G., den Berg, C. J. V., & Korf, J. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.142 · Cited by 106 · see citing works

The Metabolism of [3‐13C]Lactate in the Rat Brain Is Specific of a Pyruvate Carboxylase‐Deprived Compartment

Bouzier‐Sore, A., Thiaudière, E., Biran, M., Rouland, R., Canioni, P., & Merle, M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750480.x · Cited by 105 · see citing works

Glutamate Increases Glycogen Content and Reduces Glucose Utilization in Primary Astrocyte Culture

Swanson, R. A., Yu, A. C. H., Chan, P. H., & Sharp, F. R. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01898.x · Cited by 102 · see citing works

Glyceraldehyde-3-Phosphate Dehydrogenase Is a GABAAReceptor Kinase Linking Glycolysis to Neuronal Inhibition

Laschet, J. J., Minier, F., Kurcewicz, I., Bureau, M., Trottier, S., Jeanneteau, F. D., Griffon, N., Samyn, B., BEEUMEN, J. V., Louvel, J., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0868-04.2004 · Cited by 100 · see citing works

Vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse cortical astrocytes: involvement in cAMP-regulated glycogen metabolism

Cardinaux, J., & Magistretti, P. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00919.1996 · Cited by 99 · see citing works

A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism

Aubert, A., Pellerin, L., Magistretti, P. J., & Costalat, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605864104 · Cited by 97 · see citing works

Regulation of glycogenolysis by neurotransmitters in the central nervous system.

Magistretti, P. J. (1988) · PubMed · Cited by 96 · see citing works

Local Injection of Antisense Oligonucleotides Targeted to the Glial Glutamate Transporter GLAST Decreases the Metabolic Response to Somatosensory Activation

Cholet, N., Pellerin, L., Welker, E., Lacombe, P. M., Seylaz, J., Magistretti, P. J., & Bonvento, G. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00009 · Cited by 90 · see citing works

Neighborly interactions of metabolically-activated astrocytes in vivo

Dienel, G. A., & Cruz, N. F. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00021-4 · Cited by 90 · see citing works

Stimulated release of lactate in freely moving rats is dependent on the uptake of glutamate.

Demestre, M., Boutelle, M. G., & Fillenz, M. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021971 · Cited by 86 · see citing works

Protein targeting to glycogen mRNA expression is stimulated by noradrenaline in mouse cortical astrocytes

Allaman, I., Pellerin, L., & Magistretti, P. J. (2000) · Glia · doi:10.1002/(sici)1098-1136(200006)30:4 · Cited by 86 · see citing works

Glucocorticoids modulate neurotransmitter‐induced glycogen metabolism in cultured cortical astrocytes

Allaman, I., Pellerin, L., & Magistretti, P. J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02235.x · Cited by 78 · see citing works

Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain

Laughton, J. D., Charnay, Y., Belloir, B., Pellerin, L., Magistretti, P. J., & Bouras, C. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00580-1 · Cited by 77 · see citing works

Oxidative Metabolism in Cultured Rat Astroglia: Effects of Reducing the Glucose Concentration in the Culture Medium and of D-Aspartate or Potassium Stimulation

Abe, T., Takahashi, S., & Suzuki, N. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600175 · Cited by 76 · see citing works

Effects of l-glutamate, d-aspartate, and monensin on glycolytic and oxidative glucose metabolism in mouse astrocyte cultures: further evidence that glutamate uptake is metabolically driven by oxidative metabolism

Peng, L., Swanson, R. A., & Hertz, L. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00104-2 · Cited by 74 · see citing works

Intracellular compartmentation of pyruvate in primary cultures of cortical neurons as detected by 13 C NMR spectroscopy with multiple 13 C labels

Cruz, F., Villalba, M., Garcia-Espinosa, M. A., Ballesteros, P., Bogónez, E., Satrústegui, J., & Cerdán, S. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10048 · Cited by 68 · see citing works

Cloning, localization and induction of mouse brain glycogen synthase

Pellegri, G., Rossier, C., Magistretti, P. J., & Martin, J. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00305-c · Cited by 66 · see citing works

Can Experimental Conditions Explain the Discrepancy over Glutamate Stimulation of Aerobic Glycolysis?

Hertz, L., Swanson, R. A., Newman, G. C., Marrif, H. I., Juurlink, B. H. J., & Peng, L. (1998) · Developmental Neuroscience · doi:10.1159/000017329 · Cited by 65 · see citing works

L‐Glutamate and Insulin Enhance Glycogen Synthesis in Cultured Astrocytes from the Rat Brain Through Different Intracellular Mechanisms

Hamai, M., Minokoshi, Y., & Shimazu, T. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730400.x · Cited by 63 · see citing works

Dual-Gene, Dual-Cell Type Therapy against an Excitotoxic Insult by Bolstering Neuroenergetics

Bliss, T. M., Ip, M., Cheng, E., Minami, M., Pellerin, L., Magistretti, P. J., & Sapolsky, R. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-04.2004 · Cited by 63 · see citing works

A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression

Allaman, I., Lengacher, S., Magistretti, P. J., & Pellerin, L. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00202.2002 · Cited by 60 · see citing works

Glial Glutamate Transporters and Maturation of the Mouse Somatosensory Cortex

Voutsinos‐Porche, B. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1110 · Cited by 57 · see citing works

13C-Labeled substrates and the cerebral metabolic compartmentalization of acetate and lactate

Tyson, R. L., Gallagher, C., & Sutherland, G. R. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.027 · Cited by 55 · see citing works

Neuroprotective gene therapy against acute neurological insults

Sapolsky, R. M. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1006 · Cited by 55 · see citing works

Determinants of brain activation-induced cortical NAD/NADH responses in vivo

́ra, E. ̈. D., Gyulai, L., & Kova´ch Arisztid, G. B. (1984) · Brain Research · doi:10.1016/0006-8993(84)90788-1 · Cited by 52 · see citing works

Ex Vivo Analysis of Lactate and Glucose Metabolism in the Rat Brain under Different States of Depressed Activity

Serres, S., Bezançon, E., Franconi, J., & Merle, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409429200 · Cited by 52 · see citing works

Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes

Brunet, J. F., Grollimund, L., Chatton, J., Lengacher, S., Magistretti, P. J., Villemure, J., & Pellerin, L. (2003) · Glia · doi:10.1002/glia.10348 · Cited by 52 · see citing works

Selective retinal pigment epithelial cell lipid metabolism and remodeling conserves photoreceptor docosahexaenoic acid following phagocytosis

Turco, E., Parkins, N., Ershov, A. V., & Bazan, N. G. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990815)57:4 · Cited by 51 · see citing works

Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α‐ketoglutarate dehydrogenase

Waagepetersen, H. S., Hansen, G. H., Fenger, K., LINDSAY, J. G., Gibson, G. E., & Schousboe, A. (2005) · Glia · doi:10.1002/glia.20276 · Cited by 50 · see citing works

Cultures of rat astrocytes challenged with a steady supply of glutamate: New model to study flux distribution in the glutamate–glutamine cycle

Fonseca, L. L., Monteiro, M. A. R., Alves, P. M., Carrondo, M. J. T., & Santos, H. (2005) · Glia · doi:10.1002/glia.20209 · Cited by 47 · see citing works

Lysophosphatidic Acid Decreases Glutamate and Glucose Uptake by Astrocytes

Keller, J. N., Steiner, M. R., Mattson, M. P., et al. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67062300.x · Cited by 46 · see citing works

Subcellular Topography and Plasticity of Gap Junction Distribution on Astrocytes

Rohlmann, A., & Wolff, J. R. (1996) · Neuroscience intelligence unit · doi:10.1007/978-3-662-21935-5_10 · Cited by 43 · see citing works

Ex vivo NMR study of lactate metabolism in rat brain under various depressed states

Serres, S., Bezançon, E., Franconi, J., & Merle, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20277 · Cited by 43 · see citing works

Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Sorg, O., Pellerin, L., Stolz, M., Beggah, S., & Magistretti, P. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11410-x · Cited by 42 · see citing works

Is Brain Lactate Metabolized Immediately after Neuronal Activity through the Oxidative Pathway?

Korf, J. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600321 · Cited by 36 · see citing works

Involvement of brain lactate in neuronal metabolism

Serres, S., Bouyer, J. J., Bezançon, E., Canioni, P., & Merle, M. (2003) · NMR in Biomedicine · doi:10.1002/nbm.838 · Cited by 34 · see citing works

Evidence for a Lactate Pool in the Rat Brain That is Not Used as an Energy Supply under Normoglycemic Conditions

Leegsma‐Vogt, G., Venema, K., & Korf, J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000080650.64357.8f · Cited by 30 · see citing works

Fuel use during glycogenesis in rainbow trout (Oncorhynchus mykissWalbaum) white muscle studiedin vitro

Kam, J. C., & Milligan, C. L. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02071 · Cited by 26 · see citing works

Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons

Morgenthaler, F. D., Kraftsik, R., Catsicas, S., Magistretti, P. J., & Chatton, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.065 · Cited by 26 · see citing works

Ampakine™ CX546 bolsters energetic response of astrocytes: a novel target for cognitive‐enhancing drugs acting as α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor modulators

Pellerin, L., & Magistretti, P. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02905.x · Cited by 26 · see citing works

Effectiveness of extracellular lactate/pyruvate for sustaining synaptic vesicle proton gradient generation and vesicular accumulation of GABA

Tarasenko, A. S., Linetska, M. V., Storchak, L. G., & Himmelreich, N. H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04109.x · Cited by 25 · see citing works

Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT‐1

Hérard, A., Dubois, A., Escartin, C., Tanaka, K., Delzescaux, T., Hantraye, P., & Bonvento, G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04346.x · Cited by 23 · see citing works

l-Glutamate decreases glucose utilization by rat cortical astrocytes

Liao, S., & Chen, C. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00721-3 · Cited by 22 · see citing works

The bipotential glial progenitor cell line can develop into both oligodendrocytes and astrocytes in the mouse forebrain

Sawamura, S., Sawada, M., Ito, M., Nagatsu, T., Nagatsu, I., Suzumura, A., Shibuya, M., Sugita, K., & Marunouchi, T. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11378-a · Cited by 21 · see citing works

[1- 13 C]Glucose Metabolism in Brain Cells: Isotopomer Analysis of Glutamine from Cerebellar Astrocytes and Glutamate from Granule Cells

Merle, M., Martin, M., Villégier, A., et al. (2007) · Developmental Neuroscience · doi:10.1159/000111441 · Cited by 20 · see citing works

A Star-Studded Search for Memory-Enhancing Drugs

Marshall, E. (2004) · Science · doi:10.1126/science.304.5667.36 · Cited by 18 · see citing works

Regulation by Neurotransmitters of Glial Energy Metabolism

Magistretti, P. J., & Pellerin, L. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-9551-6_10 · Cited by 16 · see citing works

Modeling Cerebral Arteriovenous Lactate Kinetics after Intravenous Lactate Infusion in the Rat

Leegsma‐Vogt, G., WERF, S. Y. V. D., Venema, K., & Korf, J. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000129417.80261.a6 · Cited by 16 · see citing works

Red and White Brain

Collins, R. C. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48635.x · Cited by 9 · see citing works

Glucose transporter proteins in brain: Delivery of glucose to neurons and glia

Vannucci, S. J., Maher, F., & Simpson, I. A. (1997) · Glia · doi:10.1002/(sici)1098-1136(199709)21:1

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285 · see citing works

Astrocyte reactivity and reactive astrogliosis: costs and benefits

Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1

Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844 · see citing works

Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals

Kim, S.-G., & Ogawa, S. (2012) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2012.23 · Cited by 547 · see citing works

The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

Liu, L., MacKenzie, K. R., Putluri, N., Maletić-Savatić, M., & Bellen, H. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.024 · Cited by 556 · see citing works

The bright side of being blue: depression as an adaptation for analyzing complex problems.

Andrews, P. W., & Thomson, J. A. (2009) · Psychological Review · doi:10.1037/a0016242 · Cited by 549 · see citing works

Cholesterol metabolism in neurons and astrocytes

Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works

Brain lactate metabolism: the discoveries and the controversies

Dienel, G. A. (2012) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2011.175 · Cited by 479 · see citing works

Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake

Díaz-García, C. M., Mongeon, R., Lahmann, C., Koveal, D., Zucker, H., & Yellen, G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.021 · Cited by 466 · see citing works

Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing

Hall, C. N., Klein-Flugge, M. C., Howarth, C., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-12.2012 · Cited by 451 · see citing works

The role of astroglia in neuroprotection

Bélanger, M., & Magistretti, P. J. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/mbelanger · Cited by 396 · see citing works

Lactate kinetics in human tissues at rest and during exercise

van Hall, G. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02122.x · Cited by 346 · see citing works

Glial glycolysis is essential for neuronal survival in Drosophila

Volkenhoff, A., Weiler, A., Letzel, M., Stehling, M., Klämbt, C., & Schirmeier, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.006 · Cited by 339 · see citing works

Gliotransmission: Beyond Black-and-White

Savtchouk, I., & Volterra, A. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0017-17.2017 · Cited by 325 · see citing works

Glia in mammalian development and disease

Zuchero, J. B., & Barres, B. A. (2015) · Development · doi:10.1242/dev.129304 · Cited by 304 · see citing works

Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response.

Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.018 · Cited by 281 · see citing works

Blood-brain barrier permeability and physical exercise

Małkiewicz, M. A., Szarmach, A., Sabisz, A., Cubała, W. J., Szurowska, E., & Winklewski, P. J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1403-x · Cited by 276 · see citing works

Cerebral Blood Flow Response to Functional Activation

Paulson, O. B., Hasselbalch, S. G., Rostrup, E., Knudsen, G. M., & Pelligrino, D. (2010) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2009.188 · Cited by 264 · see citing works

Bioenergetics and redox adaptations of astrocytes to neuronal activity

Bolaños, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13486 · Cited by 262 · see citing works

Antioxidant and bioenergetic coupling between neurons and astrocytes

Fernandez-Fernandez, S., Almeida, A., & Bolaños, J. P. (2012) · Biochemical Journal · doi:10.1042/bj20111943 · Cited by 247 · see citing works

Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex

Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0762-10.2010 · Cited by 217 · see citing works

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

Jimenez-Blasco, D., Santofimia-Castaño, P., Gonzalez, A., Almeida, A., & Bolaños, J. P. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2015.49 · Cited by 196 · see citing works

Lipid Metabolism Crosstalk in the Brain: Glia and Neurons

Barber, C. N., & Raben, D. M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00212 · Cited by 188 · see citing works

Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

Gandhi, G. K., Cruz, N. F., Ball, K. K., & Dienel, G. A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06333.x · Cited by 162 · see citing works

Metabolic and Hemodynamic Events after Changes in Neuronal Activity: Current Hypotheses, Theoretical Predictions and <i>in vivo</i> NMR Experimental Findings

Mangia, S., Giove, F., Tkáč, I., Logothetis, N. K., Henry, P.-G., Olman, C. A., Maraviglia, B., Di Salle, F., & Uğurbil, K. (2009) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2008.134 · Cited by 161 · see citing works

Central mechanisms of glucose sensing and counterregulation in defense of hypoglycemia

Stanley, S., Moheet, A., & Seaquist, E. R. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00226 · Cited by 112 · see citing works

Lactate as a biomarker for sleep

Naylor, E., Aillon, D. V., Barrett, B. S., Wilson, G. S., Johnson, D. A., Johnson, D. A., Harmon, H. P., Gabbert, S., & Petillo, P. A. (2012) · SLEEP · doi:10.5665/sleep.2072 · Cited by 112 · see citing works

Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse

Zhang, Y., Xue, Y., Meng, S., Luo, Y., Liang, J., Li, J., Ai, S., Sun, C., Shen, H., Zhu, W., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.007 · Cited by 106 · see citing works

Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes

Jovičić, A., & Gitler, A. D. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171418 · Cited by 86 · see citing works

Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes

Mamczur, P., Borsuk, B., Paszko, J., Sas, Z., Mozrzymas, J., Wiśniewski, J. R., Gizak, A., & Rakus, D. (2015) · Glia · doi:10.1002/glia.22753 · Cited by 71 · see citing works

Glial Cells and Integrity of the Nervous System

von Bernhardi, R., Eugenín-von Bernhardi, J., Flores, B., & Eugenín León, J. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-40764-7_1 · Cited by 67 · see citing works

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones

Arnold, S., de Araújo, G. W., & Beyer, C. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0085 · Cited by 65 · see citing works

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.020 · Cited by 65 · see citing works

Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients

Berndt, N., Kann, O., & Holzhütter, H.-G. (2015) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2015.70 · Cited by 56 · see citing works

Why does the brain (not) have glycogen?

DiNuzzo, M., Maraviglia, B., & Giove, F. (2011) · BioEssays · doi:10.1002/bies.201000151 · Cited by 53 · see citing works

Novel Model of Neuronal Bioenergetics: Postsynaptic Utilization of Glucose but not Lactate Correlates Positively with Ca ²⁺ Signalling in Cultured Mouse Glutamatergic Neurons

Bak, L. K., Obel, L. F., Walls, A. B., Schousboe, A., Faek, S. A. A., Jajo, F. S., & Waagepetersen, H. S. (2012) · ASN NEURO · doi:10.1042/an20120004 · Cited by 45 · see citing works

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

Mazuel, L., Blanc, J., Repond, C., Bouchaud, V., Raffard, G., Déglon, N., Bonvento, G., Pellerin, L., & Bouzier-Sore, A.-K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174990 · Cited by 44 · see citing works

MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease

Yoon, H., Flores, L. F., & Kim, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.020 · Cited by 23 · see citing works

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS

Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint

Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works

Anthoxanthum Mosaic Virus

Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works

Ecological and evolutionary importance of neighbors in the grass Anthoxanthum odoratum

Platenkamp, G. A. J., & Foin, T. C. (1990) · Oecologia · doi:10.1007/bf00317753 · Cited by 21 · see citing works