Cited by 346Cardiovascular and exercise physiologyMuscle metabolism and nutritionCancer, Hypoxia, and Metabolism

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Lactate kinetics in human tissues at rest and during exercise

van Hall, Gerrit·2010·Acta Physiologica

DOI 10.1111/j.1748-1716.2010.02122.x

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Abstract

Lactate production in skeletal muscle has now been studied for nearly two centuries and still its production and functional role at rest and during exercise is much debated. In the early days skeletal muscle was mainly seen as the site of lactate production during contraction and lactate production associated with a lack of muscle oxygenation and fatigue. Later it was recognized that skeletal muscle not only played an important role in lactate production but also in lactate clearance and this led to a renewed interest, not the least from the Copenhagen School in the 1930s, in the metabolic role of lactate in skeletal muscle. With the introduction of lactate isotopes muscle lactate kinetics and oxidation could be studied and a simultaneous lactate uptake and release was observed, not only in muscle but also in other tissues. Therefore, this review will discuss in vivo human: (1) skeletal muscle lactate metabolism at rest and during exercise and suggestions are put forward to explain the simultaneous lactate uptake and release; and (2) lactate metabolism in the heart, liver, kidneys, brain, adipose tissue and lungs will be discussed and its potential importance in these tissues.

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Authors: van Hall, G.
Venue: Acta Physiologica
Publisher: Wiley
Published: 2010-07
Volume: 199
Issue: 4
Pages: 499-508
ISSN: 1748-1708 (ISSN-L)
1748-1716
DOI: 10.1111/j.1748-1716.2010.02122.x
OpenAlex: W1502364020
Cited by: 346
References: 82
Citations by year: 2026: 13 · 2025: 30 · 2024: 29 · 2023: 26 · 2022: 27 · 2021: 37 · 2020: 31 · 2019: 28 · 2018: 24 · 2017: 21 · 2016: 18 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 14
FWCI: 2.49
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Physiologica (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: lactate kinetics, physical activity, lactic acid production, lactate clearance, lactate oxidation, heart, liver, kidney, brain, adipose tissue, lung
MeSH terms: Adipose Tissue, Brain, Humans, Kidney, Liver, Muscle Contraction, Myocardium, Oxidation-Reduction, Rest, Tissue Distribution, Exercise, Muscle, Skeletal, Lactic Acid

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Lactate kinetics in human tissues at rest and during exercise

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