Hormonal pertubations in fibromyalgia syndrome
Abstract
The symptomatology characterizing fibromyalgia (FM) comprises three systems: the musculoskeletal system with widespread muscular pain, neuroendocrine disorders, and psychological distress including depression. Though the most prominent symptom of FM is pain in defined points of the musculoskeletal system, the numerous other somatoform and psychological disorders suppose a common primary disturbance which we consider to originate within higher levels of the central nervous system. Recent studies of the entire endocrine profile of FM patients following a simultaneous challenge of the hypophysis with corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone, growth hormone-releasing hormone, and luteinizing hormone-releasing hormone support the hypothesis that an elevated activity of CRH neurons determines not only many symptoms of FM but may also cause the deviations observed in the other hormonal axes. Hypothalamic CRH neurons thus may play a key role not only in "resetting" the various endocrine loops but possibly also nociceptive and psychological mechanisms as well.
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Fibromyalgia patients show hypothalamus-pituitary-adrenocortical axis dysfunction.
“FM patients show hypothalamus–pituitary–adrenocortical axis (HPA) dysfunction [14,15].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [15]
The model is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis.
“Third, it is in tune with a bulk of data suggesting a role of HPA and HPG axes in FM pathogenesis [10–17]”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [15]
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- Authors
- NEECK, G., & RIEDEL, W.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Max Planck Society (DE)
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1999-06
- Volume
- 876
- Issue
- 1
- Pages
- 325-339
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2016270694
- Cited by
- 43
- References
- 69
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- fibromyalgia, corticotropin-releasing factor, neuroendocrine disorders, somatoform disorders, depression, growth hormone-releasing hormone, thyrotropin-releasing hormone, gonadotropin-releasing hormone, central sensitization, nociception
- MeSH terms
- Animals, Fibromyalgia, Hormones, Humans, Hypothalamo-Hypophyseal System, Pain, Pituitary-Adrenal System, Stress, Physiological
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