Cited by 43Fibromyalgia and Chronic Fatigue Syndrome ResearchStress Responses and CortisolPsychosomatic Disorders and Their Treatments

Hormonal pertubations in fibromyalgia syndrome

NEECK, GUNTHER, RIEDEL, WALTER·1999·Annals of the New York Academy of Sciences

Abstract

The symptomatology characterizing fibromyalgia (FM) comprises three systems: the musculoskeletal system with widespread muscular pain, neuroendocrine disorders, and psychological distress including depression. Though the most prominent symptom of FM is pain in defined points of the musculoskeletal system, the numerous other somatoform and psychological disorders suppose a common primary disturbance which we consider to originate within higher levels of the central nervous system. Recent studies of the entire endocrine profile of FM patients following a simultaneous challenge of the hypophysis with corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone, growth hormone-releasing hormone, and luteinizing hormone-releasing hormone support the hypothesis that an elevated activity of CRH neurons determines not only many symptoms of FM but may also cause the deviations observed in the other hormonal axes. Hypothalamic CRH neurons thus may play a key role not only in "resetting" the various endocrine loops but possibly also nociceptive and psychological mechanisms as well.

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Crossref · 10.1111/j.1749-6632.1999.tb07657.x

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69 of 69 references verified0 citation errors · 0 not checkable

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Authors
NEECK, G., & RIEDEL, W.
Affiliations
  • Justus-Liebig-Universität Gießen (DE)
  • Max Planck Society (DE)
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1999-06
Volume
876
Issue
1
Pages
325-339
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2016270694
Cited by
43
References
69
Citations by year
2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
0.43
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
fibromyalgia, corticotropin-releasing factor, neuroendocrine disorders, somatoform disorders, depression, growth hormone-releasing hormone, thyrotropin-releasing hormone, gonadotropin-releasing hormone, central sensitization, nociception
MeSH terms
Animals, Fibromyalgia, Hormones, Humans, Hypothalamo-Hypophyseal System, Pain, Pituitary-Adrenal System, Stress, Physiological

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