Impact of Fibromyalgia on Female Infertility
Open accessAbstract
Fibromyalgia is a chronic, widespread musculoskeletal pain and polyalgic syndrome, evolving for more than three months. Research on its consequences on fertility is therefore relevant to explore. The aim of this study is to highlight the relationship between fibromyalgia and some women’s diseases that induced infertility. The results showed that fibromyalgia is more common in 92.9% of patients wishing to procreate and 64.8% of patients with gynecological disorders. 70.7% of patients with menstrual disorder have fibromyalgia and 76.5% of fibromyalgia patients have myomas. Among ovarian pathologies, 76.5% of women with ovarian dystrophy have fibromyalgia. Fibromyalgia is also very prevalent in women with miscarriage (55.9%) and stillbirth history (90.1%). For all studied situations, a highly significant difference was observed (p < 0.000). All these data suggest that fibromyalgia is related to different situations that can induce infertility in women.
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Some of these conditions (menstrual disturbances, uterine disorders, ovarian dystrophy, ovarian cysts, miscarriage, and stillbirth) have been attributed, at least in some cases, to a depression of HPG functioning caused by excessive HPA activation.
“Some of these conditions, including menstrual disturbances, uterine disorders, ovarian dystrophy, ovarian cysts, miscarriage, and stillbirth, have been attributed, at least in some cases, to a depression of HPG functioning caused by excessive HPA activation [141].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [141]
The Introduction describes HPA hyperactivation in fibromyalgia and says CRH inhibits GnRH, a regulator of HPG function. The Discussion proposes hormonal explanations for menstrual disturbances, ovarian dystrophy and miscarriage. But it says the precise mechanism for ovarian cysts remains undetermined and discusses stillbirth through possible HPA and placental pathways without establishing HPG depression as the mechanism; it also does not clearly tie uterine disorders to that specific pathway. (LLM, conf=0.86)
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Cited by
Sorted by citations
Fibromyalgia pathogenesis explained by a neuroendocrine multistable model
Demori, I., Losacco, S., Giordano, G., Mucci, V., Blanchini, F., & Burlando, B. (2024) · PLOS ONE · doi:10.1371/journal.pone.0303573 · Cited by 14 · see citing works
Mahmoudi, F., & Haghighat, K. (2024) · Physiology and Pharmacology · doi:10.61186/phypha.28.1.10
- Authors
- Koné, M. C., Kambiré, N. A., & Ahoua, Y.
- Affiliations
- Université Félix Houphouët-Boigny (CI)
- Venue
- Open Journal of Epidemiology
- Publisher
- Scientific Research Publishing, Inc.
- Published
- 2021
- Volume
- 11
- Issue
- 04
- Pages
- 457-472
- ISSN
- 2165-7459 (ISSN-L)
- 2165-7467
- OpenAlex
- W3213842694
- Cited by
- 2
- References
- 45
- Citations by year
- 2024: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Open Journal of Epidemiology (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- fibromyalgia, female infertility, menstrual disorders, uterine fibroids, ovarian dysfunction, miscarriage, stillbirth, gynecological diseases, chronic widespread pain
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