Induction of CMV-1 promoter by 4-hydroxy-2-nonenal in human embryonic kidney cells.

Jaganjac, Morana; Matijevic, Tanja; Cindric, Marina; Cipak, Ana; Mrakovcic, Lidija; Gubisch, Wolfgang; Zarkovic, Neven

doi:10.18388/abp.2010_2392

Cited by 31Cytomegalovirus and herpesvirus researchRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Induction of CMV-1 promoter by 4-hydroxy-2-nonenal in human embryonic kidney cells.

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Jaganjac, Morana, Matijevic, Tanja, Cindric, Marina, Cipak, Ana, Mrakovcic, Lidija, Gubisch, Wolfgang, Zarkovic, Neven·2010·Acta Biochimica Polonica

DOI 10.18388/abp.2010_2392

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Abstract

Oxidative stress, i.e., excessive production of oxygen free radicals and reactive oxygen species, leads to lipid peroxidation and to formation of reactive aldehydes which act as second messengers of free radicals. It has previously been shown that oxidative stress may be involved in the transcriptional regulation of cytomegalovirus (CMV) immediate early promoter, involved in viral reactivation from latency. In the current study we used a plasmid containing the yellow fluorescent protein (YFP) gene under the control of CMV-1 promoter to monitor the influence of hydrogen peroxide and reactive aldehydes, 4-hydroxy-2-nonenal (HNE) and acrolein, on CMV-1 promoter activation in human embryonic kidney cells (HEK293). While acrolein was ineffective, hydrogen peroxide slightly (50 %) stimulated the CMV promoter. In contrast, HNE had a strong, up to 3-fold, enhancing effect on the CMV-1 promoter within four as well as after 24h of treatment. The most effective was the treatment with 24 microM HNE. This effect of HNE suggests that stressful conditions associated with lipid peroxidation could lead to CMV activation.

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Reactive oxygen species and 4-hydroxy-2-nonenal (HNE) can directly reactivate CMV, but this process can be inhibited by antioxidants.
“Mechanistic studies show that reactive oxygen species and one of the final products of lipid peroxidation, 4-hydroxy-2-nonenal (HNE), can directly reactivate CMV, but this process can be inhibited by antioxidants (Cinatl et al. 1999; Jaganjac et al. 2010; Speir 2000; Vossen et al. 1997).”
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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672 · see citing works
4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
Uchida, K. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00014-6 · Cited by 1,164 · see citing works
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
Kruman, I. I., Bruce‐Keller, A. J., Bredesen, D. E., Waeg, G., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05089.1997 · Cited by 719 · see citing works
Central nervous systems trauma and stroke
Braughler, J. M., & Hall, E. D. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90056-7 · Cited by 619 · see citing works
Central nervous system trauma and stroke
Hall, E. D., & Braughler, J. M. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90057-9 · Cited by 590 · see citing works
Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation
Uchida, K., Shiraishi, M., Naito, Y., Torii, Y., Nakamura, Y., & Osawa, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2234 · Cited by 569 · see citing works
4-Hydroxynonenal as a bioactive marker of pathophysiological processes
Žarković, N. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00023-2 · Cited by 398 · see citing works
Reactive oxygen species: Destroyers or messengers?
Bartosz, G. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.009 · Cited by 379 · see citing works
4-Hydroxynonenal and neurodegenerative diseases
Žarković, K. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00024-4 · Cited by 315 · see citing works
HNE interacts directly with JNK isoforms in human hepatic stellate cells.
Parola, M., Robino, G., Marra, F., Pinzani, M., Bellomo, G., Leonarduzzi, G., Chiarugi, P., Camandola, S., Poli, G., Waeg, G., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1413 · Cited by 297 · see citing works
Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases
Awasthi, S., Yang, Y., Tiwari, N. K., Patrick, B., Sharma, A., Li, J., & Awasthi, S. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.033 · Cited by 268 · see citing works
The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase
Hartley, D. P., Ruth, J. A., & Petersen, D. R. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1028 · Cited by 243 · see citing works
Involvement of Toll-like Receptor (TLR) 2 and TLR4 in Cell Activation by Mannuronic Acid Polymers
Flo, T. H., Ryan, L., Latz, E., Takeuchi, O., Monks, B. G., Lien, E., Halaas, Ø., Akira, S., Skjåk‐Bræk, G., Golenbock, D. T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201366200 · Cited by 196 · see citing works
Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress
Cheng, J.-Z., Sharma, R., Yang, Y., Singhal, S. S., Sharma, A., Saini, M. K., Singh, S. V., Zimniak, P., Awasthi, S., & Awasthi, Y. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106838200 · Cited by 185 · see citing works
4-Hydroxynonenal Prevents NF-κB Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent Proteolysis
Page, S., Fischer, C., Baumgartner, B., Haas, M., Kreusel, U., Loidl, G., Hayn, M., Ziegler‐Heitbrock, H. W. L., Neumeier, D., & Brand, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11611 · Cited by 166 · see citing works
Induction of Rat Aortic Smooth Muscle Cell Growth by the Lipid Peroxidation Product 4-Hydroxy-2-Nonenal
Ruef, J., Rao, G. N., Li, F., Bode, C., Patterson, C., Bhatnagar, A., & Runge, M. S. (1998) · Circulation · doi:10.1161/01.cir.97.11.1071 · Cited by 151 · see citing works
Signaling kinases modulated by 4-hydroxynonenal.
Leonarduzzi, G., Robbesyn, F., & Poli, G. (2004) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2004.08.027 · Cited by 143 · see citing works
Transfection of mGSTA4 in HL-60 Cells Protects against 4-Hydroxynonenal-Induced Apoptosis by Inhibiting JNK-Mediated Signaling
Cheng, J., Singhal, S. S., Sharma, A., Saini, M. K., Yang, Y., Awasthi, S., Zimniak, P., & Awasthi, S. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2452 · Cited by 121 · see citing works
Effects of mGST A4 Transfection on 4-Hydroxynonenal-Mediated Apoptosis and Differentiation of K562 Human Erythroleukemia Cells
Cheng, J.-Z., Singhal, S. S., Saini, M. K., Singhal, J., Piper, J. T., van Kuijk, F. J. G. M., Zimniak, P., Awasthi, S., & Awasthi, S. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1479 · Cited by 121 · see citing works
Selective Activation of the c-Jun N-Terminal Protein Kinase Pathway during 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells
Soh, Y., Jeong, K.-S., Lee, I. J., Bae, M., Kim, Y. C., & Song, B. J. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.3.535 · Cited by 115 · see citing works
Effects of 4-hydroxynonenal on adenylate cyclase and 5′-nucleotidase activities in rat liver plasma membranes
Paradisi, L., Panagini, C., Parola, M., Barrera, G., & Dianzani, M. U. (1985) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(85)80097-1 · Cited by 112 · see citing works
Stimulation of HeLa cell growth by physiological concentrations of 4‐hydroxynonenal
Žarković, N., Ilic, Z., Jurin, M., Schaur, R. J., Puhl, H., & Esterbauer, H. (1993) · Cell Biochemistry and Function · doi:10.1002/cbf.290110409 · Cited by 100 · see citing works
4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-κB signaling pathways
Lee, S. J., Seo, K. W., Yun, M. R., Bae, S. S., Lee, W. S., Hong, K. W., & Kim, C. D. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.022 · Cited by 91 · see citing works
4-Hydroxynonenal induces apoptosis, NF-κB-activation and formation of 8-isoprostane in vascular smooth nmuscle cells
Ruef, J., Moser, M., Bode, C., Kübler, W., & Runge, M. S. (2001) · Basic Research in Cardiology · doi:10.1007/s003950170064 · Cited by 87 · see citing works
4-Hydroxynonenal as a second messenger of free radicals and growth modifying factor
Žarković, N., Žarković, K., Schaur, R. J., Štolc, S., Schlag, G., Redl, H. R., Waeg, G., Borović, S., Lončarić, I., Jurić, G., et al. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00444-0 · Cited by 74 · see citing works
The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor κB in neurons
Camandola, S., Poli, G., & Mattson, M. P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00234-5 · Cited by 68 · see citing works
Enzyme-linked immunosorbent assay for 4-hydroxynonenal–histidine conjugates
Borović, S., Rabuzin, F., Waeg, G., & Žarković, N. (2006) · Free Radical Research · doi:10.1080/10715760600693422 · Cited by 63 · see citing works
Inhibition of cytomegalovirus immediate early gene expression: a therapeutic option?
Scholz, M., Doerr, H. W., & Cinatl, J. J. (2001) · Antiviral Research · doi:10.1016/s0166-3542(01)00126-7 · Cited by 63 · see citing works
Biogenic 4‐hydroxy‐2‐nonenal activates transcription factor AP‐1 but not NF‐κB in cells of the macrophage lineage
Camandola, S., Scavazza, A., Leonarduzzi, G., Biasi, F., Chiarpotto, E., Azzi, A., & Poli, G. (1997) · BioFactors · doi:10.1002/biof.5520060211 · Cited by 63 · see citing works
Cytomegalovirus Gene Regulation by Reactive Oxygen Species: Agents in Atherosclerosis
SPEIR, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06200.x · Cited by 56 · see citing works
4-Hydroxynonenal Modifies the Effects of Serum Growth Factors on the Expression of the c-fos Proto-Oncogene and the Proliferation of HeLa Carcinoma Cells
Kreuzer, T., Grube, R., Wutte, A., Žarković, N., & Schaur, R. J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00029-x · Cited by 56 · see citing works
4-Hydroxy-2,3-nonenal as a signal for cell function and differentiation.
Dianzani, U., Barrera, G., & Parola, M. (1999) · Acta Biochimica Polonica · doi:10.18388/abp.1999_4184 · Cited by 56 · see citing works
Differential regulation of cyclooxygenase‐2 and inducible nitric oxide synthase by 4‐hydroxynonenal in human osteoarthritic chondrocytes through ATF‐2/CREB‐1 transactivation and concomitant inhibition of NF‐κB signaling cascade
Vaillancourt, F., Morquette, B., Shi, Q., Fahmi, H., Lavigne, P., Battista, J. A. D., Fernandes, J., & Benderdour, M. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21110 · Cited by 55 · see citing works
The influence of 4‐hydroxy‐2‐nonenal on proliferation, differentiation and apoptosis of human osteosarcoma cells
Šunjić, S. B., Gašparović, A. Č., Rabuzin, F., Wildburger, R., & Žarković, N. (2005) · BioFactors · doi:10.1002/biof.5520240117 · Cited by 53 · see citing works
4-Hydroxy-2-nonenal Increases γ-Glutamylcysteine Synthetase Gene Expression in Alveolar Epithelial Cells
Liu, R.-M., Borok, Z., & Forman, H. J. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.4.4307 · Cited by 53 · see citing works
The carcinostatic and proapoptotic potential of 4-hydroxynonenal in HeLa cells is associated with its conjugation to cellular proteins.
Sovic, A., Borović, S., Lončarić, I., Kreuzer, T., Žarković, K., Vuković, T., Wäg, G., Hrašćan, R., Wintersteiger, R., Klinger, R. J., et al. (2001) · PubMed · Cited by 44 · see citing works
IMPACT OF OXIDATIVE STRESS ON HUMAN CYTOMEGALOVIRUS REPLICATION AND ON CYTOKINE-MEDIATED STIMULATION OF ENDOTHELIAL CELLS1
Scholz, M., Cínatl, J., Gross, V., Vogel, J.-U., Blaheta, R. A., Freisleben, H., Markus, B. H., & Doerr, H. W. (1996) · Transplantation · doi:10.1097/00007890-199606270-00017 · Cited by 39 · see citing works
4-Hydroxynonenal-Induced MEL Cell Differentiation Involves PKC Activity Translocation
Rinaldi, M., Barrera, G., Aquino, A., Spinsanti, P., Pizzimenti, S., Farace, M. G., Dianzani, M. U., & Fazio, V. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2691 · Cited by 34 · see citing works
Mutual dependence of growth modifying effects of 4-hydroxynonenal and fetal calf serum in vitro
Žarković, N., Schaur, R. J., Puhl, H., Jurin, M., & Esterbauer, H. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90208-9 · Cited by 33 · see citing works
Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization
Kim, Y. S., Park, Z., Kim, S. Y., Jeong, E., & Lee, J. Y. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.07.009 · Cited by 32 · see citing works
A new method for detection of HNE-histidine conjugates in rat inflammatory cells
Živković, M., Žarković, K., Škrinjar, L., Georg, W., Poljak‐Blaži, M., Šunjić, S. B., Schaur, R. J., & Žarković, N. (2005) · Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) · Cited by 28 · see citing works
Proinflammatory Potential of Cytomegalovirus Infection
Cinatl Jr., J., Vogel, J.-U., Kotchetkov, R., Scholz, M., & Doerr, H. W. (1999) · Intervirology · doi:10.1159/000053980 · Cited by 27 · see citing works
Inhibition of Melanoma B16-F10 Growth by Lipid Peroxidation Product 4-Hydroxynonenal
Žarković, N., Tillian, M., Schaur, J. R., Waeg, G., Jurin, M., & Esterbauer, H. (1995) · Cancer Biotherapy · doi:10.1089/cbr.1995.10.153 · Cited by 26 · see citing works
Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection
Gnana‐Prakasam, J. P., Zhang, M., Martin, P. M., Atherton, S. S., Smith, S. B., & Ganapathy, V. (2009) · Biochemical Journal · doi:10.1042/bj20082240 · Cited by 22 · see citing works
Role of NADPH Oxidase in Cytomegalovirus-Induced Proliferation of Human Coronary Artery Smooth Muscle Cells
Dhaunsi, G. S., Kaur, J., & Turner, R. B. (2003) · Journal of Biomedical Science · doi:10.1007/bf02256111 · Cited by 15 · see citing works
Latent infection and reactivation of human cytomegalovirus
Numazaki, K., Asanuma, H., & Chiba, S. (1995) · Serodiagnosis and Immunotherapy in Infectious Disease · doi:10.1016/0888-0786(95)95348-t · Cited by 13 · see citing works
Cyclic AMP regulate adenovirus mediated inducible nitric oxide synthase expression and CMV promoter activity in cultured hepatocytes
Zhang, B., Liu, Y., & Harbrecht, B. G. (2003) · Nitric Oxide · doi:10.1016/s1089-8603(03)00041-7 · Cited by 4 · see citing works
Chemotherapy increases transgene expression in leukemic cells
Vereecque, R., Saudemont, A., Depil, S., & Quesnel, B. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.413 · Cited by 2 · see citing works
Role of NADPH Oxidase in Cytomegalovirus-Induced Proliferation of Human Coronary Artery Smooth Muscle Cells
Dhaunsi, G. S., Kaur, J., & Turner, R. B. (2003) · Journal of Biomedical Science · doi:10.1159/000072377 · Cited by 2 · see citing works

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Research works printed but not linked: 1

Zollner H, Schaur RJ, Esterbauer H (1991) Biological activities of 4-hydroxyalkenals In: Oxidative stress: oxidants and antioxidants, H. Sies, ed, pp 319-336, Academic Press, London.

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Brunson, J. L., Khoretonenko, M. V., & Stokes, K. Y. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801078-5.00010-8 · Cited by 3 · see citing works
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IMPACT OF OXIDATIVE STRESS ON HUMAN CYTOMEGALOVIRUS REPLICATION AND ON CYTOKINE-MEDIATED STIMULATION OF ENDOTHELIAL CELLS1
Scholz, M., Cínatl, J., Gross, V., Vogel, J.-U., Blaheta, R. A., Freisleben, H., Markus, B. H., & Doerr, H. W. (1996) · Transplantation · doi:10.1097/00007890-199606270-00017 · Cited by 39 · see citing works
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Bruening, W., Giasson, B. I., Mushynski, W. E., & Durham, H. D. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.2.486 · Cited by 91 · see citing works
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Speir, E. H., Shibutani, T., Yu, Z., Ferrans, V. J., & Epstein, S. E. (1996) · Circulation Research · doi:10.1161/01.res.79.6.1143 · Cited by 118 · see citing works
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Sabberwal, P., Chapman, L., Clement, M., Fielding, C. A., Thomas, D., Stanton, R. J., & Humphreys, I. R. (2020) · Access Microbiology · doi:10.1099/acmi.ac2020.po0473
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Löser, P., Jennings, G. S., Strauss, M., & Sandig, V. (1998) · Journal of Virology · doi:10.1128/jvi.72.1.180-190.1998 · Cited by 277 · see citing works

Authors: Jaganjac, M., Matijevic, T., Cindric, M., Cipak, A., Mrakovcic, L., Gubisch, W., & Zarkovic, N.
Affiliations: Ruđer Bošković Institute (HR)
ORCID: Jaganjac, Morana
Venue: Acta Biochimica Polonica
Publisher: Frontiers Media SA
Published: 2010-05-31
Volume: 57
Issue: 2
Pages: 179-83
ISSN: 0001-527X (ISSN-L)
1734-154X
DOI: 10.18388/abp.2010_2392
OpenAlex: W2022703963
Cited by: 31
References: 48
Citations by year: 2025: 2 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 2
FWCI: 1.63
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-sa
Locations: Acta Biochimica Polonica (publishedVersion, cc-by-sa)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: cytomegalovirus, 4-hydroxynonenal, oxidative stress, lipid peroxidation, reactive aldehydes, hydrogen peroxide, acrolein, viral reactivation, transcriptional activation, HEK293 cells
MeSH terms: Aldehydes, Cell Line, Cell Survival, Cytomegalovirus, Humans, Kidney, Promoter Regions, Genetic, Virus Activation, Cysteine Proteinase Inhibitors

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Induction of CMV-1 promoter by 4-hydroxy-2-nonenal in human embryonic kidney cells.

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