Cited by 136Hemoglobinopathies and Related DisordersNitric Oxide and Endothelin EffectsHemoglobin structure and function

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Reactive Species in Sickle Cell Disease

ASLAN, MUTAY, THORNLEY‐BROWN, DENYSE, FREEMAN, BRUCE A.·2000·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2000.tb06201.x

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Abstract

A bstract: The red cell is a relatively abundant locus of both free radical generation and reaction. Erythrocytes have a high content of unsaturated membrane lipids, a rich oxygen supply and are densely packed with redox‐active hemoglobin residues. In response, red cells have a highly evolved and well‐integrated network of oxidant defense mechanisms that lend an ability to withstand oxidative stress. In the case of congenital hemoglobin mutations that underlie sickle cell disease, they become very susceptible to free radical‐mediated injury by virtue of enhanced endogenous rates of production of reactive species and impairment of tissue free radical defense mechanisms. In sickle cell disease, a combination of these susceptibility factors are hypothesized to lead to an overall impairment of vascular function, in large part due to loss of “bioactive” nitric oxide via the free radical‐mediated consumption of this vasoactive molecule.

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Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Self-citation
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Biology of disease: free radicals and tissue injury.
Freeman, B. Α., & Jd, C. (1982) · PubMed · Cited by 3,038
Self-citation
[44] Glutathione peroxidase
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,032
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia
Charache, S., Terrin, M. L., Moore, R. D., Dover, G. J., Barton, F. B., Eckert, S. V., McMahon, R. P., & Bonds, D. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322001 · Cited by 2,340
Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,201
Self-citation
Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease
Clarke, R., Daly, L., Robinson, K., Naughten, E. R., Cahalane, S. F., Fowler, B., & Graham, I. M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199104253241701 · Cited by 2,160

Show all 116 references

Research works printed but not linked: 11

Embury S.H. R.P. Hebbel N. Mohandas & M.H. Steinberg. 1996.InSickle Cell Disease. Philadelphia New York. Lippincott‐Raven.
Sadrzadeh S.M.H., 1984, Hemoglobin, J. Biol. Chem., 259, 14354
Chui D., 1979, Abnormal vitamin E and Glutathione peroxidase levels in sickle cell anemia, J. Clin. Med., 94, 542
Enwonwu C.O., 1989, Increased metabolic demand for arginine in sickle cell anaemia, Med. Sci. Res., 17, 997
10.1097/00000441-199012000-00005 · DOI
10.1016/S0002-9343(97)00129-0 · DOI
10.1056/NEJM196310242691701 · DOI
10.1016/S0002-9343(97)00129-0 · DOI
10.1111/j.1365-2796.1995.tb00884.x · DOI
10.1093/ajcn/40.2.235 · DOI
10.3109/10715769609149918 · DOI

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Authors: ASLAN, M., THORNLEY‐BROWN, D., & FREEMAN, B. A.
Affiliations: University of Alabama at Birmingham (US)
ORCID: ASLAN, MUTAY
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2000-01
Volume: 899
Issue: 1
Pages: 375-391
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2000.tb06201.x
OpenAlex: W2010943728
Cited by: 136
References: 116
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 5 · 2012: 7
FWCI: 0.54
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2216 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: sickle cell disease, reactive oxygen species, free radicals, erythrocytes, oxidative stress, hemoglobin, nitric oxide, vascular function
MeSH terms: Anemia, Sickle Cell, Humans, Reactive Oxygen Species

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Reactive Species in Sickle Cell Disease

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