Cited by 136Hemoglobinopathies and Related DisordersNitric Oxide and Endothelin EffectsHemoglobin structure and function

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Reactive Species in Sickle Cell Disease

ASLAN, MUTAY, THORNLEY‐BROWN, DENYSE, FREEMAN, BRUCE A.·2000·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2000.tb06201.x

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Abstract

A bstract: The red cell is a relatively abundant locus of both free radical generation and reaction. Erythrocytes have a high content of unsaturated membrane lipids, a rich oxygen supply and are densely packed with redox‐active hemoglobin residues. In response, red cells have a highly evolved and well‐integrated network of oxidant defense mechanisms that lend an ability to withstand oxidative stress. In the case of congenital hemoglobin mutations that underlie sickle cell disease, they become very susceptible to free radical‐mediated injury by virtue of enhanced endogenous rates of production of reactive species and impairment of tissue free radical defense mechanisms. In sickle cell disease, a combination of these susceptibility factors are hypothesized to lead to an overall impairment of vascular function, in large part due to loss of “bioactive” nitric oxide via the free radical‐mediated consumption of this vasoactive molecule.

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Authors: ASLAN, M., THORNLEY‐BROWN, D., & FREEMAN, B. A.
Affiliations: University of Alabama at Birmingham (US)
ORCID: ASLAN, MUTAY
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2000-01
Volume: 899
Issue: 1
Pages: 375-391
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2000.tb06201.x
OpenAlex: W2010943728
Cited by: 136
References: 116
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 5 · 2012: 7
FWCI: 0.54
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2216 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: sickle cell disease, reactive oxygen species, free radicals, erythrocytes, oxidative stress, hemoglobin, nitric oxide, vascular function
MeSH terms: Anemia, Sickle Cell, Humans, Reactive Oxygen Species

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Reactive Species in Sickle Cell Disease

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