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Cited by 507

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Fibrin and Wound Healing

CLARK, RICHARD A.F.·2001·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.2001.tb03522.x
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Abstract

Although hemostasis is the major role of fibrin in wound repair, once the clot is present the wound cells must deal with it. The invasion and clearing of fibrin by these cells involves multiple complex processes that may go array XXX and delay wound repair. A good example, of the latter is leg ulcers. These chronic wounds contain a plethora of proteases that digest fibronectin and growth factors in the fibrin clot resulting in a corrupt provisional matrix that no longer supports reepithelialization or granulation tissue formation. Every good wound care provider knows that these wounds will not heal unless the corrupt matrix is removed by vigorous debridement that stimulates the accumulation of a competent provisional matrix.

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Metadata

Authors
CLARK, R. A. F.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2001-06
Volume
936
Issue
1
Pages
355-367
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.2001.tb03522.x
OpenAlex
W2133602801
Cited by
507
References
4
FWCI
6.42
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1699 d)

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CLARK, R. A. F. (2001). Fibrin and Wound Healing. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2001.tb03522.x

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